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Cranberry proanthocyanidins: natural weapons against periodontal diseases.
J Agric Food Chem 2012; 60(23):5728-35JA

Abstract

Cranberry (Vaccinium macrocarpon) is known to have a beneficial effect on several aspects of human health. Proanthocyanidins (PACs), the most abundant flavonoids extracted from red cranberry fruits, have been reported to possess antimicrobial, antiadhesion, antioxidant, and anti-inflammatory properties. Recent in vitro studies have shown that cranberry PACs may be potential therapeutic agents for the prevention and management of periodontitis, an inflammatory disease of bacterial origin affecting tooth-supporting tissues. After presenting an overview of cranberry phytochemicals and their potential for human health benefits, this review will focus on the effects of cranberry PACs on connective tissue breakdown and alveolar bone destruction, as well as their potential for controlling periodontal diseases. Possible mechanisms of action of cranberry PACs include the inhibition of (i) bacterial and host-derived proteolytic enzymes, (ii) host inflammatory response, and (iii) osteoclast differentiation and activity. Given that cranberry PACs have shown interesting properties in in vitro studies, clinical trials are warranted to better evaluate the potential of these molecules for controlling periodontal diseases.

Authors+Show Affiliations

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval , Quebec City, QC, Canada G1V 0A6.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22082264

Citation

Feghali, Karine, et al. "Cranberry Proanthocyanidins: Natural Weapons Against Periodontal Diseases." Journal of Agricultural and Food Chemistry, vol. 60, no. 23, 2012, pp. 5728-35.
Feghali K, Feldman M, La VD, et al. Cranberry proanthocyanidins: natural weapons against periodontal diseases. J Agric Food Chem. 2012;60(23):5728-35.
Feghali, K., Feldman, M., La, V. D., Santos, J., & Grenier, D. (2012). Cranberry proanthocyanidins: natural weapons against periodontal diseases. Journal of Agricultural and Food Chemistry, 60(23), pp. 5728-35. doi:10.1021/jf203304v.
Feghali K, et al. Cranberry Proanthocyanidins: Natural Weapons Against Periodontal Diseases. J Agric Food Chem. 2012 Jun 13;60(23):5728-35. PubMed PMID: 22082264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cranberry proanthocyanidins: natural weapons against periodontal diseases. AU - Feghali,Karine, AU - Feldman,Mark, AU - La,Vu Dang, AU - Santos,Juliana, AU - Grenier,Daniel, Y1 - 2011/11/29/ PY - 2011/11/16/entrez PY - 2011/11/16/pubmed PY - 2014/7/19/medline SP - 5728 EP - 35 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 60 IS - 23 N2 - Cranberry (Vaccinium macrocarpon) is known to have a beneficial effect on several aspects of human health. Proanthocyanidins (PACs), the most abundant flavonoids extracted from red cranberry fruits, have been reported to possess antimicrobial, antiadhesion, antioxidant, and anti-inflammatory properties. Recent in vitro studies have shown that cranberry PACs may be potential therapeutic agents for the prevention and management of periodontitis, an inflammatory disease of bacterial origin affecting tooth-supporting tissues. After presenting an overview of cranberry phytochemicals and their potential for human health benefits, this review will focus on the effects of cranberry PACs on connective tissue breakdown and alveolar bone destruction, as well as their potential for controlling periodontal diseases. Possible mechanisms of action of cranberry PACs include the inhibition of (i) bacterial and host-derived proteolytic enzymes, (ii) host inflammatory response, and (iii) osteoclast differentiation and activity. Given that cranberry PACs have shown interesting properties in in vitro studies, clinical trials are warranted to better evaluate the potential of these molecules for controlling periodontal diseases. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/22082264/Cranberry_proanthocyanidins:_natural_weapons_against_periodontal_diseases_ L2 - https://dx.doi.org/10.1021/jf203304v DB - PRIME DP - Unbound Medicine ER -