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The role of oxidized phospholipids, lipoprotein (a) and biomarkers of oxidized lipoproteins in chronically occluded coronary arteries in sudden cardiac death and following successful percutaneous revascularization.
Cardiovasc Revasc Med. 2012 Jan-Feb; 13(1):11-9.CR

Abstract

AIMS

OxPL are pro-inflammatory and may mediate atherogenesis, thrombosis and endothelial dysfunction. We studied the histological presence and temporal increases in oxidized phospholipids on apolipoprotein B-100 particles (OxPL/apoB), lipoprotein (a) [Lp(a)] and biomarkers of oxidized lipoproteins in subjects with chronic total coronary occlusions (CTO) with sudden cardiac death (SCD) and following percutaneous coronary intervention (PCI).

METHODS

Eight subjects with SCD and CTO and 33 patients with successful PCI of CTO were included. Blood samples were drawn before PCI, immediately post-PCI, at 6 and 24 h, at 3 days and at 1 week. Plasma levels of OxPL/apoB, Lp(a), IgG and IgM autoantibodies to malondialdehyde (MDA) low-density lipoprotein and apoB-immune complexes were measured in all samples and compared with previous data from 141 patients undergoing PCI of non-CTO vessels.

RESULTS

Immunohistochemistry of coronary CTOs revealed OxPL and MDA-like epitopes, particularly in areas of recanalized and organized thrombus and neovascularization. Following PCI, OxPL/apoB and Lp(a) levels, expressed as percent change from baseline levels before PCI, rose gradually and progressively over the next 7 days. In contrast, levels of OxPL/apoB and Lp(a) in non-CTO vessels rose immediately post PCI and then dropped rapidly to baseline within 24 h.

CONCLUSIONS

CTOs contain immunohistological evidence of OxPL and MDA-like epitopes. Successful PCI of CTOs results in a slower increase in OxPL/apoB and Lp(a) but higher increase in IgM immune complexes compared to non-CTO vessels. Pro-inflammatory oxidation-specific epitopes may impact development of CTOs and affect outcomes following PCI that can be evaluated in larger clinical trials.

Authors+Show Affiliations

Schulich Heart Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M4N 3M5.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22079685

Citation

Fefer, Paul, et al. "The Role of Oxidized Phospholipids, Lipoprotein (a) and Biomarkers of Oxidized Lipoproteins in Chronically Occluded Coronary Arteries in Sudden Cardiac Death and Following Successful Percutaneous Revascularization." Cardiovascular Revascularization Medicine : Including Molecular Interventions, vol. 13, no. 1, 2012, pp. 11-9.
Fefer P, Tsimikas S, Segev A, et al. The role of oxidized phospholipids, lipoprotein (a) and biomarkers of oxidized lipoproteins in chronically occluded coronary arteries in sudden cardiac death and following successful percutaneous revascularization. Cardiovasc Revasc Med. 2012;13(1):11-9.
Fefer, P., Tsimikas, S., Segev, A., Sparkes, J., Otsuka, F., Otsuma, F., Kolodgie, F., Virmani, R., Juliano, J., Charron, T., & Strauss, B. H. (2012). The role of oxidized phospholipids, lipoprotein (a) and biomarkers of oxidized lipoproteins in chronically occluded coronary arteries in sudden cardiac death and following successful percutaneous revascularization. Cardiovascular Revascularization Medicine : Including Molecular Interventions, 13(1), 11-9. https://doi.org/10.1016/j.carrev.2011.08.001
Fefer P, et al. The Role of Oxidized Phospholipids, Lipoprotein (a) and Biomarkers of Oxidized Lipoproteins in Chronically Occluded Coronary Arteries in Sudden Cardiac Death and Following Successful Percutaneous Revascularization. Cardiovasc Revasc Med. 2012 Jan-Feb;13(1):11-9. PubMed PMID: 22079685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of oxidized phospholipids, lipoprotein (a) and biomarkers of oxidized lipoproteins in chronically occluded coronary arteries in sudden cardiac death and following successful percutaneous revascularization. AU - Fefer,Paul, AU - Tsimikas,Sotirios, AU - Segev,Amit, AU - Sparkes,John, AU - Otsuka,Fumiyuki, AU - Otsuma,Fumiyuki, AU - Kolodgie,Frank, AU - Virmani,Renu, AU - Juliano,Joseph, AU - Charron,Thierry, AU - Strauss,Bradley H, Y1 - 2011/11/13/ PY - 2011/04/17/received PY - 2011/08/05/revised PY - 2011/08/15/accepted PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/10/30/medline SP - 11 EP - 9 JF - Cardiovascular revascularization medicine : including molecular interventions JO - Cardiovasc Revasc Med VL - 13 IS - 1 N2 - AIMS: OxPL are pro-inflammatory and may mediate atherogenesis, thrombosis and endothelial dysfunction. We studied the histological presence and temporal increases in oxidized phospholipids on apolipoprotein B-100 particles (OxPL/apoB), lipoprotein (a) [Lp(a)] and biomarkers of oxidized lipoproteins in subjects with chronic total coronary occlusions (CTO) with sudden cardiac death (SCD) and following percutaneous coronary intervention (PCI). METHODS: Eight subjects with SCD and CTO and 33 patients with successful PCI of CTO were included. Blood samples were drawn before PCI, immediately post-PCI, at 6 and 24 h, at 3 days and at 1 week. Plasma levels of OxPL/apoB, Lp(a), IgG and IgM autoantibodies to malondialdehyde (MDA) low-density lipoprotein and apoB-immune complexes were measured in all samples and compared with previous data from 141 patients undergoing PCI of non-CTO vessels. RESULTS: Immunohistochemistry of coronary CTOs revealed OxPL and MDA-like epitopes, particularly in areas of recanalized and organized thrombus and neovascularization. Following PCI, OxPL/apoB and Lp(a) levels, expressed as percent change from baseline levels before PCI, rose gradually and progressively over the next 7 days. In contrast, levels of OxPL/apoB and Lp(a) in non-CTO vessels rose immediately post PCI and then dropped rapidly to baseline within 24 h. CONCLUSIONS: CTOs contain immunohistological evidence of OxPL and MDA-like epitopes. Successful PCI of CTOs results in a slower increase in OxPL/apoB and Lp(a) but higher increase in IgM immune complexes compared to non-CTO vessels. Pro-inflammatory oxidation-specific epitopes may impact development of CTOs and affect outcomes following PCI that can be evaluated in larger clinical trials. SN - 1878-0938 UR - https://www.unboundmedicine.com/medline/citation/22079685/The_role_of_oxidized_phospholipids_lipoprotein__a__and_biomarkers_of_oxidized_lipoproteins_in_chronically_occluded_coronary_arteries_in_sudden_cardiac_death_and_following_successful_percutaneous_revascularization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1553-8389(11)00501-X DB - PRIME DP - Unbound Medicine ER -