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Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population.
Diabetes Metab Res Rev 2011; 27(8):867-71DM

Abstract

BACKGROUND

Recently, the association of a common STAT4 haplotype with type 1 diabetes (T1D) as well as rheumatoid arthritis has been documented in Caucasians and Koreans. STAT4 is involved in the signalling of interleukin-12 and γIFN, as well as interleukin-23. To discover genes affecting the susceptibility of common autoimmune diseases, we studied the association of polymorphisms in STAT4 with autoimmune thyroid disease (AITD) as well as T1D in the Korean population.

SUBJECTS AND METHODS

Four single-nucleotide polymorphisms on the chromosome 2q (rs11889341, rs7574865, rs8179673, and rs10181656), which were found to associate with rheumatoid arthritis were examined for association in a Korean sample of 428 AITD, 418 T1D patients, and 1060 controls.

RESULTS

The minor alleles of all four single-nucleotide polymorphisms and the reconstructed STAT4 haplotypes conferred significant degree of risk for AITD (p=10(-2) to 10(-4)). Although we found a weak association of rs11889341 with T1D (p<0.05), the same haplotypes were not associated with T1D susceptibility. When we stratified T1D patients according to the age of onset, the minor alleles of all four single-nucleotide polymorphisms and the same haplotypes showed significant association with the susceptibility of T1D in the early-onset subgroup (p<0.01), not in the late-onset subgroup.

CONCLUSION

STAT4 alleles and the same haplotypes might influence cytokine signalling, and therefore the development of AITD as well as T1D. These results reinforce the influence of STAT4 gene as a general autoimmune gene.

Authors+Show Affiliations

Department of Internal Medicine and Bioengineering, Hanyang University College of Medicine and Engineering, and Hanyang University Hospital, Seoul, Korea. parkys@hanyang.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22069275

Citation

Park, Yongsoo, et al. "Evidence for the Role of STAT4 as a General Autoimmunity Locus in the Korean Population." Diabetes/metabolism Research and Reviews, vol. 27, no. 8, 2011, pp. 867-71.
Park Y, Lee HS, Park Y, et al. Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population. Diabetes Metab Res Rev. 2011;27(8):867-71.
Park, Y., Lee, H. S., Park, Y., Min, D., Yang, S., Kim, D., & Cho, B. (2011). Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population. Diabetes/metabolism Research and Reviews, 27(8), pp. 867-71. doi:10.1002/dmrr.1263.
Park Y, et al. Evidence for the Role of STAT4 as a General Autoimmunity Locus in the Korean Population. Diabetes Metab Res Rev. 2011;27(8):867-71. PubMed PMID: 22069275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population. AU - Park,Yongsoo, AU - Lee,Hye-Soon, AU - Park,Youngjoo, AU - Min,Dongsoo, AU - Yang,Seiwon, AU - Kim,Dukhee, AU - Cho,Boyoun, PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2012/3/27/medline SP - 867 EP - 71 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab. Res. Rev. VL - 27 IS - 8 N2 - BACKGROUND: Recently, the association of a common STAT4 haplotype with type 1 diabetes (T1D) as well as rheumatoid arthritis has been documented in Caucasians and Koreans. STAT4 is involved in the signalling of interleukin-12 and γIFN, as well as interleukin-23. To discover genes affecting the susceptibility of common autoimmune diseases, we studied the association of polymorphisms in STAT4 with autoimmune thyroid disease (AITD) as well as T1D in the Korean population. SUBJECTS AND METHODS: Four single-nucleotide polymorphisms on the chromosome 2q (rs11889341, rs7574865, rs8179673, and rs10181656), which were found to associate with rheumatoid arthritis were examined for association in a Korean sample of 428 AITD, 418 T1D patients, and 1060 controls. RESULTS: The minor alleles of all four single-nucleotide polymorphisms and the reconstructed STAT4 haplotypes conferred significant degree of risk for AITD (p=10(-2) to 10(-4)). Although we found a weak association of rs11889341 with T1D (p<0.05), the same haplotypes were not associated with T1D susceptibility. When we stratified T1D patients according to the age of onset, the minor alleles of all four single-nucleotide polymorphisms and the same haplotypes showed significant association with the susceptibility of T1D in the early-onset subgroup (p<0.01), not in the late-onset subgroup. CONCLUSION: STAT4 alleles and the same haplotypes might influence cytokine signalling, and therefore the development of AITD as well as T1D. These results reinforce the influence of STAT4 gene as a general autoimmune gene. SN - 1520-7560 UR - https://www.unboundmedicine.com/medline/citation/22069275/Evidence_for_the_role_of_STAT4_as_a_general_autoimmunity_locus_in_the_Korean_population_ L2 - https://doi.org/10.1002/dmrr.1263 DB - PRIME DP - Unbound Medicine ER -