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Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems.
Bioorg Med Chem Lett. 2012 Jan 01; 22(1):597-600.BM

Abstract

Thirteen gallic acid derivatives including five new gallotannins, named maplexins A-E, were isolated from red maple (Acer rubrum) stems. The compounds were identified by spectral analyses. The maplexins varied in number and location of galloyl groups attached to 1,5-anhydro-d-glucitol. The isolates were evaluated for α-glucosidase inhibitory and antioxidant activities. Maplexin E, the first compound identified with three galloyl groups linked to three different positions of 1,5-anhydro-d-glucitol, was 20 fold more potent than the α-glucosidase inhibitory drug, Acarbose (IC(50)=8 vs 160 μM). Structure-activity related studies suggested that both number and position of galloyls attached to 1,5-anhydro-d-glucitol were important for α-glucosidase inhibition.

Authors+Show Affiliations

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22079755

Citation

Wan, Chunpeng, et al. "Maplexins, New Α-glucosidase Inhibitors From Red Maple (Acer Rubrum) Stems." Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 1, 2012, pp. 597-600.
Wan C, Yuan T, Li L, et al. Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems. Bioorg Med Chem Lett. 2012;22(1):597-600.
Wan, C., Yuan, T., Li, L., Kandhi, V., Cech, N. B., Xie, M., & Seeram, N. P. (2012). Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems. Bioorganic & Medicinal Chemistry Letters, 22(1), 597-600. https://doi.org/10.1016/j.bmcl.2011.10.073
Wan C, et al. Maplexins, New Α-glucosidase Inhibitors From Red Maple (Acer Rubrum) Stems. Bioorg Med Chem Lett. 2012 Jan 1;22(1):597-600. PubMed PMID: 22079755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems. AU - Wan,Chunpeng, AU - Yuan,Tao, AU - Li,Liya, AU - Kandhi,Vamsikrishna, AU - Cech,Nadja B, AU - Xie,Mingyong, AU - Seeram,Navindra P, Y1 - 2011/10/28/ PY - 2011/10/06/received PY - 2011/10/20/revised PY - 2011/10/21/accepted PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/8/4/medline SP - 597 EP - 600 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 22 IS - 1 N2 - Thirteen gallic acid derivatives including five new gallotannins, named maplexins A-E, were isolated from red maple (Acer rubrum) stems. The compounds were identified by spectral analyses. The maplexins varied in number and location of galloyl groups attached to 1,5-anhydro-d-glucitol. The isolates were evaluated for α-glucosidase inhibitory and antioxidant activities. Maplexin E, the first compound identified with three galloyl groups linked to three different positions of 1,5-anhydro-d-glucitol, was 20 fold more potent than the α-glucosidase inhibitory drug, Acarbose (IC(50)=8 vs 160 μM). Structure-activity related studies suggested that both number and position of galloyls attached to 1,5-anhydro-d-glucitol were important for α-glucosidase inhibition. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/22079755/Maplexins_new_α_glucosidase_inhibitors_from_red_maple__Acer_rubrum__stems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(11)01471-5 DB - PRIME DP - Unbound Medicine ER -