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Short-course antibiotics for prosthetic joint infections treated with prosthesis retention.
Clin Microbiol Infect 2012; 18(11):1143-8CM

Abstract

The purpose of the present study was to evaluate the significance of shortening the antibiotic treatment duration in prosthetic joint infections (PJI) treated with debridement, antibiotics and implant retention (DAIR). In April 2006 we shortened the total antibiotic treatment duration in total knee arthroplasty (TKA) PJIs from 6 months to 3 months and in total hip arthroplasty (THA) PJIs from 3 months to 2 months. All patients with TKA or THA PJI treated with DAIR between February 2001 and August 2009 were reviewed retrospectively. There were 132 patients treated with DAIR, of whom 86 (65%) completed the antibiotic therapy and were therefore eligible for comparison concerning the length of antibiotic treatment. There were 32 (37%) THA and 54 (63%) TKA PJIs in the comparison. The treatment succeeded in 34 (89.5%) patients treated with longer antibiotic treatment and in 42 (87.5%) of those treated with shorter antibiotic treatment (p 0.78). Our conclusion is that if the patient completes the antibiotic therapy, treatment duration of 3 months in TKA PJIs and 2 months in THA PJIs is as good as longer antibiotic treatment of 6 months or 3 months, respectively, in patients treated with DAIR.

Authors+Show Affiliations

Division of Orthopaedic and Trauma Surgery, Department of Operative Care, Oulu University Hospital, Oulu, Finland. ari-pekka.puhto@ppshp.fiNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22070556

Citation

Puhto, A-P, et al. "Short-course Antibiotics for Prosthetic Joint Infections Treated With Prosthesis Retention." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 18, no. 11, 2012, pp. 1143-8.
Puhto AP, Puhto T, Syrjala H. Short-course antibiotics for prosthetic joint infections treated with prosthesis retention. Clin Microbiol Infect. 2012;18(11):1143-8.
Puhto, A. P., Puhto, T., & Syrjala, H. (2012). Short-course antibiotics for prosthetic joint infections treated with prosthesis retention. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(11), pp. 1143-8. doi:10.1111/j.1469-0691.2011.03693.x.
Puhto AP, Puhto T, Syrjala H. Short-course Antibiotics for Prosthetic Joint Infections Treated With Prosthesis Retention. Clin Microbiol Infect. 2012;18(11):1143-8. PubMed PMID: 22070556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-course antibiotics for prosthetic joint infections treated with prosthesis retention. AU - Puhto,A-P, AU - Puhto,T, AU - Syrjala,H, Y1 - 2011/11/09/ PY - 2011/11/11/entrez PY - 2011/11/11/pubmed PY - 2013/3/2/medline SP - 1143 EP - 8 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin. Microbiol. Infect. VL - 18 IS - 11 N2 - The purpose of the present study was to evaluate the significance of shortening the antibiotic treatment duration in prosthetic joint infections (PJI) treated with debridement, antibiotics and implant retention (DAIR). In April 2006 we shortened the total antibiotic treatment duration in total knee arthroplasty (TKA) PJIs from 6 months to 3 months and in total hip arthroplasty (THA) PJIs from 3 months to 2 months. All patients with TKA or THA PJI treated with DAIR between February 2001 and August 2009 were reviewed retrospectively. There were 132 patients treated with DAIR, of whom 86 (65%) completed the antibiotic therapy and were therefore eligible for comparison concerning the length of antibiotic treatment. There were 32 (37%) THA and 54 (63%) TKA PJIs in the comparison. The treatment succeeded in 34 (89.5%) patients treated with longer antibiotic treatment and in 42 (87.5%) of those treated with shorter antibiotic treatment (p 0.78). Our conclusion is that if the patient completes the antibiotic therapy, treatment duration of 3 months in TKA PJIs and 2 months in THA PJIs is as good as longer antibiotic treatment of 6 months or 3 months, respectively, in patients treated with DAIR. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/22070556/Short_course_antibiotics_for_prosthetic_joint_infections_treated_with_prosthesis_retention_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)60752-7 DB - PRIME DP - Unbound Medicine ER -