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The influence of the intensity of smoking and years of work in the metallurgy on pro-oxidant/antioxidant balance in the blood of smelters.
Toxicol Ind Health 2013; 29(2):149-61TI

Abstract

The aim of this study was to investigate the effect of cigarette smoking and occupational exposure to heavy metals on the degree of pro-oxidant/antioxidant imbalance in smelters. The investigations were performed on the blood and urine of 400 subjects: 300 male copper smelters and 100 nonexposed male subjects. Biological material was divided into three groups: nonsmokers, those who smoked less than 20 cigarettes a day and those who smoked more than 20 cigarettes a day. The results showed a significant increase in the concentration of lead, cadmium and arsenic in the blood and urine of smelters, while smoking more than 20 cigarettes a day caused a further increase in the concentration of these metals. The level of malondialdehyde was approximately twofold higher in the plasma of the smelters compared to the control group. We have observed a disturbance in the level of antioxidants in erythrocyte lysate manifested by an increase in metallothionein and glutathione concentrations as well as superoxide dismutase and glutathione peroxidase activities and the decrease in glutathione S-transferase activity. Cigarette smoking, years of work in metallurgy and age of smelters were additional factors significantly affecting the pro-oxidant/antioxidant balance.

Authors+Show Affiliations

Department of Biomedical and Environmental Analyses, Wroclaw University of Medicine, Wroclaw, Poland. a_bizon@op.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22080035

Citation

Bizon, Anna, et al. "The Influence of the Intensity of Smoking and Years of Work in the Metallurgy On Pro-oxidant/antioxidant Balance in the Blood of Smelters." Toxicology and Industrial Health, vol. 29, no. 2, 2013, pp. 149-61.
Bizon A, Antonowicz-Juchniewicz J, Andrzejak R, et al. The influence of the intensity of smoking and years of work in the metallurgy on pro-oxidant/antioxidant balance in the blood of smelters. Toxicol Ind Health. 2013;29(2):149-61.
Bizon, A., Antonowicz-Juchniewicz, J., Andrzejak, R., & Milnerowicz, H. (2013). The influence of the intensity of smoking and years of work in the metallurgy on pro-oxidant/antioxidant balance in the blood of smelters. Toxicology and Industrial Health, 29(2), pp. 149-61. doi:10.1177/0748233711427054.
Bizon A, et al. The Influence of the Intensity of Smoking and Years of Work in the Metallurgy On Pro-oxidant/antioxidant Balance in the Blood of Smelters. Toxicol Ind Health. 2013;29(2):149-61. PubMed PMID: 22080035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of the intensity of smoking and years of work in the metallurgy on pro-oxidant/antioxidant balance in the blood of smelters. AU - Bizon,Anna, AU - Antonowicz-Juchniewicz,Jolanta, AU - Andrzejak,Ryszard, AU - Milnerowicz,Halina, Y1 - 2011/11/11/ PY - 2011/11/15/entrez PY - 2011/11/15/pubmed PY - 2013/8/14/medline SP - 149 EP - 61 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 29 IS - 2 N2 - The aim of this study was to investigate the effect of cigarette smoking and occupational exposure to heavy metals on the degree of pro-oxidant/antioxidant imbalance in smelters. The investigations were performed on the blood and urine of 400 subjects: 300 male copper smelters and 100 nonexposed male subjects. Biological material was divided into three groups: nonsmokers, those who smoked less than 20 cigarettes a day and those who smoked more than 20 cigarettes a day. The results showed a significant increase in the concentration of lead, cadmium and arsenic in the blood and urine of smelters, while smoking more than 20 cigarettes a day caused a further increase in the concentration of these metals. The level of malondialdehyde was approximately twofold higher in the plasma of the smelters compared to the control group. We have observed a disturbance in the level of antioxidants in erythrocyte lysate manifested by an increase in metallothionein and glutathione concentrations as well as superoxide dismutase and glutathione peroxidase activities and the decrease in glutathione S-transferase activity. Cigarette smoking, years of work in metallurgy and age of smelters were additional factors significantly affecting the pro-oxidant/antioxidant balance. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/22080035/The_influence_of_the_intensity_of_smoking_and_years_of_work_in_the_metallurgy_on_pro_oxidant/antioxidant_balance_in_the_blood_of_smelters_ L2 - http://journals.sagepub.com/doi/full/10.1177/0748233711427054?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -