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Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome.
Int J Mol Med. 2012 Feb; 29(2):311-8.IJ

Abstract

The present study aims at exploring the effects of sardine protein on insulin resistance, plasma lipid profile, as well as oxidative and inflammatory status in rats with fructose-induced metabolic syndrome. Rats were fed sardine protein (S) or casein (C) diets supplemented or not with high-fructose (HF) for 2 months. Rats fed the HF diets had greater body weight and adiposity and lower food intake as compared to control rats. Increased plasma glucose, insulin, HbA1C, triacylglycerols, free fatty acids and impaired glucose tolerance and insulin resistance was observed in HF-fed rats. Moreover, a decline in adipose tissues antioxidant status and a rise in lipid peroxidation and plasma TNF-α and fibrinogen were noted. Rats fed sardine protein diets exhibited lower food intake and fat mass than those fed casein diets. Sardine protein diets diminished plasma insulin and insulin resistance. Plasma triacylglycerol and free fatty acids were also lower, while those of α-tocopherol, taurine and calcium were enhanced as compared to casein diets. Moreover, S-HF diet significantly decreased plasma glucose and HbA1C. Sardine protein consumption lowered hydroperoxide levels in perirenal and brown adipose tissues. The S-HF diet, as compared to C-HF diet decreased epididymal hydroperoxides. Feeding sardine protein diets decreased brown adipose tissue carbonyls and increased glutathione peroxidase activity. Perirenal and epididymal superoxide dismutase and catalase activities and brown catalase activity were significantly greater in S-HF group than in C-HF group. Sardine protein diets also prevented hyperleptinemia and reduced inflammatory status in comparison with rats fed casein diets. Taken together, these results support the beneficial effect of sardine protein in fructose-induced metabolic syndrome on such variables as hyperglycemia, insulin resistance, hyperlipidemia and oxidative and inflammatory status, suggesting the possible use of sardine protein as a protective strategy against insulin resistance and related situations.

Authors+Show Affiliations

Department of Biology, Es-Sénia University, Oran, Algeria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22085913

Citation

Madani, Zohra, et al. "Dietary Sardine Protein Lowers Insulin Resistance, Leptin and TNF-α and Beneficially Affects Adipose Tissue Oxidative Stress in Rats With Fructose-induced Metabolic Syndrome." International Journal of Molecular Medicine, vol. 29, no. 2, 2012, pp. 311-8.
Madani Z, Louchami K, Sener A, et al. Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome. Int J Mol Med. 2012;29(2):311-8.
Madani, Z., Louchami, K., Sener, A., Malaisse, W. J., & Ait Yahia, D. (2012). Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome. International Journal of Molecular Medicine, 29(2), 311-8. https://doi.org/10.3892/ijmm.2011.836
Madani Z, et al. Dietary Sardine Protein Lowers Insulin Resistance, Leptin and TNF-α and Beneficially Affects Adipose Tissue Oxidative Stress in Rats With Fructose-induced Metabolic Syndrome. Int J Mol Med. 2012;29(2):311-8. PubMed PMID: 22085913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome. AU - Madani,Zohra, AU - Louchami,Karim, AU - Sener,Abdullah, AU - Malaisse,Willy J, AU - Ait Yahia,Dalila, Y1 - 2011/11/11/ PY - 2011/08/15/received PY - 2011/10/25/accepted PY - 2011/11/17/entrez PY - 2011/11/17/pubmed PY - 2012/4/14/medline SP - 311 EP - 8 JF - International journal of molecular medicine JO - Int. J. Mol. Med. VL - 29 IS - 2 N2 - The present study aims at exploring the effects of sardine protein on insulin resistance, plasma lipid profile, as well as oxidative and inflammatory status in rats with fructose-induced metabolic syndrome. Rats were fed sardine protein (S) or casein (C) diets supplemented or not with high-fructose (HF) for 2 months. Rats fed the HF diets had greater body weight and adiposity and lower food intake as compared to control rats. Increased plasma glucose, insulin, HbA1C, triacylglycerols, free fatty acids and impaired glucose tolerance and insulin resistance was observed in HF-fed rats. Moreover, a decline in adipose tissues antioxidant status and a rise in lipid peroxidation and plasma TNF-α and fibrinogen were noted. Rats fed sardine protein diets exhibited lower food intake and fat mass than those fed casein diets. Sardine protein diets diminished plasma insulin and insulin resistance. Plasma triacylglycerol and free fatty acids were also lower, while those of α-tocopherol, taurine and calcium were enhanced as compared to casein diets. Moreover, S-HF diet significantly decreased plasma glucose and HbA1C. Sardine protein consumption lowered hydroperoxide levels in perirenal and brown adipose tissues. The S-HF diet, as compared to C-HF diet decreased epididymal hydroperoxides. Feeding sardine protein diets decreased brown adipose tissue carbonyls and increased glutathione peroxidase activity. Perirenal and epididymal superoxide dismutase and catalase activities and brown catalase activity were significantly greater in S-HF group than in C-HF group. Sardine protein diets also prevented hyperleptinemia and reduced inflammatory status in comparison with rats fed casein diets. Taken together, these results support the beneficial effect of sardine protein in fructose-induced metabolic syndrome on such variables as hyperglycemia, insulin resistance, hyperlipidemia and oxidative and inflammatory status, suggesting the possible use of sardine protein as a protective strategy against insulin resistance and related situations. SN - 1791-244X UR - https://www.unboundmedicine.com/medline/citation/22085913/Dietary_sardine_protein_lowers_insulin_resistance_leptin_and_TNF_α_and_beneficially_affects_adipose_tissue_oxidative_stress_in_rats_with_fructose_induced_metabolic_syndrome_ L2 - http://www.spandidos-publications.com/ijmm/29/2/311 DB - PRIME DP - Unbound Medicine ER -