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Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring.
Epidemiology. 2012 Jan; 23(1):64-71.E

Abstract

BACKGROUND

Adequate vitamin D status in mothers during pregnancy may influence the health status of the child later in life. We assessed whether maternal circulating 25-hydroxyvitamin D (25[OH]D) concentrations in pregnancy are associated with risk of lower respiratory tract infections, wheezing, and asthma in the offspring.

METHODS

Data were obtained from 1724 children of the INfancia y Medio Ambiente (INMA) Project, a population-based birth cohort study. Maternal circulating 25(OH)D concentrations were measured in pregnancy (mean gestational age = 12.6 [SD = 2.5] weeks). When the child was age 1 year, parents were asked if their child had a physician-confirmed history of lower respiratory tract infections or a history of wheezing. The questions about wheezing were repeated annually thereafter. Asthma was defined as parental report of doctor diagnosis of asthma or receiving treatment at the age of 4-6 years or wheezing since the age of 4 years.

RESULTS

The median maternal circulating 25(OH)D concentration in pregnancy was 29.5 ng/mL (interquartile range, 22.5-37.1 ng/mL). After multivariable adjustment, there was a trend for an independent association between higher levels of maternal circulating 25(OH)D levels in pregnancy and decreased odds of lower respiratory tract infections in offspring (for cohort- and season-specific quartile Q4 vs. Q1, odds ratio = 0.67 [95% confidence interval = 0.50-0.90]; test for trend, P = 0.016). We found no association between 25(OH)D levels in pregnancy and risk of wheezing at age 1 year or 4 years, or asthma at age 4-6 years.

CONCLUSIONS

Higher maternal circulating 25(OH)D concentrations in pregnancy were independently associated with lower risk of lower respiratory tract infections in offspring in the first year of life but not with wheezing or asthma in childhood.

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Authors+Show Affiliations

Morales E
Center for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain. emorales1@creal.cat
Romieu I
No affiliation info available
Guerra S
No affiliation info available
Ballester F
No affiliation info available
Rebagliato M
No affiliation info available
Vioque J
No affiliation info available
Tardón A
No affiliation info available
Rodriguez Delhi C
No affiliation info available
Arranz L
No affiliation info available
Torrent M
No affiliation info available
Espada M
No affiliation info available
Basterrechea M
No affiliation info available
Sunyer J
No affiliation info available
INMA Project
No affiliation info available

MeSH

AsthmaChildChild, PreschoolCohort StudiesFemaleHumansPregnancyPregnancy ComplicationsRespiratory SoundsRespiratory Tract InfectionsSpainVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22082994

Citation

Morales, Eva, et al. "Maternal Vitamin D Status in Pregnancy and Risk of Lower Respiratory Tract Infections, Wheezing, and Asthma in Offspring." Epidemiology (Cambridge, Mass.), vol. 23, no. 1, 2012, pp. 64-71.
Morales E, Romieu I, Guerra S, et al. Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Epidemiology. 2012;23(1):64-71.
Morales, E., Romieu, I., Guerra, S., Ballester, F., Rebagliato, M., Vioque, J., Tardón, A., Rodriguez Delhi, C., Arranz, L., Torrent, M., Espada, M., Basterrechea, M., & Sunyer, J. (2012). Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Epidemiology (Cambridge, Mass.), 23(1), 64-71. https://doi.org/10.1097/EDE.0b013e31823a44d3
Morales E, et al. Maternal Vitamin D Status in Pregnancy and Risk of Lower Respiratory Tract Infections, Wheezing, and Asthma in Offspring. Epidemiology. 2012;23(1):64-71. PubMed PMID: 22082994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. AU - Morales,Eva, AU - Romieu,Isabelle, AU - Guerra,Stefano, AU - Ballester,Ferrán, AU - Rebagliato,Marisa, AU - Vioque,Jesús, AU - Tardón,Adonina, AU - Rodriguez Delhi,Cristina, AU - Arranz,Leonor, AU - Torrent,Maties, AU - Espada,Mercedes, AU - Basterrechea,Mikel, AU - Sunyer,Jordi, AU - ,, PY - 2011/11/16/entrez PY - 2011/11/16/pubmed PY - 2012/3/30/medline SP - 64 EP - 71 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 23 IS - 1 N2 - BACKGROUND: Adequate vitamin D status in mothers during pregnancy may influence the health status of the child later in life. We assessed whether maternal circulating 25-hydroxyvitamin D (25[OH]D) concentrations in pregnancy are associated with risk of lower respiratory tract infections, wheezing, and asthma in the offspring. METHODS: Data were obtained from 1724 children of the INfancia y Medio Ambiente (INMA) Project, a population-based birth cohort study. Maternal circulating 25(OH)D concentrations were measured in pregnancy (mean gestational age = 12.6 [SD = 2.5] weeks). When the child was age 1 year, parents were asked if their child had a physician-confirmed history of lower respiratory tract infections or a history of wheezing. The questions about wheezing were repeated annually thereafter. Asthma was defined as parental report of doctor diagnosis of asthma or receiving treatment at the age of 4-6 years or wheezing since the age of 4 years. RESULTS: The median maternal circulating 25(OH)D concentration in pregnancy was 29.5 ng/mL (interquartile range, 22.5-37.1 ng/mL). After multivariable adjustment, there was a trend for an independent association between higher levels of maternal circulating 25(OH)D levels in pregnancy and decreased odds of lower respiratory tract infections in offspring (for cohort- and season-specific quartile Q4 vs. Q1, odds ratio = 0.67 [95% confidence interval = 0.50-0.90]; test for trend, P = 0.016). We found no association between 25(OH)D levels in pregnancy and risk of wheezing at age 1 year or 4 years, or asthma at age 4-6 years. CONCLUSIONS: Higher maternal circulating 25(OH)D concentrations in pregnancy were independently associated with lower risk of lower respiratory tract infections in offspring in the first year of life but not with wheezing or asthma in childhood. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/22082994/Maternal_vitamin_D_status_in_pregnancy_and_risk_of_lower_respiratory_tract_infections_wheezing_and_asthma_in_offspring_ L2 - https://doi.org/10.1097/EDE.0b013e31823a44d3 DB - PRIME DP - Unbound Medicine ER -