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Measles antibodies and response to vaccination in children aged less than 14 months: implications for age of vaccination.
Epidemiol Infect. 2012 Sep; 140(9):1599-606.EI

Abstract

Passive immunity against measles decreases during the first months of life. The objective of this study was to determine titres of measles antibodies in children aged 9-14 months and their mothers before vaccination, and the children's response to vaccination. Blood samples were collected by capillary puncture before and 28 days after vaccination. Samples were obtained between February and June 2007 during an ongoing measles outbreak. Titres of specific measles IgG antibodies were determined by enzyme-linked immunosorbent assay. Seroconversion was defined as the presence of antibodies after vaccination in subjects without antibodies before vaccination. Maternal antibodies were present in 37·7% of all 69 children included and in 45·1% of children aged 9 months. Of the 51 children in whom a second sample was obtained, 31 (60·8%) were seronegative before vaccination and 61·3% seroconverted. Interference of maternal antibodies was 30%. Advancing the first dose of measles vaccination from 15 to 12 months is a correct strategy, given the increase in the time of susceptibility of infants to measles.

Authors+Show Affiliations

CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. eva.borras@gencat.catNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22074684

Citation

Borràs, E, et al. "Measles Antibodies and Response to Vaccination in Children Aged Less Than 14 Months: Implications for Age of Vaccination." Epidemiology and Infection, vol. 140, no. 9, 2012, pp. 1599-606.
Borràs E, Urbiztondo L, Costa J, et al. Measles antibodies and response to vaccination in children aged less than 14 months: implications for age of vaccination. Epidemiol Infect. 2012;140(9):1599-606.
Borràs, E., Urbiztondo, L., Costa, J., Batalla, J., Torner, N., Plasencia, A., Salleras, L., & Domínguez, À. (2012). Measles antibodies and response to vaccination in children aged less than 14 months: implications for age of vaccination. Epidemiology and Infection, 140(9), 1599-606.
Borràs E, et al. Measles Antibodies and Response to Vaccination in Children Aged Less Than 14 Months: Implications for Age of Vaccination. Epidemiol Infect. 2012;140(9):1599-606. PubMed PMID: 22074684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measles antibodies and response to vaccination in children aged less than 14 months: implications for age of vaccination. AU - Borràs,E, AU - Urbiztondo,L, AU - Costa,J, AU - Batalla,J, AU - Torner,N, AU - Plasencia,A, AU - Salleras,L, AU - Domínguez,À, AU - ,, Y1 - 2011/11/11/ PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/10/10/medline SP - 1599 EP - 606 JF - Epidemiology and infection JO - Epidemiol Infect VL - 140 IS - 9 N2 - Passive immunity against measles decreases during the first months of life. The objective of this study was to determine titres of measles antibodies in children aged 9-14 months and their mothers before vaccination, and the children's response to vaccination. Blood samples were collected by capillary puncture before and 28 days after vaccination. Samples were obtained between February and June 2007 during an ongoing measles outbreak. Titres of specific measles IgG antibodies were determined by enzyme-linked immunosorbent assay. Seroconversion was defined as the presence of antibodies after vaccination in subjects without antibodies before vaccination. Maternal antibodies were present in 37·7% of all 69 children included and in 45·1% of children aged 9 months. Of the 51 children in whom a second sample was obtained, 31 (60·8%) were seronegative before vaccination and 61·3% seroconverted. Interference of maternal antibodies was 30%. Advancing the first dose of measles vaccination from 15 to 12 months is a correct strategy, given the increase in the time of susceptibility of infants to measles. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/22074684/Measles_antibodies_and_response_to_vaccination_in_children_aged_less_than_14_months:_implications_for_age_of_vaccination_ L2 - https://www.cambridge.org/core/product/identifier/S0950268811002184/type/journal_article DB - PRIME DP - Unbound Medicine ER -