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The level of arabinitol in autistic children after probiotic therapy.

Abstract

OBJECTIVE

The level of D-arabinitol (DA) and the ratio of D-/L-arabinitol (DA/LA) in the urine of children with autism were investigated. The changes in DA/LA after probiotic treatment in urine samples of children with autism were studied.

METHODS

DA and LA and the DA/LA ratio were identified by capillary gas chromatography/mass spectrometry in urine before and after the probiotic therapy.

RESULTS

The level of DA is significantly higher (P < 0.05) in the urine of autistic children before (A) and after probiotic supplementation (A1) (160.04 ± 22.88 μmol/mmol creatinine and 89.53 ± 37.41 μmol/mmol creatinine, respectively). Nonetheless, the probiotic supplementation let to a significant decrease in DA and DA/LA and to a significant improvement in ability of concentration and carrying out orders.

CONCLUSION

The use of probiotics seems to be helpful in reducing the level of DA and the ratio of DA/LA in the urine of children with autism.

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    MeSH

    Attention
    Autistic Disorder
    Candidiasis
    Child
    Child Behavior
    Child, Preschool
    Dietary Supplements
    Female
    Gas Chromatography-Mass Spectrometry
    Humans
    Isomerism
    Male
    Probiotics
    Sugar Alcohols

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22079796

    Citation

    TY - JOUR T1 - The level of arabinitol in autistic children after probiotic therapy. AU - Kałużna-Czaplińska,Joanna, AU - Błaszczyk,Sylwia, Y1 - 2011/11/12/ PY - 2010/11/3/received PY - 2011/8/1/revised PY - 2011/8/1/accepted PY - 2011/11/12/aheadofprint PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2012/6/6/medline SP - 124 EP - 6 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 28 IS - 2 N2 - OBJECTIVE: The level of D-arabinitol (DA) and the ratio of D-/L-arabinitol (DA/LA) in the urine of children with autism were investigated. The changes in DA/LA after probiotic treatment in urine samples of children with autism were studied. METHODS: DA and LA and the DA/LA ratio were identified by capillary gas chromatography/mass spectrometry in urine before and after the probiotic therapy. RESULTS: The level of DA is significantly higher (P < 0.05) in the urine of autistic children before (A) and after probiotic supplementation (A1) (160.04 ± 22.88 μmol/mmol creatinine and 89.53 ± 37.41 μmol/mmol creatinine, respectively). Nonetheless, the probiotic supplementation let to a significant decrease in DA and DA/LA and to a significant improvement in ability of concentration and carrying out orders. CONCLUSION: The use of probiotics seems to be helpful in reducing the level of DA and the ratio of DA/LA in the urine of children with autism. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/22079796/The_level_of_arabinitol_in_autistic_children_after_probiotic_therapy L2 - http://linkinghub.elsevier.com/retrieve/pii/S0899-9007(11)00261-9 ER -