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Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease.
Hypertension. 2012 Jan; 59(1):105-12.H

Abstract

Hypertension is very prevalent in chronic kidney disease and critical for its prognosis. Sympathoexcitation and oxidative stress have been demonstrated to be involved in chronic kidney disease. We have shown previously that sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in the salt-sensitive hypertension model, Dahl salt-sensitive rats. Thus, we investigated whether sympathoexcitation by excessive brain oxidative stress could contribute to arterial pressure elevation in salt-induced chronic kidney disease model rats. Young (3-week-old) male Sprague-Dawley rats were randomly assigned to a uninephrectomy or sham operation and then subjected to either a normal salt (0.5%) or high-salt (8.0%) diet for 4 weeks. The young salt-loaded uninephrectomized rats exhibited sympathoexcitation, hypertension, and renal injury, proteinuria and global glomerulosclerosis together with tubulointerstitial damage. Under urethane anesthesia and artificial ventilation, renal sympathetic nerve activity, arterial pressure, and heart rate decreased to a greater degree in the salt-loaded uninephrectomized rats than in the nonsalt-loaded uninephrectomized rats and the salt-loaded or nonsalt-loaded sham-operated rats, when Tempol, a membrane-permeable superoxide dismutase mimetic, was infused acutely into the lateral cerebral ventricle. Oxidative stress in the hypothalamus, measured by lucigenin chemiluminescence, was also significantly greater. Furthermore, in the salt-loaded uninephrectomized rats, antioxidant treatment with chronic intracerebroventricular Tempol decreased sympathetic nerve activity and arterial pressure, which, in turn, led to a decrease in renal damage. Similar effects were elicited by treatment with oral moxonidine, the central sympatholytic agent. In conclusion, sympathoexcitation by brain oxidative stress may mediate arterial pressure elevation in salt-induced chronic kidney disease.

Authors+Show Affiliations

Department of Nephrology and Endocrinology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. fujita-dis@h.u-tokyo.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22083162

Citation

Fujita, Megumi, et al. "Sympathoexcitation By Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-induced Chronic Kidney Disease." Hypertension (Dallas, Tex. : 1979), vol. 59, no. 1, 2012, pp. 105-12.
Fujita M, Ando K, Kawarazaki H, et al. Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease. Hypertension. 2012;59(1):105-12.
Fujita, M., Ando, K., Kawarazaki, H., Kawarasaki, C., Muraoka, K., Ohtsu, H., Shimizu, H., & Fujita, T. (2012). Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease. Hypertension (Dallas, Tex. : 1979), 59(1), 105-12. https://doi.org/10.1161/HYPERTENSIONAHA.111.182923
Fujita M, et al. Sympathoexcitation By Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-induced Chronic Kidney Disease. Hypertension. 2012;59(1):105-12. PubMed PMID: 22083162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease. AU - Fujita,Megumi, AU - Ando,Katsuyuki, AU - Kawarazaki,Hiroo, AU - Kawarasaki,Chiaki, AU - Muraoka,Kazuhiko, AU - Ohtsu,Hiroshi, AU - Shimizu,Hideki, AU - Fujita,Toshiro, Y1 - 2011/11/14/ PY - 2011/11/16/entrez PY - 2011/11/16/pubmed PY - 2012/2/9/medline SP - 105 EP - 12 JF - Hypertension (Dallas, Tex. : 1979) JO - Hypertension VL - 59 IS - 1 N2 - Hypertension is very prevalent in chronic kidney disease and critical for its prognosis. Sympathoexcitation and oxidative stress have been demonstrated to be involved in chronic kidney disease. We have shown previously that sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in the salt-sensitive hypertension model, Dahl salt-sensitive rats. Thus, we investigated whether sympathoexcitation by excessive brain oxidative stress could contribute to arterial pressure elevation in salt-induced chronic kidney disease model rats. Young (3-week-old) male Sprague-Dawley rats were randomly assigned to a uninephrectomy or sham operation and then subjected to either a normal salt (0.5%) or high-salt (8.0%) diet for 4 weeks. The young salt-loaded uninephrectomized rats exhibited sympathoexcitation, hypertension, and renal injury, proteinuria and global glomerulosclerosis together with tubulointerstitial damage. Under urethane anesthesia and artificial ventilation, renal sympathetic nerve activity, arterial pressure, and heart rate decreased to a greater degree in the salt-loaded uninephrectomized rats than in the nonsalt-loaded uninephrectomized rats and the salt-loaded or nonsalt-loaded sham-operated rats, when Tempol, a membrane-permeable superoxide dismutase mimetic, was infused acutely into the lateral cerebral ventricle. Oxidative stress in the hypothalamus, measured by lucigenin chemiluminescence, was also significantly greater. Furthermore, in the salt-loaded uninephrectomized rats, antioxidant treatment with chronic intracerebroventricular Tempol decreased sympathetic nerve activity and arterial pressure, which, in turn, led to a decrease in renal damage. Similar effects were elicited by treatment with oral moxonidine, the central sympatholytic agent. In conclusion, sympathoexcitation by brain oxidative stress may mediate arterial pressure elevation in salt-induced chronic kidney disease. SN - 1524-4563 UR - https://www.unboundmedicine.com/medline/citation/22083162/Sympathoexcitation_by_brain_oxidative_stress_mediates_arterial_pressure_elevation_in_salt_induced_chronic_kidney_disease_ L2 - http://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.111.182923?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -