Tags

Type your tag names separated by a space and hit enter

White matter microstructure in untreated first episode bipolar disorder with psychosis: comparison with schizophrenia.
Bipolar Disord. 2011 Nov-Dec; 13(7-8):604-13.BD

Abstract

OBJECTIVES

White matter abnormalities have been reported in bipolar disorder. The present study aimed to investigate white matter integrity in untreated first episode patients with psychotic bipolar disorder using diffusion tensor imaging, and to compare observations with those from untreated first episode schizophrenia patients.

METHODS

Fractional anisotropy and mean diffusivity were measured in first episode psychotic patients with bipolar disorder (n = 13) or schizophrenia (n = 21) and healthy individuals (n = 18). Group differences were evaluated using voxel-based morphometry. Axial and radial diffusivity were examined in regions with altered fractional anisotropy in post-hoc analyses.

RESULTS

Patients with bipolar disorder showed lower fractional anisotropy than healthy controls in several white matter tracts. Compared with schizophrenia patients, bipolar disorder patients showed lower fractional anisotropy in the cingulum, internal capsule, posterior corpus callosum, tapetum, and occipital white matter including posterior thalamic radiation and inferior longitudinal fasciculus/inferior fronto-occipital fasciculus. Lower fractional anisotropy in bipolar disorder was characterized by increased radial diffusion rather than axial diffusion along the orientation of fiber tracts. Across several white matter tracts, both patient groups showed greater mean diffusivity than healthy individuals.

CONCLUSIONS

Selectively increased radial diffusivity in bipolar disorder patients suggests structural disorganization in fiber tract coherence of neurodevelopmental origin or alterations in myelin sheaths along fiber tracts. In contrast, increased isotropic diffusion along white matter tracts in schizophrenia patients with alterations in both radial and axial diffusivity suggests increased water content outside the axonal space. Thus, the present results suggest that different pathophysiological mechanisms may underlie white matter microstructural abnormalities in bipolar disorder and schizophrenia.

Authors+Show Affiliations

Department of Psychology, Roosevelt University, Chicago, IL 60605, USA. llu@roosevelt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22085473

Citation

Lu, Lisa H., et al. "White Matter Microstructure in Untreated First Episode Bipolar Disorder With Psychosis: Comparison With Schizophrenia." Bipolar Disorders, vol. 13, no. 7-8, 2011, pp. 604-13.
Lu LH, Zhou XJ, Keedy SK, et al. White matter microstructure in untreated first episode bipolar disorder with psychosis: comparison with schizophrenia. Bipolar Disord. 2011;13(7-8):604-13.
Lu, L. H., Zhou, X. J., Keedy, S. K., Reilly, J. L., & Sweeney, J. A. (2011). White matter microstructure in untreated first episode bipolar disorder with psychosis: comparison with schizophrenia. Bipolar Disorders, 13(7-8), 604-13. https://doi.org/10.1111/j.1399-5618.2011.00958.x
Lu LH, et al. White Matter Microstructure in Untreated First Episode Bipolar Disorder With Psychosis: Comparison With Schizophrenia. Bipolar Disord. 2011 Nov-Dec;13(7-8):604-13. PubMed PMID: 22085473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White matter microstructure in untreated first episode bipolar disorder with psychosis: comparison with schizophrenia. AU - Lu,Lisa H, AU - Zhou,Xiaohong Joe, AU - Keedy,Sarah K, AU - Reilly,James L, AU - Sweeney,John A, PY - 2011/11/17/entrez PY - 2011/11/17/pubmed PY - 2012/3/21/medline SP - 604 EP - 13 JF - Bipolar disorders JO - Bipolar Disord VL - 13 IS - 7-8 N2 - OBJECTIVES: White matter abnormalities have been reported in bipolar disorder. The present study aimed to investigate white matter integrity in untreated first episode patients with psychotic bipolar disorder using diffusion tensor imaging, and to compare observations with those from untreated first episode schizophrenia patients. METHODS: Fractional anisotropy and mean diffusivity were measured in first episode psychotic patients with bipolar disorder (n = 13) or schizophrenia (n = 21) and healthy individuals (n = 18). Group differences were evaluated using voxel-based morphometry. Axial and radial diffusivity were examined in regions with altered fractional anisotropy in post-hoc analyses. RESULTS: Patients with bipolar disorder showed lower fractional anisotropy than healthy controls in several white matter tracts. Compared with schizophrenia patients, bipolar disorder patients showed lower fractional anisotropy in the cingulum, internal capsule, posterior corpus callosum, tapetum, and occipital white matter including posterior thalamic radiation and inferior longitudinal fasciculus/inferior fronto-occipital fasciculus. Lower fractional anisotropy in bipolar disorder was characterized by increased radial diffusion rather than axial diffusion along the orientation of fiber tracts. Across several white matter tracts, both patient groups showed greater mean diffusivity than healthy individuals. CONCLUSIONS: Selectively increased radial diffusivity in bipolar disorder patients suggests structural disorganization in fiber tract coherence of neurodevelopmental origin or alterations in myelin sheaths along fiber tracts. In contrast, increased isotropic diffusion along white matter tracts in schizophrenia patients with alterations in both radial and axial diffusivity suggests increased water content outside the axonal space. Thus, the present results suggest that different pathophysiological mechanisms may underlie white matter microstructural abnormalities in bipolar disorder and schizophrenia. SN - 1399-5618 UR - https://www.unboundmedicine.com/medline/citation/22085473/White_matter_microstructure_in_untreated_first_episode_bipolar_disorder_with_psychosis:_comparison_with_schizophrenia_ L2 - https://doi.org/10.1111/j.1399-5618.2011.00958.x DB - PRIME DP - Unbound Medicine ER -