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Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients.
Prostaglandins Leukot Essent Fatty Acids. 2012 Jan-Feb; 86(1-2):29-34.PL

Abstract

Erythrocyte membrane fatty acids (FA), such as oleic acid, are related to acute coronary syndrome. There is no report about the effect of omega-3 FA on oleic acid in peritoneal dialysis (PD) patients. We hypothesized that omega-3 FA can modify erythrocyte membrane FA, including oleic acid, in PD patients. In a double-blind, randomized, placebo-controlled study, 18 patients who were treated with PD for at least 6 months were randomized to treatment for 12 weeks with omega-3 FA or placebo. Erythrocyte membrane FA content was measured by gas chromatography at baseline and after 12 weeks. The erythrocyte membrane content of eicosapentaenoic acid and docosahexaenoic acid was significantly increased and saturated FA and oleic acid were significantly decreased in the omega-3 FA supplementation group after 12 weeks compared to baseline. In conclusion, erythrocyte membrane FA content, including oleic acid, was significantly modified by omega-3 FA supplementation for 12 weeks in PD patients.

Authors+Show Affiliations

Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea. anws@dau.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22071008

Citation

An, W S., et al. "Effect of Omega-3 Fatty Acids On the Modification of Erythrocyte Membrane Fatty Acid Content Including Oleic Acid in Peritoneal Dialysis Patients." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 86, no. 1-2, 2012, pp. 29-34.
An WS, Lee SM, Son YK, et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. Prostaglandins Leukot Essent Fatty Acids. 2012;86(1-2):29-34.
An, W. S., Lee, S. M., Son, Y. K., Kim, S. E., Kim, K. H., Han, J. Y., Bae, H. R., & Park, Y. (2012). Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 86(1-2), 29-34. https://doi.org/10.1016/j.plefa.2011.10.009
An WS, et al. Effect of Omega-3 Fatty Acids On the Modification of Erythrocyte Membrane Fatty Acid Content Including Oleic Acid in Peritoneal Dialysis Patients. Prostaglandins Leukot Essent Fatty Acids. 2012 Jan-Feb;86(1-2):29-34. PubMed PMID: 22071008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. AU - An,W S, AU - Lee,S M, AU - Son,Y K, AU - Kim,S E, AU - Kim,K H, AU - Han,J Y, AU - Bae,H R, AU - Park,Y, Y1 - 2011/11/08/ PY - 2011/06/19/received PY - 2011/10/21/revised PY - 2011/10/22/accepted PY - 2011/11/11/entrez PY - 2011/11/11/pubmed PY - 2012/5/19/medline SP - 29 EP - 34 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 86 IS - 1-2 N2 - Erythrocyte membrane fatty acids (FA), such as oleic acid, are related to acute coronary syndrome. There is no report about the effect of omega-3 FA on oleic acid in peritoneal dialysis (PD) patients. We hypothesized that omega-3 FA can modify erythrocyte membrane FA, including oleic acid, in PD patients. In a double-blind, randomized, placebo-controlled study, 18 patients who were treated with PD for at least 6 months were randomized to treatment for 12 weeks with omega-3 FA or placebo. Erythrocyte membrane FA content was measured by gas chromatography at baseline and after 12 weeks. The erythrocyte membrane content of eicosapentaenoic acid and docosahexaenoic acid was significantly increased and saturated FA and oleic acid were significantly decreased in the omega-3 FA supplementation group after 12 weeks compared to baseline. In conclusion, erythrocyte membrane FA content, including oleic acid, was significantly modified by omega-3 FA supplementation for 12 weeks in PD patients. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/22071008/Effect_of_omega_3_fatty_acids_on_the_modification_of_erythrocyte_membrane_fatty_acid_content_including_oleic_acid_in_peritoneal_dialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(11)00183-9 DB - PRIME DP - Unbound Medicine ER -