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An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis.
PLoS One. 2011; 6(10):e27130.Plos

Abstract

Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI:2.37-4.15), and for those with affected father 2.35 times (CI:2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI:2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR:2.87, CI:2.21-3.74), than in men aged 65 and older (RR:1.92, CI:1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI:55.6-63.5%) for men at all ages, 65.2% (CI:57.7-71.4%) for men younger than 65 and 47.9% (CI:37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI:65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).

Authors+Show Affiliations

Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium. michal.kicinski@uhasselt.beNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22073129

Citation

Kiciński, Michał, et al. "An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: a Meta-analysis." PloS One, vol. 6, no. 10, 2011, pp. e27130.
Kiciński M, Vangronsveld J, Nawrot TS. An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. PLoS ONE. 2011;6(10):e27130.
Kiciński, M., Vangronsveld, J., & Nawrot, T. S. (2011). An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. PloS One, 6(10), e27130. https://doi.org/10.1371/journal.pone.0027130
Kiciński M, Vangronsveld J, Nawrot TS. An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: a Meta-analysis. PLoS ONE. 2011;6(10):e27130. PubMed PMID: 22073129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. AU - Kiciński,Michał, AU - Vangronsveld,Jaco, AU - Nawrot,Tim S, Y1 - 2011/10/31/ PY - 2011/01/16/received PY - 2011/10/11/accepted PY - 2011/11/11/entrez PY - 2011/11/11/pubmed PY - 2012/3/2/medline SP - e27130 EP - e27130 JF - PloS one JO - PLoS ONE VL - 6 IS - 10 N2 - Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25-2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI:2.37-4.15), and for those with affected father 2.35 times (CI:2.02-2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI:2.61-7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR:2.87, CI:2.21-3.74), than in men aged 65 and older (RR:1.92, CI:1.49-2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI:55.6-63.5%) for men at all ages, 65.2% (CI:57.7-71.4%) for men younger than 65 and 47.9% (CI:37.1-56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI:65.4-85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65). SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22073129/An_epidemiological_reappraisal_of_the_familial_aggregation_of_prostate_cancer:_a_meta_analysis_ L2 - http://dx.plos.org/10.1371/journal.pone.0027130 DB - PRIME DP - Unbound Medicine ER -