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[Whole-body MRI in preoperative diagnostics of breast cancer--a comparison with [corrected] staging methods according to the S 3 guidelines].
Rofo. 2011 Dec; 183(12):1130-7.ROFO

Abstract

PURPOSE

The German Society of Senology (step-3 guidelines for the early recognition of breast cancer in Germany) recommends whole-body staging including chest X-ray, ultrasound of the liver and bone scintigraphy before systemic therapy in patients with breast cancer. The performance of these three examinations is time-consuming and involves radiation exposure. Whole-body MR imaging (WB-MRI) allows staging in a single examination without radiation exposure. The purpose of this study was to compare the diagnostic accuracy of WB-MRI with staging according to the guidelines.

MATERIALS AND METHODS

During 04/07 and 06/09, the initial staging in 51 patients (56 ± 12 yrs) with breast cancer (24 patients with lymph node metastases) was performed according to the S 3-guidelines. Additionally, all patients underwent contrast-enhanced WB-MRI (1.5-Tesla-Magnetom Avanto, Siemens, Erlangen). The findings of the different modalities were compared after correlation of the lesions by follow-up. The detection of suspicious findings and the accuracy of prediction of malignancy of the detected lesions were evaluated.

RESULTS

Overall, 14 metastases were detected in 4 of 51 patients after completion of the follow-up. By means of WB-MRI, all 14 metastases could be detected, while just 4 of these metastases were identified by the conventional methods.

CONCLUSION

The detection of distant metastases has an important impact on patient management. In this study WB-MRI in breast cancer staging has shown promising results in regard to possible clinical implementation as a matter of routine staging.

Authors+Show Affiliations

Institut für Klinische Radiologie und Nuklearmedizin, Universitätsmedizin Mannheim, Universität Heidelberg. daniel.hausmann@umm.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

22068844

Citation

Hausmann, D, et al. "[Whole-body MRI in Preoperative Diagnostics of Breast Cancer--a Comparison With [corrected] Staging Methods According to the S 3 Guidelines]." RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, vol. 183, no. 12, 2011, pp. 1130-7.
Hausmann D, Kern C, Schröder MT, et al. [Whole-body MRI in preoperative diagnostics of breast cancer--a comparison with [corrected] staging methods according to the S 3 guidelines]. Rofo. 2011;183(12):1130-7.
Hausmann, D., Kern, C., Schröder, M. T., Sütterlin, M., Schönberg, S. O., Neff, K. W., & Dinter, D. J. (2011). [Whole-body MRI in preoperative diagnostics of breast cancer--a comparison with [corrected] staging methods according to the S 3 guidelines]. RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, 183(12), 1130-7. https://doi.org/10.1055/s-0031-1281723
Hausmann D, et al. [Whole-body MRI in Preoperative Diagnostics of Breast Cancer--a Comparison With [corrected] Staging Methods According to the S 3 Guidelines]. Rofo. 2011;183(12):1130-7. PubMed PMID: 22068844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Whole-body MRI in preoperative diagnostics of breast cancer--a comparison with [corrected] staging methods according to the S 3 guidelines]. AU - Hausmann,D, AU - Kern,C, AU - Schröder,M T, AU - Sütterlin,M, AU - Schönberg,S O, AU - Neff,K W, AU - Dinter,D J, Y1 - 2011/11/08/ PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2012/2/2/medline SP - 1130 EP - 7 JF - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JO - Rofo VL - 183 IS - 12 N2 - PURPOSE: The German Society of Senology (step-3 guidelines for the early recognition of breast cancer in Germany) recommends whole-body staging including chest X-ray, ultrasound of the liver and bone scintigraphy before systemic therapy in patients with breast cancer. The performance of these three examinations is time-consuming and involves radiation exposure. Whole-body MR imaging (WB-MRI) allows staging in a single examination without radiation exposure. The purpose of this study was to compare the diagnostic accuracy of WB-MRI with staging according to the guidelines. MATERIALS AND METHODS: During 04/07 and 06/09, the initial staging in 51 patients (56 ± 12 yrs) with breast cancer (24 patients with lymph node metastases) was performed according to the S 3-guidelines. Additionally, all patients underwent contrast-enhanced WB-MRI (1.5-Tesla-Magnetom Avanto, Siemens, Erlangen). The findings of the different modalities were compared after correlation of the lesions by follow-up. The detection of suspicious findings and the accuracy of prediction of malignancy of the detected lesions were evaluated. RESULTS: Overall, 14 metastases were detected in 4 of 51 patients after completion of the follow-up. By means of WB-MRI, all 14 metastases could be detected, while just 4 of these metastases were identified by the conventional methods. CONCLUSION: The detection of distant metastases has an important impact on patient management. In this study WB-MRI in breast cancer staging has shown promising results in regard to possible clinical implementation as a matter of routine staging. SN - 1438-9010 UR - https://www.unboundmedicine.com/medline/citation/22068844/[Whole_body_MRI_in_preoperative_diagnostics_of_breast_cancer__a_comparison_with_[corrected]_staging_methods_according_to_the_S_3_guidelines]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1281723 DB - PRIME DP - Unbound Medicine ER -