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Height loss in older women: risk of hip fracture and mortality independent of vertebral fractures.
J Bone Miner Res. 2012 Jan; 27(1):153-9.JB

Abstract

We examined if height loss in older women predicts risk of hip fractures, other nonspine fractures, and mortality, and whether this risk is independent of both vertebral fractures (VFx) and bone mineral density (BMD) by dual-energy X-ray absorptiometry. Among 3124 women age 65 and older in the Study of Osteoporotic Fractures, we assessed the association with measured height change between year 0 (1986-1988) and year 15 (2002-2004) and subsequent risk of radiologically confirmed hip fractures, other nonspine fractures, and mortality assessed via death certificates. Follow-up occurred every 4 months for fractures and vital status (>95% contacts complete). Cox proportional hazards models assessed risk of hip fracture, nonspine fracture, and mortality over a mean of 5 years after height change was assessed (ie, after final height measurement). After adjustment for VFx, BMD, and other potential covariates, height loss >5 cm was associated with a marked increased risk of hip fracture [hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.06, 2.12], nonspine fracture (HR 1.48; 95% CI 1.20, 1.83), and mortality (1.45; 95% CI 1.21, 1.73). Although primary analyses were a subset of 3124 survivors healthy enough to return for a year 15 height measurement, a sensitivity analysis in the entire cohort (n = 9677) using initial height in earlier adulthood [self-reported height at age 25 (-40 years) to measured height age >65 years (Year 0)] demonstrated consistent results. Height loss >5 cm (2″) in older women was associated with a nearly 50% increased risk of hip fracture, nonspine fracture, and mortality-independent of incident VFx and BMD.

Authors+Show Affiliations

Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, USA. Teresa.Hillier@kpchr.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22072593

Citation

Hillier, Teresa A., et al. "Height Loss in Older Women: Risk of Hip Fracture and Mortality Independent of Vertebral Fractures." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 27, no. 1, 2012, pp. 153-9.
Hillier TA, Lui LY, Kado DM, et al. Height loss in older women: risk of hip fracture and mortality independent of vertebral fractures. J Bone Miner Res. 2012;27(1):153-9.
Hillier, T. A., Lui, L. Y., Kado, D. M., LeBlanc, E. S., Vesco, K. K., Bauer, D. C., Cauley, J. A., Ensrud, K. E., Black, D. M., Hochberg, M. C., & Cummings, S. R. (2012). Height loss in older women: risk of hip fracture and mortality independent of vertebral fractures. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 27(1), 153-9. https://doi.org/10.1002/jbmr.558
Hillier TA, et al. Height Loss in Older Women: Risk of Hip Fracture and Mortality Independent of Vertebral Fractures. J Bone Miner Res. 2012;27(1):153-9. PubMed PMID: 22072593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Height loss in older women: risk of hip fracture and mortality independent of vertebral fractures. AU - Hillier,Teresa A, AU - Lui,Li-Yung, AU - Kado,Deborah M, AU - LeBlanc,E S, AU - Vesco,Kimberly K, AU - Bauer,Douglas C, AU - Cauley,Jane A, AU - Ensrud,Kristine E, AU - Black,Dennis M, AU - Hochberg,Marc C, AU - Cummings,Steven R, PY - 2011/03/08/received PY - 2011/09/06/revised PY - 2011/09/26/accepted PY - 2011/11/11/entrez PY - 2011/11/11/pubmed PY - 2013/7/5/medline SP - 153 EP - 9 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 27 IS - 1 N2 - We examined if height loss in older women predicts risk of hip fractures, other nonspine fractures, and mortality, and whether this risk is independent of both vertebral fractures (VFx) and bone mineral density (BMD) by dual-energy X-ray absorptiometry. Among 3124 women age 65 and older in the Study of Osteoporotic Fractures, we assessed the association with measured height change between year 0 (1986-1988) and year 15 (2002-2004) and subsequent risk of radiologically confirmed hip fractures, other nonspine fractures, and mortality assessed via death certificates. Follow-up occurred every 4 months for fractures and vital status (>95% contacts complete). Cox proportional hazards models assessed risk of hip fracture, nonspine fracture, and mortality over a mean of 5 years after height change was assessed (ie, after final height measurement). After adjustment for VFx, BMD, and other potential covariates, height loss >5 cm was associated with a marked increased risk of hip fracture [hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.06, 2.12], nonspine fracture (HR 1.48; 95% CI 1.20, 1.83), and mortality (1.45; 95% CI 1.21, 1.73). Although primary analyses were a subset of 3124 survivors healthy enough to return for a year 15 height measurement, a sensitivity analysis in the entire cohort (n = 9677) using initial height in earlier adulthood [self-reported height at age 25 (-40 years) to measured height age >65 years (Year 0)] demonstrated consistent results. Height loss >5 cm (2″) in older women was associated with a nearly 50% increased risk of hip fracture, nonspine fracture, and mortality-independent of incident VFx and BMD. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/22072593/Height_loss_in_older_women:_risk_of_hip_fracture_and_mortality_independent_of_vertebral_fractures_ L2 - https://doi.org/10.1002/jbmr.558 DB - PRIME DP - Unbound Medicine ER -