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Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.
Int J Mol Sci 2011; 12(10):6529-43IJ

Abstract

Licorice has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. In this study, we evaluated the antihepatotoxic effect of licorice aqueous extract (LE) on the carbon tetrachloride (CCl(4))-induced liver injury in a rat model. Hepatic damage, as reveled by histology and the increased activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, and decreased levels of serum total protein (TP), albumin (Alb) and globulin (G) were induced in rats by an administration of CCl(4) at 3 mL/kg b.w. (1:1 in groundnut oil). Licorice extract significantly inhibited the elevated AST, ALP and ALT activities and the decreased TP, Alb and G levels caused by CCl(4) intoxication. It also enhanced liver super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), Glutathione S-transferase (GST) activities and glutathione (GSH) level, reduced malondialdehyde (MDA) level. Licorice extract still markedly reverses the increased liver hydroxyproline and serum TNF-α levels induced by CCl(4) intoxication. The data of this study support a chemopreventive potential of licorice extract against liver oxidative injury.

Authors+Show Affiliations

Department of General Surgery, Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China; E-Mails: hzhhuodr7@sina.com (H.Z.H.); bwang5032@sina.com (B.W.); ykliangshyy1@sina.com (Y.K.L.); yybaodr28@sina.com (Y.Y.B.).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22072903

Citation

Huo, Hai Zhong, et al. "Hepatoprotective and Antioxidant Effects of Licorice Extract Against CCl₄-induced Oxidative Damage in Rats." International Journal of Molecular Sciences, vol. 12, no. 10, 2011, pp. 6529-43.
Huo HZ, Wang B, Liang YK, et al. Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats. Int J Mol Sci. 2011;12(10):6529-43.
Huo, H. Z., Wang, B., Liang, Y. K., Bao, Y. Y., & Gu, Y. (2011). Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats. International Journal of Molecular Sciences, 12(10), pp. 6529-43. doi:10.3390/ijms12106529.
Huo HZ, et al. Hepatoprotective and Antioxidant Effects of Licorice Extract Against CCl₄-induced Oxidative Damage in Rats. Int J Mol Sci. 2011;12(10):6529-43. PubMed PMID: 22072903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats. AU - Huo,Hai Zhong, AU - Wang,Bing, AU - Liang,Yong Kang, AU - Bao,Yong Yang, AU - Gu,Yan, Y1 - 2011/10/06/ PY - 2011/07/28/received PY - 2011/09/04/revised PY - 2011/09/26/accepted PY - 2011/11/11/entrez PY - 2011/11/11/pubmed PY - 2011/11/11/medline KW - AST KW - CCl4 KW - antioxidant KW - licorice KW - liver KW - rat SP - 6529 EP - 43 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 12 IS - 10 N2 - Licorice has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. In this study, we evaluated the antihepatotoxic effect of licorice aqueous extract (LE) on the carbon tetrachloride (CCl(4))-induced liver injury in a rat model. Hepatic damage, as reveled by histology and the increased activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, and decreased levels of serum total protein (TP), albumin (Alb) and globulin (G) were induced in rats by an administration of CCl(4) at 3 mL/kg b.w. (1:1 in groundnut oil). Licorice extract significantly inhibited the elevated AST, ALP and ALT activities and the decreased TP, Alb and G levels caused by CCl(4) intoxication. It also enhanced liver super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), Glutathione S-transferase (GST) activities and glutathione (GSH) level, reduced malondialdehyde (MDA) level. Licorice extract still markedly reverses the increased liver hydroxyproline and serum TNF-α levels induced by CCl(4) intoxication. The data of this study support a chemopreventive potential of licorice extract against liver oxidative injury. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/22072903/Hepatoprotective_and_antioxidant_effects_of_licorice_extract_against_CCl₄_induced_oxidative_damage_in_rats_ L2 - http://www.mdpi.com/resolver?pii=ijms-12-06529 DB - PRIME DP - Unbound Medicine ER -