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Proteomic tools against the neglected pathology of snake bite envenoming.
Expert Rev Proteomics. 2011 Dec; 8(6):739-58.ER

Abstract

This article covers the application of proteomic tools ('venomics', 'antivenomics' and 'venom phenotyping') to study the composition and natural history of snake venoms, and the cross-reactivity of antivenoms with homologous and heterologous venoms, to help address the neglected pathology of snake bite envenoming. The identification of evolutionary and immunological trends may help to replace the traditional geographic- and phylogenetic-driven hypotheses for antivenom production strategies with a more rational approach based on proteome phenotype and immunological profile similarities. Antivenomics and venom phenotyping may also contribute to expand the clinical range of currently existing antidotes.

Authors+Show Affiliations

Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Jaime Roig 11, 46010 Valencia, Spain. jcalvete@ibv.csic.es

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22087658

Citation

Calvete, Juan J.. "Proteomic Tools Against the Neglected Pathology of Snake Bite Envenoming." Expert Review of Proteomics, vol. 8, no. 6, 2011, pp. 739-58.
Calvete JJ. Proteomic tools against the neglected pathology of snake bite envenoming. Expert Rev Proteomics. 2011;8(6):739-58.
Calvete, J. J. (2011). Proteomic tools against the neglected pathology of snake bite envenoming. Expert Review of Proteomics, 8(6), 739-58. https://doi.org/10.1586/epr.11.61
Calvete JJ. Proteomic Tools Against the Neglected Pathology of Snake Bite Envenoming. Expert Rev Proteomics. 2011;8(6):739-58. PubMed PMID: 22087658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proteomic tools against the neglected pathology of snake bite envenoming. A1 - Calvete,Juan J, PY - 2011/11/18/entrez PY - 2011/11/18/pubmed PY - 2012/3/22/medline SP - 739 EP - 58 JF - Expert review of proteomics JO - Expert Rev Proteomics VL - 8 IS - 6 N2 - This article covers the application of proteomic tools ('venomics', 'antivenomics' and 'venom phenotyping') to study the composition and natural history of snake venoms, and the cross-reactivity of antivenoms with homologous and heterologous venoms, to help address the neglected pathology of snake bite envenoming. The identification of evolutionary and immunological trends may help to replace the traditional geographic- and phylogenetic-driven hypotheses for antivenom production strategies with a more rational approach based on proteome phenotype and immunological profile similarities. Antivenomics and venom phenotyping may also contribute to expand the clinical range of currently existing antidotes. SN - 1744-8387 UR - https://www.unboundmedicine.com/medline/citation/22087658/Proteomic_tools_against_the_neglected_pathology_of_snake_bite_envenoming_ L2 - https://www.tandfonline.com/doi/full/10.1586/epr.11.61 DB - PRIME DP - Unbound Medicine ER -
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