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Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation.
Int J Mol Med. 2012 Feb; 29(2):303-10.IJ

Abstract

In this study, we investigated the effect of a water extract of the ripe fruits of Rubus coreanus Miq. (Rosaceae) (RFRC) on mast cell-mediated allergic inflammation and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as anaphylaxis, rhinitis, asthma and atopic dermatitis. RFRC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. RFRC reduced the immunoglobulin E (IgE)-mediated local allergic reaction, passive cutaneous anaphylaxis. RFRC attenuated histamine release from rat peritoneal mast cells and human mast cells by the reduction of intracellular calcium. RFRC decreased the phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines in human mast cells. The inhibitory effect of RFRC on cytokine production was nuclear factor (NF)-κB- and mitogen-activated protein kinase (MAPK)-dependent. In addition, RFRC suppressed the activation of caspase-1. Our findings provide evidence that RFRC inhibits mast cell-derived allergic inflammatory reactions, and for the involvement of calcium, NF-κB, MAPKs and caspase-1 in these effects. Furthermore, in vivo and in vitro anti-allergic inflammatory effects of RFRC provide affirmative proof of a possible therapeutic application of this agent in allergic inflammatory diseases.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22075758

Citation

Kim, Hui-Hun, et al. "Ripe Fruit of Rubus Coreanus Inhibits Mast Cell-mediated Allergic Inflammation." International Journal of Molecular Medicine, vol. 29, no. 2, 2012, pp. 303-10.
Kim HH, Choi PH, Yoo JS, et al. Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation. Int J Mol Med. 2012;29(2):303-10.
Kim, H. H., Choi, P. H., Yoo, J. S., Jeon, H., Chae, B. S., Park, J. S., Kim, S. H., & Shin, T. Y. (2012). Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation. International Journal of Molecular Medicine, 29(2), 303-10. https://doi.org/10.3892/ijmm.2011.829
Kim HH, et al. Ripe Fruit of Rubus Coreanus Inhibits Mast Cell-mediated Allergic Inflammation. Int J Mol Med. 2012;29(2):303-10. PubMed PMID: 22075758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation. AU - Kim,Hui-Hun, AU - Choi,Phil Hyung, AU - Yoo,Jin-Su, AU - Jeon,Hoon, AU - Chae,Byeong-Suk, AU - Park,Jeong-Suk, AU - Kim,Sang-Hyun, AU - Shin,Tae-Yong, Y1 - 2011/11/07/ PY - 2011/08/31/received PY - 2011/10/04/accepted PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/4/14/medline SP - 303 EP - 10 JF - International journal of molecular medicine JO - Int J Mol Med VL - 29 IS - 2 N2 - In this study, we investigated the effect of a water extract of the ripe fruits of Rubus coreanus Miq. (Rosaceae) (RFRC) on mast cell-mediated allergic inflammation and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as anaphylaxis, rhinitis, asthma and atopic dermatitis. RFRC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. RFRC reduced the immunoglobulin E (IgE)-mediated local allergic reaction, passive cutaneous anaphylaxis. RFRC attenuated histamine release from rat peritoneal mast cells and human mast cells by the reduction of intracellular calcium. RFRC decreased the phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines in human mast cells. The inhibitory effect of RFRC on cytokine production was nuclear factor (NF)-κB- and mitogen-activated protein kinase (MAPK)-dependent. In addition, RFRC suppressed the activation of caspase-1. Our findings provide evidence that RFRC inhibits mast cell-derived allergic inflammatory reactions, and for the involvement of calcium, NF-κB, MAPKs and caspase-1 in these effects. Furthermore, in vivo and in vitro anti-allergic inflammatory effects of RFRC provide affirmative proof of a possible therapeutic application of this agent in allergic inflammatory diseases. SN - 1791-244X UR - https://www.unboundmedicine.com/medline/citation/22075758/Ripe_fruit_of_Rubus_coreanus_inhibits_mast_cell_mediated_allergic_inflammation_ L2 - http://www.spandidos-publications.com/ijmm/29/2/303 DB - PRIME DP - Unbound Medicine ER -