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Competing risk of atherosclerotic risk factors for arterial and venous thrombosis in a general population: the Tromso study.
Arterioscler Thromb Vasc Biol 2012; 32(2):487-91AT

Abstract

OBJECTIVE

To investigate and compare the impact of traditional atherosclerotic risk factors for the risk of arterial and venous thrombosis, taking into account competing risks.

METHODS AND RESULTS

In 1994-1995, 26,185 subjects were screened in the Tromsø study. Information on traditional atherosclerotic risk factors was obtained by physical examination, blood samples, and questionnaires. Subjects were followed to the first incident event of myocardial infarction (MI) or venous thromboembolism (VTE), or December 31, 2005. During a median of 10.8 years of follow-up, there were 1279 cases of incident MI and 341 VTE events. Advancing age and high body mass index were both associated with MI and VTE. Hazard ratio per decade of age was 2.34 (95% CI: 2.25-2.43) for MI and 1.87 (1.74-2.01) for VTE, and 3 kg/m(2) increase in body mass index was associated with 1.16 (1.11-1.21) and 1.20 (1.12-1.29) increased risk of MI and VTE, respectively. Blood pressure, high levels of triglycerides and total cholesterol, low HDL cholesterol, self-reported diabetes, and smoking were all associated with increased risk of MI but not associated with VTE.

CONCLUSIONS

Our findings imply that traditional atherosclerotic risk factors, such as smoking, hypertension, dyslipidemia, and diabetes mellitus are not shared by arterial and venous thrombosis.

Authors+Show Affiliations

Hematological Research Group, Department of Clinical Medicine, University of Tromsø, N-9037 Tromsø, Norway. sigrid.brakkan@uit.no

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22075253

Citation

Brækkan, Sigrid K., et al. "Competing Risk of Atherosclerotic Risk Factors for Arterial and Venous Thrombosis in a General Population: the Tromso Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 2, 2012, pp. 487-91.
Brækkan SK, Hald EM, Mathiesen EB, et al. Competing risk of atherosclerotic risk factors for arterial and venous thrombosis in a general population: the Tromso study. Arterioscler Thromb Vasc Biol. 2012;32(2):487-91.
Brækkan, S. K., Hald, E. M., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., Rosendaal, F. R., & Hansen, J. B. (2012). Competing risk of atherosclerotic risk factors for arterial and venous thrombosis in a general population: the Tromso study. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(2), pp. 487-91. doi:10.1161/ATVBAHA.111.237545.
Brækkan SK, et al. Competing Risk of Atherosclerotic Risk Factors for Arterial and Venous Thrombosis in a General Population: the Tromso Study. Arterioscler Thromb Vasc Biol. 2012;32(2):487-91. PubMed PMID: 22075253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Competing risk of atherosclerotic risk factors for arterial and venous thrombosis in a general population: the Tromso study. AU - Brækkan,Sigrid K, AU - Hald,Erin M, AU - Mathiesen,Ellisiv B, AU - Njølstad,Inger, AU - Wilsgaard,Tom, AU - Rosendaal,Frits R, AU - Hansen,John-Bjarne, Y1 - 2011/11/10/ PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/3/14/medline SP - 487 EP - 91 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 32 IS - 2 N2 - OBJECTIVE: To investigate and compare the impact of traditional atherosclerotic risk factors for the risk of arterial and venous thrombosis, taking into account competing risks. METHODS AND RESULTS: In 1994-1995, 26,185 subjects were screened in the Tromsø study. Information on traditional atherosclerotic risk factors was obtained by physical examination, blood samples, and questionnaires. Subjects were followed to the first incident event of myocardial infarction (MI) or venous thromboembolism (VTE), or December 31, 2005. During a median of 10.8 years of follow-up, there were 1279 cases of incident MI and 341 VTE events. Advancing age and high body mass index were both associated with MI and VTE. Hazard ratio per decade of age was 2.34 (95% CI: 2.25-2.43) for MI and 1.87 (1.74-2.01) for VTE, and 3 kg/m(2) increase in body mass index was associated with 1.16 (1.11-1.21) and 1.20 (1.12-1.29) increased risk of MI and VTE, respectively. Blood pressure, high levels of triglycerides and total cholesterol, low HDL cholesterol, self-reported diabetes, and smoking were all associated with increased risk of MI but not associated with VTE. CONCLUSIONS: Our findings imply that traditional atherosclerotic risk factors, such as smoking, hypertension, dyslipidemia, and diabetes mellitus are not shared by arterial and venous thrombosis. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/22075253/Competing_risk_of_atherosclerotic_risk_factors_for_arterial_and_venous_thrombosis_in_a_general_population:_the_Tromso_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/ATVBAHA.111.237545?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -