Tags

Type your tag names separated by a space and hit enter

Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies.

Abstract

OBJECTIVE

To investigate the association between intake of dietary fibre and whole grains and risk of colorectal cancer.

DESIGN

Systematic review and meta-analysis of prospective observational studies.

DATA SOURCES

PubMed and several other databases up to December 2010 and the reference lists of studies included in the analysis as well as those listed in published meta-analyses.

STUDY SELECTION

Prospective cohort and nested case-control studies of dietary fibre or whole grain intake and incidence of colorectal cancer.

RESULTS

25 prospective studies were included in the analysis. The summary relative risk of developing colorectal cancer for 10 g daily of total dietary fibre (16 studies) was 0.90 (95% confidence interval 0.86 to 0.94, I(2) = 0%), for fruit fibre (n = 9) was 0.93 (0.82 to 1.05, I(2) = 23%), for vegetable fibre (n = 9) was 0.98 (0.91 to 1.06, I(2) = 0%), for legume fibre (n = 4) was 0.62 (0.27 to 1.42, I(2) = 58%), and for cereal fibre (n = 8) was 0.90 (0.83 to 0.97, I(2) = 0%). The summary relative risk for an increment of three servings daily of whole grains (n = 6) was 0.83 (0.78 to 0.89, I(2) = 18%).

CONCLUSION

A high intake of dietary fibre, in particular cereal fibre and whole grains, was associated with a reduced risk of colorectal cancer. Further studies should report more detailed results, including those for subtypes of fibre and be stratified by other risk factors to rule out residual confounding. Further assessment of the impact of measurement errors on the risk estimates is also warranted.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, London W2 1PG, UK. d.aune@imperial.ac.uk

    , , , , ,

    Source

    BMJ (Clinical research ed.) 343: 2011 Nov 10 pg d6617

    MeSH

    Case-Control Studies
    Colorectal Neoplasms
    Dietary Fiber
    Edible Grain
    Feeding Behavior
    Humans
    Incidence
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    22074852

    Citation

    Aune, Dagfinn, et al. "Dietary Fibre, Whole Grains, and Risk of Colorectal Cancer: Systematic Review and Dose-response Meta-analysis of Prospective Studies." BMJ (Clinical Research Ed.), vol. 343, 2011, pp. d6617.
    Aune D, Chan DS, Lau R, et al. Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ. 2011;343:d6617.
    Aune, D., Chan, D. S., Lau, R., Vieira, R., Greenwood, D. C., Kampman, E., & Norat, T. (2011). Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ (Clinical Research Ed.), 343, pp. d6617. doi:10.1136/bmj.d6617.
    Aune D, et al. Dietary Fibre, Whole Grains, and Risk of Colorectal Cancer: Systematic Review and Dose-response Meta-analysis of Prospective Studies. BMJ. 2011 Nov 10;343:d6617. PubMed PMID: 22074852.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. AU - Aune,Dagfinn, AU - Chan,Doris S M, AU - Lau,Rosa, AU - Vieira,Rui, AU - Greenwood,Darren C, AU - Kampman,Ellen, AU - Norat,Teresa, Y1 - 2011/11/10/ PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2011/12/30/medline SP - d6617 EP - d6617 JF - BMJ (Clinical research ed.) JO - BMJ VL - 343 N2 - OBJECTIVE: To investigate the association between intake of dietary fibre and whole grains and risk of colorectal cancer. DESIGN: Systematic review and meta-analysis of prospective observational studies. DATA SOURCES: PubMed and several other databases up to December 2010 and the reference lists of studies included in the analysis as well as those listed in published meta-analyses. STUDY SELECTION: Prospective cohort and nested case-control studies of dietary fibre or whole grain intake and incidence of colorectal cancer. RESULTS: 25 prospective studies were included in the analysis. The summary relative risk of developing colorectal cancer for 10 g daily of total dietary fibre (16 studies) was 0.90 (95% confidence interval 0.86 to 0.94, I(2) = 0%), for fruit fibre (n = 9) was 0.93 (0.82 to 1.05, I(2) = 23%), for vegetable fibre (n = 9) was 0.98 (0.91 to 1.06, I(2) = 0%), for legume fibre (n = 4) was 0.62 (0.27 to 1.42, I(2) = 58%), and for cereal fibre (n = 8) was 0.90 (0.83 to 0.97, I(2) = 0%). The summary relative risk for an increment of three servings daily of whole grains (n = 6) was 0.83 (0.78 to 0.89, I(2) = 18%). CONCLUSION: A high intake of dietary fibre, in particular cereal fibre and whole grains, was associated with a reduced risk of colorectal cancer. Further studies should report more detailed results, including those for subtypes of fibre and be stratified by other risk factors to rule out residual confounding. Further assessment of the impact of measurement errors on the risk estimates is also warranted. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/22074852/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=22074852 DB - PRIME DP - Unbound Medicine ER -