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Foam granulation: new developments in pharmaceutical solid oral dosage forms using twin screw extrusion machinery.
Drug Dev Ind Pharm. 2012 Jul; 38(7):771-84.DD

Abstract

This paper investigates foam granulation in a twin screw extruder as a new continuous wet granulation technique for pharmaceutical powder drug formulations. Foamed aqueous binder has a reportedly lower soak-to-spread ratio than drop or spray liquid addition in batch granulation. This work demonstrates a twin screw extruder configuration for foam granulation and subsequently compares the new approach against liquid injection in the granulation of α-lactose monohydrate with a methylcellulose binder. Trials were conducted at high powder output rates (20-40 kg/h) and high screw speeds (220-320 RPM) with two screw configurations. Process stability improved with the new technique allowing granulation with less binder. The extruded mass maintained a low exit temperature, being insensitive to operating conditions unlike the liquid injection approach, where temperatures rose significantly as flow rate increased. The particle size distribution by foam granulation reflected a more uniformly wetted mass with larger granule growth noted even for conditions where dry powder exited by liquid injection. Other factors were found similar between the two binder delivery methods such as consumed mechanical energy, as well as fracture strength and compressibility of produced granules.

Authors+Show Affiliations

MMRI/ CAPPA-D, Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada. mthomps@mcmaster.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22085462

Citation

Thompson, M R., et al. "Foam Granulation: New Developments in Pharmaceutical Solid Oral Dosage Forms Using Twin Screw Extrusion Machinery." Drug Development and Industrial Pharmacy, vol. 38, no. 7, 2012, pp. 771-84.
Thompson MR, Weatherley S, Pukadyil RN, et al. Foam granulation: new developments in pharmaceutical solid oral dosage forms using twin screw extrusion machinery. Drug Dev Ind Pharm. 2012;38(7):771-84.
Thompson, M. R., Weatherley, S., Pukadyil, R. N., & Sheskey, P. J. (2012). Foam granulation: new developments in pharmaceutical solid oral dosage forms using twin screw extrusion machinery. Drug Development and Industrial Pharmacy, 38(7), 771-84. https://doi.org/10.3109/03639045.2011.633265
Thompson MR, et al. Foam Granulation: New Developments in Pharmaceutical Solid Oral Dosage Forms Using Twin Screw Extrusion Machinery. Drug Dev Ind Pharm. 2012;38(7):771-84. PubMed PMID: 22085462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Foam granulation: new developments in pharmaceutical solid oral dosage forms using twin screw extrusion machinery. AU - Thompson,M R, AU - Weatherley,S, AU - Pukadyil,R N, AU - Sheskey,P J, Y1 - 2011/11/15/ PY - 2011/11/17/entrez PY - 2011/11/17/pubmed PY - 2015/5/30/medline SP - 771 EP - 84 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 38 IS - 7 N2 - This paper investigates foam granulation in a twin screw extruder as a new continuous wet granulation technique for pharmaceutical powder drug formulations. Foamed aqueous binder has a reportedly lower soak-to-spread ratio than drop or spray liquid addition in batch granulation. This work demonstrates a twin screw extruder configuration for foam granulation and subsequently compares the new approach against liquid injection in the granulation of α-lactose monohydrate with a methylcellulose binder. Trials were conducted at high powder output rates (20-40 kg/h) and high screw speeds (220-320 RPM) with two screw configurations. Process stability improved with the new technique allowing granulation with less binder. The extruded mass maintained a low exit temperature, being insensitive to operating conditions unlike the liquid injection approach, where temperatures rose significantly as flow rate increased. The particle size distribution by foam granulation reflected a more uniformly wetted mass with larger granule growth noted even for conditions where dry powder exited by liquid injection. Other factors were found similar between the two binder delivery methods such as consumed mechanical energy, as well as fracture strength and compressibility of produced granules. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/22085462/Foam_granulation:_new_developments_in_pharmaceutical_solid_oral_dosage_forms_using_twin_screw_extrusion_machinery_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2011.633265 DB - PRIME DP - Unbound Medicine ER -