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Spider-venom peptides as therapeutics.
Toxins (Basel). 2010 12; 2(12):2851-71.T

Abstract

Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid subjugation of prey. Most spider venoms are dominated by disulfide-rich peptides that typically have high affinity and specificity for particular subtypes of ion channels and receptors. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides, making them a valuable resource for drug discovery. Here we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against a wide range of pathophysiological conditions including cardiovascular disorders, chronic pain, inflammation, and erectile dysfunction.

Authors+Show Affiliations

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4072, Australia. n.saez@imb.uq.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22069579

Citation

Saez, Natalie J., et al. "Spider-venom Peptides as Therapeutics." Toxins, vol. 2, no. 12, 2010, pp. 2851-71.
Saez NJ, Senff S, Jensen JE, et al. Spider-venom peptides as therapeutics. Toxins (Basel). 2010;2(12):2851-71.
Saez, N. J., Senff, S., Jensen, J. E., Er, S. Y., Herzig, V., Rash, L. D., & King, G. F. (2010). Spider-venom peptides as therapeutics. Toxins, 2(12), 2851-71. https://doi.org/10.3390/toxins2122851
Saez NJ, et al. Spider-venom Peptides as Therapeutics. Toxins (Basel). 2010;2(12):2851-71. PubMed PMID: 22069579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spider-venom peptides as therapeutics. AU - Saez,Natalie J, AU - Senff,Sebastian, AU - Jensen,Jonas E, AU - Er,Sing Yan, AU - Herzig,Volker, AU - Rash,Lachlan D, AU - King,Glenn F, Y1 - 2010/12/20/ PY - 2010/11/16/received PY - 2010/12/17/revised PY - 2010/12/17/accepted PY - 2011/11/10/entrez PY - 2011/11/10/pubmed PY - 2011/11/10/medline KW - cystine knot KW - drug discovery KW - drugs KW - peptide KW - spider venom KW - therapeutics SP - 2851 EP - 71 JF - Toxins JO - Toxins (Basel) VL - 2 IS - 12 N2 - Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid subjugation of prey. Most spider venoms are dominated by disulfide-rich peptides that typically have high affinity and specificity for particular subtypes of ion channels and receptors. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides, making them a valuable resource for drug discovery. Here we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against a wide range of pathophysiological conditions including cardiovascular disorders, chronic pain, inflammation, and erectile dysfunction. SN - 2072-6651 UR - https://www.unboundmedicine.com/medline/citation/22069579/Spider_venom_peptides_as_therapeutics_ L2 - http://www.mdpi.com/resolver?pii=toxins2122851 DB - PRIME DP - Unbound Medicine ER -