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Antioxidant and antipyretic studies on Pothos scandens L.
Asian Pac J Trop Med. 2011 Nov; 4(11):889-99.AP

Abstract

OBJECTIVE

To investigate Pothos scandens for the in vitro antioxidant and antipyretic activity.

METHODS

Preliminary phytochemicals, total phenolics and flavonoid contents were analyzed in leaf, stem and root samples. In vitro antioxidant activity was evaluated by different assays such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2, 2'-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS•+) radical scavenging, ferric-reducing antioxidant power (FRAP) assay, phosphomolybdenum reduction assay, metal chelating activity, superoxide anion radical scavenging activity, hydrogen peroxide and nitric oxide scavenging assay. The antipyretic activity of root methanol extract was studied by pyrexia induced by brewer's yeast on Wistar albino rats at concentration of 200 and 400 mg/kg using paracetamol as standard drug.

RESULTS

The total phenolics and tannin content were found to be higher in ethanol extract of stem, whereas total flavonoid content was higher in acetone extract of root. The methanol extract of root showed highest free radical scavenging activity in assays namely ABTS assay (8 221.5 μM TE/g extract), FRAP assay [514.4 mM Fe (II)/g extract], hydrogen peroxide (60.3%) and nitric oxide scavenging assays (58.7%). The DPPH assay and superoxide radical assay results revealed that the ethanol extract of root has remarkable free radical scavenging capacity (IC50 0.284 mg/mL and 70.84%). The antipyretic studies on methanol extract of root showed significant reduction of temperature in pyrexia induced rats at 200 and 400 mg/kg doses.

CONCLUSIONS

These findings justify that Pothos scandens can be a valuable natural antioxidant and antipyretic source which seemed to provide potential nutraceuticals for human health.

Authors+Show Affiliations

Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22078952

Citation

Sajeesh, Thankarajan, et al. "Antioxidant and Antipyretic Studies On Pothos Scandens L." Asian Pacific Journal of Tropical Medicine, vol. 4, no. 11, 2011, pp. 889-99.
Sajeesh T, Arunachalam K, Parimelazhagan T. Antioxidant and antipyretic studies on Pothos scandens L. Asian Pac J Trop Med. 2011;4(11):889-99.
Sajeesh, T., Arunachalam, K., & Parimelazhagan, T. (2011). Antioxidant and antipyretic studies on Pothos scandens L. Asian Pacific Journal of Tropical Medicine, 4(11), 889-99. https://doi.org/10.1016/S1995-7645(11)60214-9
Sajeesh T, Arunachalam K, Parimelazhagan T. Antioxidant and Antipyretic Studies On Pothos Scandens L. Asian Pac J Trop Med. 2011;4(11):889-99. PubMed PMID: 22078952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and antipyretic studies on Pothos scandens L. AU - Sajeesh,Thankarajan, AU - Arunachalam,Karuppusamy, AU - Parimelazhagan,Tangaraj, PY - 2011/06/01/received PY - 2011/08/15/revised PY - 2011/08/15/accepted PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/3/23/medline SP - 889 EP - 99 JF - Asian Pacific journal of tropical medicine JO - Asian Pac J Trop Med VL - 4 IS - 11 N2 - OBJECTIVE: To investigate Pothos scandens for the in vitro antioxidant and antipyretic activity. METHODS: Preliminary phytochemicals, total phenolics and flavonoid contents were analyzed in leaf, stem and root samples. In vitro antioxidant activity was evaluated by different assays such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2, 2'-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS•+) radical scavenging, ferric-reducing antioxidant power (FRAP) assay, phosphomolybdenum reduction assay, metal chelating activity, superoxide anion radical scavenging activity, hydrogen peroxide and nitric oxide scavenging assay. The antipyretic activity of root methanol extract was studied by pyrexia induced by brewer's yeast on Wistar albino rats at concentration of 200 and 400 mg/kg using paracetamol as standard drug. RESULTS: The total phenolics and tannin content were found to be higher in ethanol extract of stem, whereas total flavonoid content was higher in acetone extract of root. The methanol extract of root showed highest free radical scavenging activity in assays namely ABTS assay (8 221.5 μM TE/g extract), FRAP assay [514.4 mM Fe (II)/g extract], hydrogen peroxide (60.3%) and nitric oxide scavenging assays (58.7%). The DPPH assay and superoxide radical assay results revealed that the ethanol extract of root has remarkable free radical scavenging capacity (IC50 0.284 mg/mL and 70.84%). The antipyretic studies on methanol extract of root showed significant reduction of temperature in pyrexia induced rats at 200 and 400 mg/kg doses. CONCLUSIONS: These findings justify that Pothos scandens can be a valuable natural antioxidant and antipyretic source which seemed to provide potential nutraceuticals for human health. SN - 2352-4146 UR - https://www.unboundmedicine.com/medline/citation/22078952/Antioxidant_and_antipyretic_studies_on_Pothos_scandens_L_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1995-7645(11)60214-9 DB - PRIME DP - Unbound Medicine ER -