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Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin.
Biomacromolecules. 2011 Dec 12; 12(12):4335-43.B

Abstract

Nanogels based on the polymers of galactosylated chitosan-graft-poly (N-isopropylacrylamide) (Gal-CS-g-PNIPAm) were used as carriers of oridonin (ORI) for tumor targeting. Three ORI-loaded nanogels with various degrees of galactose substitution were prepared, and their characteristics were evaluated. The release behavior of ORI from these nanogels was pH-dependent, and the release could be accelerated under mildly acidic conditions. The cytotoxicity of ORI-loaded nanogels was pH-sensitive. ORI-loaded nanogels exhibited a higher antitumor activity than drug-loaded nanogels without galactosylation, and the anticancer activity increased in relation to increases in the number of galactose moieties of the nanogels in HepG2 cells. In contrast, the cytotoxicity of ORI-loaded nanogels against MCF-7 cells decreased compared with that of drug-loaded nanogels without galactosylation. Results demonstrated that these nanogels could enhance the uptake of ORI into HepG2 cells via asialoglycoprotein receptor-mediated endocytosis. These galactose-decorated pH-responsive nanogels were well-suited for targeted drug delivery to liver cancer cells.

Authors+Show Affiliations

Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, Jinan, P R China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22077387

Citation

Duan, Cunxian, et al. "Galactose-decorated pH-responsive Nanogels for Hepatoma-targeted Delivery of Oridonin." Biomacromolecules, vol. 12, no. 12, 2011, pp. 4335-43.
Duan C, Gao J, Zhang D, et al. Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin. Biomacromolecules. 2011;12(12):4335-43.
Duan, C., Gao, J., Zhang, D., Jia, L., Liu, Y., Zheng, D., Liu, G., Tian, X., Wang, F., & Zhang, Q. (2011). Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin. Biomacromolecules, 12(12), 4335-43. https://doi.org/10.1021/bm201270m
Duan C, et al. Galactose-decorated pH-responsive Nanogels for Hepatoma-targeted Delivery of Oridonin. Biomacromolecules. 2011 Dec 12;12(12):4335-43. PubMed PMID: 22077387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin. AU - Duan,Cunxian, AU - Gao,Jian, AU - Zhang,Dianrui, AU - Jia,Lejiao, AU - Liu,Yue, AU - Zheng,Dandan, AU - Liu,Guangpu, AU - Tian,Xiaona, AU - Wang,Fengshan, AU - Zhang,Qiang, Y1 - 2011/11/16/ PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/6/12/medline SP - 4335 EP - 43 JF - Biomacromolecules JO - Biomacromolecules VL - 12 IS - 12 N2 - Nanogels based on the polymers of galactosylated chitosan-graft-poly (N-isopropylacrylamide) (Gal-CS-g-PNIPAm) were used as carriers of oridonin (ORI) for tumor targeting. Three ORI-loaded nanogels with various degrees of galactose substitution were prepared, and their characteristics were evaluated. The release behavior of ORI from these nanogels was pH-dependent, and the release could be accelerated under mildly acidic conditions. The cytotoxicity of ORI-loaded nanogels was pH-sensitive. ORI-loaded nanogels exhibited a higher antitumor activity than drug-loaded nanogels without galactosylation, and the anticancer activity increased in relation to increases in the number of galactose moieties of the nanogels in HepG2 cells. In contrast, the cytotoxicity of ORI-loaded nanogels against MCF-7 cells decreased compared with that of drug-loaded nanogels without galactosylation. Results demonstrated that these nanogels could enhance the uptake of ORI into HepG2 cells via asialoglycoprotein receptor-mediated endocytosis. These galactose-decorated pH-responsive nanogels were well-suited for targeted drug delivery to liver cancer cells. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/22077387/Galactose_decorated_pH_responsive_nanogels_for_hepatoma_targeted_delivery_of_oridonin_ L2 - https://dx.doi.org/10.1021/bm201270m DB - PRIME DP - Unbound Medicine ER -