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Effect of 12 months of whole-body vibration therapy on bone density and structure in postmenopausal women: a randomized trial.
Ann Intern Med. 2011 Nov 15; 155(10):668-79, W205.AIM

Abstract

BACKGROUND

Although data from studies in animals demonstrated beneficial effects of whole-body vibration (WBV) therapy on bone, clinical trials in postmenopausal women showed conflicting results.

OBJECTIVE

To determine whether WBV improves bone density and structure.

DESIGN

A 12-month, single-center, superiority, randomized, controlled trial with 3 parallel groups. (ClinicalTrials.gov registration number: NCT00420940)

SETTING

Toronto General Hospital, Ontario, Canada.

PARTICIPANTS

202 healthy postmenopausal women with bone mineral density (BMD) T-scores between -1.0 and -2.5 who were not receiving prescription bone medications.

INTERVENTION

Participants were randomly assigned to 1 of 3 groups (1:1:1 ratio) by using a block-randomization scheme and sealed envelopes. They were asked to stand on a low-magnitude (0.3g) 90-Hz or 30-Hz WBV platform for 20 minutes daily or to serve as control participants; all participants received calcium and vitamin D.

MEASUREMENTS

Bone outcome assessors, who were blinded to group assignment, determined trabecular volumetric BMD and other measurements of the distal tibia and distal radius with high-resolution peripheral quantitative computed tomography and areal BMD with dual-energy x-ray absorptiometry at baseline and at 12 months.

RESULTS

12 months of WBV therapy had no significant effect on any bone outcomes compared with no WBV therapy. For the primary outcome of tibial trabecular volumetric BMD, mean change from baseline was 0.4 mg/cm(3) (95% CI, -0.4 to 1.2 mg/cm(3)) in the 90-Hz WBV group, -0.1 mg/cm(3) (CI, -1.0 to 0.8 mg/cm(3)) in the 30-Hz WBV group, and -0.2 mg/cm(3) (CI, -1.1 to 0.6 mg/cm(3)) in the control group (P = 0.55). Changes in areal BMD at the femoral neck, total hip, and lumbar spine were also similar among the groups. Overall, low-magnitude WBV at both 90 and 30 Hz was well-tolerated.

LIMITATIONS

Adherence to WBV ranged from 65% to 79%. Double-blinding was not possible.

CONCLUSION

Whole-body vibration therapy at 0.3g and 90 or 30 Hz for 12 months did not alter BMD or bone structure in postmenopausal women who received calcium and vitamin D supplementation.

Links

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Authors+Show Affiliations

Slatkovska L
University Health Network, Mount Sinai Hospital, and University of Toronto, Toronto, and McMaster University, Hamilton, Ontario, Canada.
Alibhai SM
No affiliation info available
Beyene J
No affiliation info available
Hu H
No affiliation info available
Demaras A
No affiliation info available
Cheung AM
No affiliation info available

MeSH

Absorptiometry, PhotonAdultAgedBone DensityCalcium, DietaryDietary SupplementsFemaleFollow-Up StudiesHipHumansMiddle AgedOsteoporosis, PostmenopausalPatient CompliancePostmenopauseRadiusSpineTibiaVibrationVitamin D

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22084333

Clinical Trial Links

Clinical trial which this article describes

Citation

Slatkovska, Lubomira, et al. "Effect of 12 Months of Whole-body Vibration Therapy On Bone Density and Structure in Postmenopausal Women: a Randomized Trial." Annals of Internal Medicine, vol. 155, no. 10, 2011, pp. 668-79, W205.
Slatkovska L, Alibhai SM, Beyene J, et al. Effect of 12 months of whole-body vibration therapy on bone density and structure in postmenopausal women: a randomized trial. Ann Intern Med. 2011;155(10):668-79, W205.
Slatkovska, L., Alibhai, S. M., Beyene, J., Hu, H., Demaras, A., & Cheung, A. M. (2011). Effect of 12 months of whole-body vibration therapy on bone density and structure in postmenopausal women: a randomized trial. Annals of Internal Medicine, 155(10), 668-79, W205. https://doi.org/10.7326/0003-4819-155-10-201111150-00005
Slatkovska L, et al. Effect of 12 Months of Whole-body Vibration Therapy On Bone Density and Structure in Postmenopausal Women: a Randomized Trial. Ann Intern Med. 2011 Nov 15;155(10):668-79, W205. PubMed PMID: 22084333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 12 months of whole-body vibration therapy on bone density and structure in postmenopausal women: a randomized trial. AU - Slatkovska,Lubomira, AU - Alibhai,Shabbir M H, AU - Beyene,Joseph, AU - Hu,Hanxian, AU - Demaras,Alice, AU - Cheung,Angela M, PY - 2011/11/16/entrez PY - 2011/11/16/pubmed PY - 2012/3/1/medline SP - 668-79, W205 JF - Annals of internal medicine JO - Ann Intern Med VL - 155 IS - 10 N2 - BACKGROUND: Although data from studies in animals demonstrated beneficial effects of whole-body vibration (WBV) therapy on bone, clinical trials in postmenopausal women showed conflicting results. OBJECTIVE: To determine whether WBV improves bone density and structure. DESIGN: A 12-month, single-center, superiority, randomized, controlled trial with 3 parallel groups. (ClinicalTrials.gov registration number: NCT00420940) SETTING: Toronto General Hospital, Ontario, Canada. PARTICIPANTS: 202 healthy postmenopausal women with bone mineral density (BMD) T-scores between -1.0 and -2.5 who were not receiving prescription bone medications. INTERVENTION: Participants were randomly assigned to 1 of 3 groups (1:1:1 ratio) by using a block-randomization scheme and sealed envelopes. They were asked to stand on a low-magnitude (0.3g) 90-Hz or 30-Hz WBV platform for 20 minutes daily or to serve as control participants; all participants received calcium and vitamin D. MEASUREMENTS: Bone outcome assessors, who were blinded to group assignment, determined trabecular volumetric BMD and other measurements of the distal tibia and distal radius with high-resolution peripheral quantitative computed tomography and areal BMD with dual-energy x-ray absorptiometry at baseline and at 12 months. RESULTS: 12 months of WBV therapy had no significant effect on any bone outcomes compared with no WBV therapy. For the primary outcome of tibial trabecular volumetric BMD, mean change from baseline was 0.4 mg/cm(3) (95% CI, -0.4 to 1.2 mg/cm(3)) in the 90-Hz WBV group, -0.1 mg/cm(3) (CI, -1.0 to 0.8 mg/cm(3)) in the 30-Hz WBV group, and -0.2 mg/cm(3) (CI, -1.1 to 0.6 mg/cm(3)) in the control group (P = 0.55). Changes in areal BMD at the femoral neck, total hip, and lumbar spine were also similar among the groups. Overall, low-magnitude WBV at both 90 and 30 Hz was well-tolerated. LIMITATIONS: Adherence to WBV ranged from 65% to 79%. Double-blinding was not possible. CONCLUSION: Whole-body vibration therapy at 0.3g and 90 or 30 Hz for 12 months did not alter BMD or bone structure in postmenopausal women who received calcium and vitamin D supplementation. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/22084333/Effect_of_12_months_of_whole_body_vibration_therapy_on_bone_density_and_structure_in_postmenopausal_women:_a_randomized_trial_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-155-10-201111150-00005?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -