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Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata.

Abstract

BACKGROUND

US black women have higher rates of uterine leiomyomata (UL) and lower intakes of fruit and vegetables than do white women. Whether fruit and vegetable intake is associated with UL in black women has not been studied.

OBJECTIVE

We assessed the association of dietary intake of fruit, vegetables, carotenoids, folate, fiber, and vitamins A, C, and E with UL in the Black Women's Health Study.

DESIGN

In this prospective cohort study, we followed 22,583 premenopausal women for incident UL (1997-2009). Diet was estimated by using food-frequency questionnaires in 1995 and 2001. Cox regression was used to derive incidence rate ratios (IRRs) and 95% CIs for the association between each dietary variable (in quintiles) and UL.

RESULTS

There were 6627 incident cases of UL diagnosed by ultrasonography (n = 4346) or surgery (n = 2281). Fruit and vegetable intake was inversely associated with UL (≥4 compared with <1 serving/d; IRR: 0.90; 95% CI: 0.82, 0.98; P-trend = 0.03). The association was stronger for fruit (≥2 servings/d compared with <2 servings/wk; IRR: 0.89; 95% CI: 0.81, 0.98; P-trend = 0.07) than for vegetables (≥2 servings/d compared with <4 servings/wk: IRR: 0.97; 95% CI: 0.89, 1.05; P-trend = 0.51). Citrus fruit intake was inversely associated with UL (≥3 servings/wk compared with <1 serving/mo: IRR: 0.92; 95% CI: 0.86, 1.00; P-trend = 0.01). The inverse association for dietary vitamin A (upper compared with lower quintiles: IRR: 0.89; 95% CI: 0.83, 0.97; P-trend = 0.01) appeared to be driven by preformed vitamin A (animal sources), not provitamin A (fruit and vegetable sources). UL was not materially associated with dietary intake of vitamins C and E, folate, fiber, or any of the carotenoids, including lycopene.

CONCLUSION

These data suggest a reduced risk of UL among women with a greater dietary intake of fruit and preformed vitamin A.

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  • Authors+Show Affiliations

    ,

    Slone Epidemiology Center at Boston University, MA 02215, USA. lwise@bu.edu

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    Source

    MeSH

    Adult
    Carotenoids
    Citrus
    Diet
    Diet Surveys
    Female
    Fruit
    Humans
    Incidence
    Leiomyomatosis
    Phytotherapy
    Premenopause
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    United States
    Uterine Neoplasms
    Uterus
    Vegetables
    Vitamin A
    Vitamins

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22071705

    Citation

    Wise, Lauren A., et al. "Intake of Fruit, Vegetables, and Carotenoids in Relation to Risk of Uterine Leiomyomata." The American Journal of Clinical Nutrition, vol. 94, no. 6, 2011, pp. 1620-31.
    Wise LA, Radin RG, Palmer JR, et al. Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata. Am J Clin Nutr. 2011;94(6):1620-31.
    Wise, L. A., Radin, R. G., Palmer, J. R., Kumanyika, S. K., Boggs, D. A., & Rosenberg, L. (2011). Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata. The American Journal of Clinical Nutrition, 94(6), pp. 1620-31. doi:10.3945/ajcn.111.016600.
    Wise LA, et al. Intake of Fruit, Vegetables, and Carotenoids in Relation to Risk of Uterine Leiomyomata. Am J Clin Nutr. 2011;94(6):1620-31. PubMed PMID: 22071705.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata. AU - Wise,Lauren A, AU - Radin,Rose G, AU - Palmer,Julie R, AU - Kumanyika,Shiriki K, AU - Boggs,Deborah A, AU - Rosenberg,Lynn, Y1 - 2011/11/09/ PY - 2011/11/11/entrez PY - 2011/11/11/pubmed PY - 2012/2/4/medline SP - 1620 EP - 31 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 6 N2 - BACKGROUND: US black women have higher rates of uterine leiomyomata (UL) and lower intakes of fruit and vegetables than do white women. Whether fruit and vegetable intake is associated with UL in black women has not been studied. OBJECTIVE: We assessed the association of dietary intake of fruit, vegetables, carotenoids, folate, fiber, and vitamins A, C, and E with UL in the Black Women's Health Study. DESIGN: In this prospective cohort study, we followed 22,583 premenopausal women for incident UL (1997-2009). Diet was estimated by using food-frequency questionnaires in 1995 and 2001. Cox regression was used to derive incidence rate ratios (IRRs) and 95% CIs for the association between each dietary variable (in quintiles) and UL. RESULTS: There were 6627 incident cases of UL diagnosed by ultrasonography (n = 4346) or surgery (n = 2281). Fruit and vegetable intake was inversely associated with UL (≥4 compared with <1 serving/d; IRR: 0.90; 95% CI: 0.82, 0.98; P-trend = 0.03). The association was stronger for fruit (≥2 servings/d compared with <2 servings/wk; IRR: 0.89; 95% CI: 0.81, 0.98; P-trend = 0.07) than for vegetables (≥2 servings/d compared with <4 servings/wk: IRR: 0.97; 95% CI: 0.89, 1.05; P-trend = 0.51). Citrus fruit intake was inversely associated with UL (≥3 servings/wk compared with <1 serving/mo: IRR: 0.92; 95% CI: 0.86, 1.00; P-trend = 0.01). The inverse association for dietary vitamin A (upper compared with lower quintiles: IRR: 0.89; 95% CI: 0.83, 0.97; P-trend = 0.01) appeared to be driven by preformed vitamin A (animal sources), not provitamin A (fruit and vegetable sources). UL was not materially associated with dietary intake of vitamins C and E, folate, fiber, or any of the carotenoids, including lycopene. CONCLUSION: These data suggest a reduced risk of UL among women with a greater dietary intake of fruit and preformed vitamin A. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22071705/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.016600 DB - PRIME DP - Unbound Medicine ER -