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Prophylactic use of antimalarials during pregnancy.
Can Fam Physician. 2011 Nov; 57(11):1279-81.CF

Abstract

QUESTION

Some of my pregnant patients wish to travel to malaria-endemic regions. Are there medications that can be used safely during pregnancy for malaria prophylaxis?

ANSWER

Pregnant women should avoid travel to malaria-endemic areas if possible. However, if travel cannot be avoided, measures to prevent mosquito bites, along with an effective chemoprophylaxis regimen, should be implemented. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Although the atovaquone-proguanil drug combination is not currently recommended for use during pregnancy, limited data suggest that it is not harmful to the fetus. Doxycycline and primaquine are not recommended during pregnancy.

Authors+Show Affiliations

Faculty of Pharmacy, University of Toronto, Ont.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22084457

Citation

Irvine, Marie-Hélène, et al. "Prophylactic Use of Antimalarials During Pregnancy." Canadian Family Physician Medecin De Famille Canadien, vol. 57, no. 11, 2011, pp. 1279-81.
Irvine MH, Einarson A, Bozzo P. Prophylactic use of antimalarials during pregnancy. Can Fam Physician. 2011;57(11):1279-81.
Irvine, M. H., Einarson, A., & Bozzo, P. (2011). Prophylactic use of antimalarials during pregnancy. Canadian Family Physician Medecin De Famille Canadien, 57(11), 1279-81.
Irvine MH, Einarson A, Bozzo P. Prophylactic Use of Antimalarials During Pregnancy. Can Fam Physician. 2011;57(11):1279-81. PubMed PMID: 22084457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylactic use of antimalarials during pregnancy. AU - Irvine,Marie-Hélène, AU - Einarson,Adrienne, AU - Bozzo,Pina, PY - 2011/11/16/entrez PY - 2011/11/16/pubmed PY - 2012/4/11/medline SP - 1279 EP - 81 JF - Canadian family physician Medecin de famille canadien JO - Can Fam Physician VL - 57 IS - 11 N2 - QUESTION: Some of my pregnant patients wish to travel to malaria-endemic regions. Are there medications that can be used safely during pregnancy for malaria prophylaxis? ANSWER: Pregnant women should avoid travel to malaria-endemic areas if possible. However, if travel cannot be avoided, measures to prevent mosquito bites, along with an effective chemoprophylaxis regimen, should be implemented. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Although the atovaquone-proguanil drug combination is not currently recommended for use during pregnancy, limited data suggest that it is not harmful to the fetus. Doxycycline and primaquine are not recommended during pregnancy. SN - 1715-5258 UR - https://www.unboundmedicine.com/medline/citation/22084457/full_citation L2 - http://www.cfp.ca/cgi/pmidlookup?view=long&pmid=22084457 DB - PRIME DP - Unbound Medicine ER -