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Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.
Life Sci. 2012 Jan 16; 90(3-4):147-53.LS

Abstract

AIMS

Recently, some studies reported that digestive tract disease is closely associated with atopic dermatitis (AD). Pyeongwee-San (KMP6) is a Korean medicine, which has come onto the drugstore for the treatment of digestive tract disease. The aim of the present study was to examine whether KMP6 could suppress 2,4-dinitrofluorobenzene (DNFB)-induced AD-like skin lesions in NC/Nga mice.

MAIN METHODS

Mice were sensitized with DNFB by applying to shaved dorsal skin. At that time, the drugs or saline were orally administrated to DNFB-applied mice.

KEY FINDINGS

The administration of KMP6 or glycyrrhizic acid (GL), a major component of KMP6, inhibited the scratching number in DNFB-induced AD model. The mRNA expressions of interleukin (IL)-4, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and CCR3 were upregulated by DNFB sensitization, but the upregulated mRNA expressions were significantly reduced by the administration of KMP6 or GL. In addition, the levels of IgE, histamine, and IL-4 were significantly reduced by the administration of KMP6 or GL in serum of DNFB-induced AD model. However, the level of IFN-γ in serum was significantly increased by KMP6 or GL. KMP6 or GL also significantly inhibited the numbers of inflammatory cells, mast cells, and protein level of IL-4 in lesions of DNFB-induced AD model. Finally, KMP6 or GL significantly decreased the productions of IL-4, IFN-γ, and TNF-α in anti-CD3 plus anti-CD28 antibody-stimulated splenocytes.

SIGNIFICANCE

KMP6 showed anti-atopic potential in this setting; hence we suggest it as a potential prospect for anti-atopic agent besides being just a medicine for the stomach and bowels.

Authors+Show Affiliations

Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22075493

Citation

Han, Na-Ra, et al. "Effect of Pyeongwee-San (KMP6) On 2,4-dinitrofluorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice." Life Sciences, vol. 90, no. 3-4, 2012, pp. 147-53.
Han NR, Moon PD, Kim HM, et al. Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Life Sci. 2012;90(3-4):147-53.
Han, N. R., Moon, P. D., Kim, H. M., & Jeong, H. J. (2012). Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Life Sciences, 90(3-4), 147-53. https://doi.org/10.1016/j.lfs.2011.10.015
Han NR, et al. Effect of Pyeongwee-San (KMP6) On 2,4-dinitrofluorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice. Life Sci. 2012 Jan 16;90(3-4):147-53. PubMed PMID: 22075493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. AU - Han,Na-Ra, AU - Moon,Phil-Dong, AU - Kim,Hyung-Min, AU - Jeong,Hyun-Ja, Y1 - 2011/10/29/ PY - 2011/07/13/received PY - 2011/10/17/revised PY - 2011/10/25/accepted PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/3/1/medline SP - 147 EP - 53 JF - Life sciences JO - Life Sci VL - 90 IS - 3-4 N2 - AIMS: Recently, some studies reported that digestive tract disease is closely associated with atopic dermatitis (AD). Pyeongwee-San (KMP6) is a Korean medicine, which has come onto the drugstore for the treatment of digestive tract disease. The aim of the present study was to examine whether KMP6 could suppress 2,4-dinitrofluorobenzene (DNFB)-induced AD-like skin lesions in NC/Nga mice. MAIN METHODS: Mice were sensitized with DNFB by applying to shaved dorsal skin. At that time, the drugs or saline were orally administrated to DNFB-applied mice. KEY FINDINGS: The administration of KMP6 or glycyrrhizic acid (GL), a major component of KMP6, inhibited the scratching number in DNFB-induced AD model. The mRNA expressions of interleukin (IL)-4, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and CCR3 were upregulated by DNFB sensitization, but the upregulated mRNA expressions were significantly reduced by the administration of KMP6 or GL. In addition, the levels of IgE, histamine, and IL-4 were significantly reduced by the administration of KMP6 or GL in serum of DNFB-induced AD model. However, the level of IFN-γ in serum was significantly increased by KMP6 or GL. KMP6 or GL also significantly inhibited the numbers of inflammatory cells, mast cells, and protein level of IL-4 in lesions of DNFB-induced AD model. Finally, KMP6 or GL significantly decreased the productions of IL-4, IFN-γ, and TNF-α in anti-CD3 plus anti-CD28 antibody-stimulated splenocytes. SIGNIFICANCE: KMP6 showed anti-atopic potential in this setting; hence we suggest it as a potential prospect for anti-atopic agent besides being just a medicine for the stomach and bowels. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/22075493/Effect_of_Pyeongwee_San__KMP6__on_24_dinitrofluorobenzene_induced_atopic_dermatitis_like_skin_lesions_in_NC/Nga_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(11)00520-0 DB - PRIME DP - Unbound Medicine ER -