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Mediterranean-style diet and risk of ischemic stroke, myocardial infarction, and vascular death: the Northern Manhattan Study.
Am J Clin Nutr 2011; 94(6):1458-64AJ

Abstract

BACKGROUND

A dietary pattern common in regions near the Mediterranean appears to reduce risk of all-cause mortality and ischemic heart disease. Data on blacks and Hispanics in the United States are lacking, and to our knowledge only one study has examined a Mediterranean-style diet (MeDi) in relation to stroke.

OBJECTIVE

In this study, we examined an MeDi in relation to vascular events.

DESIGN

The Northern Manhattan Study is a population-based cohort to determine stroke incidence and risk factors (mean ± SD age of participants: 69 ± 10 y; 64% women; 55% Hispanic, 21% white, and 24% black). Diet was assessed at baseline by using a food-frequency questionnaire in 2568 participants. A higher score on a 0-9 scale represented increased adherence to an MeDi. The relation between the MeDi score and risk of ischemic stroke, myocardial infarction (MI), and vascular death was assessed with Cox models, with control for sociodemographic and vascular risk factors.

RESULTS

The MeDi-score distribution was as follows: 0-2 (14%), 3 (17%), 4 (22%), 5 (22%), and 6-9 (25%). Over a mean follow-up of 9 y, 518 vascular events accrued (171 ischemic strokes, 133 MIs, and 314 vascular deaths). The MeDi score was inversely associated with risk of the composite outcome of ischemic stroke, MI, or vascular death (P-trend = 0.04) and with vascular death specifically (P-trend = 0.02). Moderate and high MeDi scores were marginally associated with decreased risk of MI. There was no association with ischemic stroke.

CONCLUSIONS

Higher consumption of an MeDi was associated with decreased risk of vascular events. Results support the role of a diet rich in fruit, vegetables, whole grains, fish, and olive oil in the promotion of ideal cardiovascular health.

Authors+Show Affiliations

Evelyn F McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, FL 33136, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22071704

Citation

Gardener, Hannah, et al. "Mediterranean-style Diet and Risk of Ischemic Stroke, Myocardial Infarction, and Vascular Death: the Northern Manhattan Study." The American Journal of Clinical Nutrition, vol. 94, no. 6, 2011, pp. 1458-64.
Gardener H, Wright CB, Gu Y, et al. Mediterranean-style diet and risk of ischemic stroke, myocardial infarction, and vascular death: the Northern Manhattan Study. Am J Clin Nutr. 2011;94(6):1458-64.
Gardener, H., Wright, C. B., Gu, Y., Demmer, R. T., Boden-Albala, B., Elkind, M. S., ... Scarmeas, N. (2011). Mediterranean-style diet and risk of ischemic stroke, myocardial infarction, and vascular death: the Northern Manhattan Study. The American Journal of Clinical Nutrition, 94(6), pp. 1458-64. doi:10.3945/ajcn.111.012799.
Gardener H, et al. Mediterranean-style Diet and Risk of Ischemic Stroke, Myocardial Infarction, and Vascular Death: the Northern Manhattan Study. Am J Clin Nutr. 2011;94(6):1458-64. PubMed PMID: 22071704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean-style diet and risk of ischemic stroke, myocardial infarction, and vascular death: the Northern Manhattan Study. AU - Gardener,Hannah, AU - Wright,Clinton B, AU - Gu,Yian, AU - Demmer,Ryan T, AU - Boden-Albala,Bernadette, AU - Elkind,Mitchell S V, AU - Sacco,Ralph L, AU - Scarmeas,Nikolaos, Y1 - 2011/11/09/ PY - 2011/11/11/entrez PY - 2011/11/11/pubmed PY - 2012/2/4/medline SP - 1458 EP - 64 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 6 N2 - BACKGROUND: A dietary pattern common in regions near the Mediterranean appears to reduce risk of all-cause mortality and ischemic heart disease. Data on blacks and Hispanics in the United States are lacking, and to our knowledge only one study has examined a Mediterranean-style diet (MeDi) in relation to stroke. OBJECTIVE: In this study, we examined an MeDi in relation to vascular events. DESIGN: The Northern Manhattan Study is a population-based cohort to determine stroke incidence and risk factors (mean ± SD age of participants: 69 ± 10 y; 64% women; 55% Hispanic, 21% white, and 24% black). Diet was assessed at baseline by using a food-frequency questionnaire in 2568 participants. A higher score on a 0-9 scale represented increased adherence to an MeDi. The relation between the MeDi score and risk of ischemic stroke, myocardial infarction (MI), and vascular death was assessed with Cox models, with control for sociodemographic and vascular risk factors. RESULTS: The MeDi-score distribution was as follows: 0-2 (14%), 3 (17%), 4 (22%), 5 (22%), and 6-9 (25%). Over a mean follow-up of 9 y, 518 vascular events accrued (171 ischemic strokes, 133 MIs, and 314 vascular deaths). The MeDi score was inversely associated with risk of the composite outcome of ischemic stroke, MI, or vascular death (P-trend = 0.04) and with vascular death specifically (P-trend = 0.02). Moderate and high MeDi scores were marginally associated with decreased risk of MI. There was no association with ischemic stroke. CONCLUSIONS: Higher consumption of an MeDi was associated with decreased risk of vascular events. Results support the role of a diet rich in fruit, vegetables, whole grains, fish, and olive oil in the promotion of ideal cardiovascular health. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22071704/Mediterranean_style_diet_and_risk_of_ischemic_stroke_myocardial_infarction_and_vascular_death:_the_Northern_Manhattan_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.012799 DB - PRIME DP - Unbound Medicine ER -