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Evaluation and use of NS1 IgM antibody detection for acute dengue virus diagnosis: report from an outbreak investigation.
Clin Microbiol Infect. 2012 Jan; 18(1):E8-10.CM

Abstract

The usefulness of detecting circulating non-structural protein 1 (NS1) IgM antibodies for diagnosing acute dengue virus infection was evaluated during an outbreak investigation along with other routinely used laboratory diagnostic methods. For the first time, the samples were also tested for NS1 antigen detection. NS1 IgM antibody detects all the serum samples that were positive for NS1 antigen detection within first 5 days of infection. The sensitivity of the NS1 IgM ELISA was higher when compared with RT-PCR and therefore, it could be used for early diagnosis.

Authors+Show Affiliations

Department of Biotechnology, Anna University of Technology, Tiruchirappalli, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22084954

Citation

Gowri Sankar, S, et al. "Evaluation and Use of NS1 IgM Antibody Detection for Acute Dengue Virus Diagnosis: Report From an Outbreak Investigation." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 18, no. 1, 2012, pp. E8-10.
Gowri Sankar S, Dhananjeyan KJ, Paramasivan R, et al. Evaluation and use of NS1 IgM antibody detection for acute dengue virus diagnosis: report from an outbreak investigation. Clin Microbiol Infect. 2012;18(1):E8-10.
Gowri Sankar, S., Dhananjeyan, K. J., Paramasivan, R., Thenmozhi, V., Tyagi, B. K., & John Vennison, S. (2012). Evaluation and use of NS1 IgM antibody detection for acute dengue virus diagnosis: report from an outbreak investigation. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(1), E8-10. https://doi.org/10.1111/j.1469-0691.2011.03694.x
Gowri Sankar S, et al. Evaluation and Use of NS1 IgM Antibody Detection for Acute Dengue Virus Diagnosis: Report From an Outbreak Investigation. Clin Microbiol Infect. 2012;18(1):E8-10. PubMed PMID: 22084954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation and use of NS1 IgM antibody detection for acute dengue virus diagnosis: report from an outbreak investigation. AU - Gowri Sankar,S, AU - Dhananjeyan,K J, AU - Paramasivan,R, AU - Thenmozhi,V, AU - Tyagi,B K, AU - John Vennison,S, Y1 - 2011/11/15/ PY - 2011/11/17/entrez PY - 2011/11/17/pubmed PY - 2012/6/14/medline SP - E8 EP - 10 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 18 IS - 1 N2 - The usefulness of detecting circulating non-structural protein 1 (NS1) IgM antibodies for diagnosing acute dengue virus infection was evaluated during an outbreak investigation along with other routinely used laboratory diagnostic methods. For the first time, the samples were also tested for NS1 antigen detection. NS1 IgM antibody detects all the serum samples that were positive for NS1 antigen detection within first 5 days of infection. The sensitivity of the NS1 IgM ELISA was higher when compared with RT-PCR and therefore, it could be used for early diagnosis. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/22084954/Evaluation_and_use_of_NS1_IgM_antibody_detection_for_acute_dengue_virus_diagnosis:_report_from_an_outbreak_investigation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)62714-2 DB - PRIME DP - Unbound Medicine ER -