Tags

Type your tag names separated by a space and hit enter

Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial.
Int J Food Sci Nutr. 2012 Jun; 63(4):476-82.IJ

Abstract

This randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a dietary supplement (tablet form) providing 1.8 g/day free (non-esterified) plant sterols and stanols versus placebo for 6 weeks as part of a therapeutic lifestyle changes (TLC) diet in 32 men and women with primary hypercholesterolaemia. Mean ± SE baseline (end of a 5-week TLC diet lead-in) lipid concentrations (mmol/l) were total cholesterol (TC), 5.88 ± 0.08; non-high-density lipoprotein cholesterol (non-HDL-C), 4.71 ± 0.09; low-density lipoprotein cholesterol (LDL-C), 4.02 ± 0.08; HDL-C, 1.17 ± 0.06 and triglycerides (TGs), 1.51 ± 0.12. Differences from control in responses (plant sterol/stanol - control) were significant (p < 0.05) for LDL-C (- 4.9%), non-HDL-C (- 3.6%) and TC (- 2.8%). HDL-C and TG responses were not significantly different between treatment conditions. These results indicate that 1.8 g/day free plant sterols/stanols administered in a tablet produced favourable lipoprotein lipid changes in men and women with hypercholesterolaemia.

Authors+Show Affiliations

Provident Clinical Research/Biofortis North America, 489 Taft Avenue, Glen Ellyn, IL 60137, USA. kmaki@providentcrc.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22087585

Citation

Maki, Kevin C., et al. "Lipid-altering Effects of a Dietary Supplement Tablet Containing Free Plant Sterols and Stanols in Men and Women With Primary Hypercholesterolaemia: a Randomized, Placebo-controlled Crossover Trial." International Journal of Food Sciences and Nutrition, vol. 63, no. 4, 2012, pp. 476-82.
Maki KC, Lawless AL, Reeves MS, et al. Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial. Int J Food Sci Nutr. 2012;63(4):476-82.
Maki, K. C., Lawless, A. L., Reeves, M. S., Dicklin, M. R., Jenks, B. H., Shneyvas, E., & Brooks, J. R. (2012). Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial. International Journal of Food Sciences and Nutrition, 63(4), 476-82. https://doi.org/10.3109/09637486.2011.636345
Maki KC, et al. Lipid-altering Effects of a Dietary Supplement Tablet Containing Free Plant Sterols and Stanols in Men and Women With Primary Hypercholesterolaemia: a Randomized, Placebo-controlled Crossover Trial. Int J Food Sci Nutr. 2012;63(4):476-82. PubMed PMID: 22087585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial. AU - Maki,Kevin C, AU - Lawless,Andrea L, AU - Reeves,Matthew S, AU - Dicklin,Mary R, AU - Jenks,Belinda H, AU - Shneyvas,Ed, AU - Brooks,James R, Y1 - 2011/11/17/ PY - 2011/11/18/entrez PY - 2011/11/18/pubmed PY - 2012/9/5/medline SP - 476 EP - 82 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 63 IS - 4 N2 - This randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a dietary supplement (tablet form) providing 1.8 g/day free (non-esterified) plant sterols and stanols versus placebo for 6 weeks as part of a therapeutic lifestyle changes (TLC) diet in 32 men and women with primary hypercholesterolaemia. Mean ± SE baseline (end of a 5-week TLC diet lead-in) lipid concentrations (mmol/l) were total cholesterol (TC), 5.88 ± 0.08; non-high-density lipoprotein cholesterol (non-HDL-C), 4.71 ± 0.09; low-density lipoprotein cholesterol (LDL-C), 4.02 ± 0.08; HDL-C, 1.17 ± 0.06 and triglycerides (TGs), 1.51 ± 0.12. Differences from control in responses (plant sterol/stanol - control) were significant (p < 0.05) for LDL-C (- 4.9%), non-HDL-C (- 3.6%) and TC (- 2.8%). HDL-C and TG responses were not significantly different between treatment conditions. These results indicate that 1.8 g/day free plant sterols/stanols administered in a tablet produced favourable lipoprotein lipid changes in men and women with hypercholesterolaemia. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/22087585/Lipid_altering_effects_of_a_dietary_supplement_tablet_containing_free_plant_sterols_and_stanols_in_men_and_women_with_primary_hypercholesterolaemia:_a_randomized_placebo_controlled_crossover_trial_ L2 - https://www.tandfonline.com/doi/full/10.3109/09637486.2011.636345 DB - PRIME DP - Unbound Medicine ER -