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Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug.
Drug Dev Ind Pharm. 2012 Jul; 38(7):883-92.DD

Abstract

The main purpose of this work is to formulate self-microemulsifying drug delivery system (SMEDDS) using smaller molecular oil with Atorvastatin calcium as a model drug. Solubility of the selected drug was accessed in oils and surfactants. Percent transmittance (%T) test study was performed to identify the efficient self-microemulsifying formulations. Those formulations which showed higher value for %T were evaluated for droplet size, polydispersity index, ζ potential, refractive index and cloud point measurement. Effect of drug loading on droplet size, increasing dilution in different media, thermodynamic stability and in vitro dissolution was performed to observe the performance of the selected formulation. Further cytotoxicity and permeation enhancement studies were carried out on Caco2 cell lines. Of all the oils accessed for drug solubility, Capmul MCM showed higher solubility capacity for Atorvastatin calcium. Capmul MCM was better microemulsified using combination of Tween 20 and Labrasol surfactant. Droplet size was as low as 86.93 nm with polydispersity index and ζ potential at 0.195 ± 0.011 and -7.27 ± 3.11 mV respectively. The selected undiluted formulation showed refractive index values ranging from 1.40 to 1.47 indicating the isotropicity of the formulation. The selected formulation was robust to dilution in different media and thermodynamically stable. Dissolution profile was enhanced for the selected drug as compared to marketed formulation with t85% and DE values at 10 min and 80.15 respectively. Also cytotoxicity measurement showed minimum effect with good permeation enhancing capacity. Thus our study demonstrates the use of smaller molecular oil (Capmul MCM) for developing self-microemulsifying drug delivery system for better in vitro and in vivo performance.

Authors+Show Affiliations

Department of Pharmaceutics, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune, Maharashtra, India. mithunband@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22087760

Citation

Bandivadeka, Mithun Mohanraor, et al. "Self-microemulsifying Smaller Molecular Volume Oil (Capmul MCM) Using Non-ionic Surfactants: a Delivery System for Poorly Water-soluble Drug." Drug Development and Industrial Pharmacy, vol. 38, no. 7, 2012, pp. 883-92.
Bandivadeka MM, Pancholi SS, Kaul-Ghanekar R, et al. Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug. Drug Dev Ind Pharm. 2012;38(7):883-92.
Bandivadeka, M. M., Pancholi, S. S., Kaul-Ghanekar, R., Choudhari, A., & Koppikar, S. (2012). Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug. Drug Development and Industrial Pharmacy, 38(7), 883-92. https://doi.org/10.3109/03639045.2011.631548
Bandivadeka MM, et al. Self-microemulsifying Smaller Molecular Volume Oil (Capmul MCM) Using Non-ionic Surfactants: a Delivery System for Poorly Water-soluble Drug. Drug Dev Ind Pharm. 2012;38(7):883-92. PubMed PMID: 22087760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug. AU - Bandivadeka,Mithun Mohanraor, AU - Pancholi,Shyam Sundar, AU - Kaul-Ghanekar,Ruchika, AU - Choudhari,Amit, AU - Koppikar,Soumya, Y1 - 2011/11/16/ PY - 2011/11/18/entrez PY - 2011/11/18/pubmed PY - 2015/5/30/medline SP - 883 EP - 92 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 38 IS - 7 N2 - The main purpose of this work is to formulate self-microemulsifying drug delivery system (SMEDDS) using smaller molecular oil with Atorvastatin calcium as a model drug. Solubility of the selected drug was accessed in oils and surfactants. Percent transmittance (%T) test study was performed to identify the efficient self-microemulsifying formulations. Those formulations which showed higher value for %T were evaluated for droplet size, polydispersity index, ζ potential, refractive index and cloud point measurement. Effect of drug loading on droplet size, increasing dilution in different media, thermodynamic stability and in vitro dissolution was performed to observe the performance of the selected formulation. Further cytotoxicity and permeation enhancement studies were carried out on Caco2 cell lines. Of all the oils accessed for drug solubility, Capmul MCM showed higher solubility capacity for Atorvastatin calcium. Capmul MCM was better microemulsified using combination of Tween 20 and Labrasol surfactant. Droplet size was as low as 86.93 nm with polydispersity index and ζ potential at 0.195 ± 0.011 and -7.27 ± 3.11 mV respectively. The selected undiluted formulation showed refractive index values ranging from 1.40 to 1.47 indicating the isotropicity of the formulation. The selected formulation was robust to dilution in different media and thermodynamically stable. Dissolution profile was enhanced for the selected drug as compared to marketed formulation with t85% and DE values at 10 min and 80.15 respectively. Also cytotoxicity measurement showed minimum effect with good permeation enhancing capacity. Thus our study demonstrates the use of smaller molecular oil (Capmul MCM) for developing self-microemulsifying drug delivery system for better in vitro and in vivo performance. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/22087760/Self_microemulsifying_smaller_molecular_volume_oil__Capmul_MCM__using_non_ionic_surfactants:_a_delivery_system_for_poorly_water_soluble_drug_ DB - PRIME DP - Unbound Medicine ER -