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Anti-inflammatory and antioxidant effects of infliximab in a rat model of intestinal ischemia/reperfusion injury.
Toxicol Ind Health. 2012 Nov; 28(10):923-32.TI

Abstract

The aim of this study was to investigate the possible protective effects of infliximab on oxidative stress, cell proliferation and apoptosis in the rat intestinal mucosa after ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: sham, I/R and I/R+ infliximab; each group comprised 10 animals. Sham group animals underwent laparotomy without I/R injury. I/R groups after undergoing laparotomy, 1 hour of superior mesenteric artery ligation occurred, which was followed by 1 hour of reperfusion. In the infliximab group, 3 days before I/R, infliximab (3 mg/kg) was administered intravenously. All animals were killed at the end of reperfusion and intestinal tissues samples were obtained for biochemical and histopathological investigation in all groups. To date, no biochemical and histopathological changes have been reported regarding intestinal I/R injury in rats due to infliximab treatment. Infliximab treatment significantly decreased the elevated tissue malondialdehyde levels and increased reduced superoxide dismutase and glutathione peroxidase enzyme activities in intestinal tissues samples. I/R caused severe histopathological injury including mucosal erosions, inflammatory cell infiltration, necrosis, hemorrhage, and villous congestion. Infliximab treatment significantly attenuated the severity of intestinal I/R injury, inhibiting I/R-induced apoptosis, and cell proliferation. Because of its anti-inflammatory and antioxidant effects, infliximab pretreatment may have protective effects on the experimental intestinal I/R model of rats.

Authors+Show Affiliations

Department of Surgery, Faculty of Medicine, Rize University, Rize, Turkey. pergelahmet@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22082824

Citation

Pergel, Ahmet, et al. "Anti-inflammatory and Antioxidant Effects of Infliximab in a Rat Model of Intestinal Ischemia/reperfusion Injury." Toxicology and Industrial Health, vol. 28, no. 10, 2012, pp. 923-32.
Pergel A, Kanter M, Yucel AF, et al. Anti-inflammatory and antioxidant effects of infliximab in a rat model of intestinal ischemia/reperfusion injury. Toxicol Ind Health. 2012;28(10):923-32.
Pergel, A., Kanter, M., Yucel, A. F., Aydin, I., Erboga, M., & Guzel, A. (2012). Anti-inflammatory and antioxidant effects of infliximab in a rat model of intestinal ischemia/reperfusion injury. Toxicology and Industrial Health, 28(10), 923-32. https://doi.org/10.1177/0748233711427056
Pergel A, et al. Anti-inflammatory and Antioxidant Effects of Infliximab in a Rat Model of Intestinal Ischemia/reperfusion Injury. Toxicol Ind Health. 2012;28(10):923-32. PubMed PMID: 22082824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antioxidant effects of infliximab in a rat model of intestinal ischemia/reperfusion injury. AU - Pergel,Ahmet, AU - Kanter,Mehmet, AU - Yucel,Ahmet Fikret, AU - Aydin,Ibrahim, AU - Erboga,Mustafa, AU - Guzel,Ahmet, Y1 - 2011/11/14/ PY - 2011/11/16/entrez PY - 2011/11/16/pubmed PY - 2013/6/13/medline SP - 923 EP - 32 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 28 IS - 10 N2 - The aim of this study was to investigate the possible protective effects of infliximab on oxidative stress, cell proliferation and apoptosis in the rat intestinal mucosa after ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: sham, I/R and I/R+ infliximab; each group comprised 10 animals. Sham group animals underwent laparotomy without I/R injury. I/R groups after undergoing laparotomy, 1 hour of superior mesenteric artery ligation occurred, which was followed by 1 hour of reperfusion. In the infliximab group, 3 days before I/R, infliximab (3 mg/kg) was administered intravenously. All animals were killed at the end of reperfusion and intestinal tissues samples were obtained for biochemical and histopathological investigation in all groups. To date, no biochemical and histopathological changes have been reported regarding intestinal I/R injury in rats due to infliximab treatment. Infliximab treatment significantly decreased the elevated tissue malondialdehyde levels and increased reduced superoxide dismutase and glutathione peroxidase enzyme activities in intestinal tissues samples. I/R caused severe histopathological injury including mucosal erosions, inflammatory cell infiltration, necrosis, hemorrhage, and villous congestion. Infliximab treatment significantly attenuated the severity of intestinal I/R injury, inhibiting I/R-induced apoptosis, and cell proliferation. Because of its anti-inflammatory and antioxidant effects, infliximab pretreatment may have protective effects on the experimental intestinal I/R model of rats. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/22082824/Anti_inflammatory_and_antioxidant_effects_of_infliximab_in_a_rat_model_of_intestinal_ischemia/reperfusion_injury_ DB - PRIME DP - Unbound Medicine ER -