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A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women.
Appl Physiol Nutr Metab 2011; 36(6):913-9AP

Abstract

This study examined the impact of brown seaweed on post-load plasma glucose and insulin concentrations in men and women. Twenty-three participants (11 men, 12 women) aged 19-59 years were recruited in this double-blind, randomized, placebo-controlled crossover study. The test product consisted of a commercially available blend of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) with known inhibitory action on α-amylase and α-glucosidase activities (InSea²). Two 250 mg seaweed capsules and 2 placebo capsules were consumed on each occasion 30 min prior to the consumption of 50 g of carbohydrates from bread. Plasma glucose and insulin concentrations were measured over a period of 3 h postcarbohydrate ingestion at predetermined time points. Both treatments were separated by a 1-week washout period. Data were analysed using mixed models for repeated measures. Compared with placebo, consumption of seaweed was associated with a 12.1% reduction in the insulin incremental area under the curve (p = 0.04, adjusted for baseline) and a 7.9% increase in the Cederholm index of insulin sensitivity (p < 0.05). The single ingestion of 500 mg of brown seaweed had no significant effect on the glucose response (p = 0.24, adjusted for baseline). Glucose and insulin responses were similar between men and women. Consumption of the seaweed capsules was not associated with any adverse event. These data suggest that brown seaweed may alter the insulin homeostasis in response to carbohydrate ingestion.

Authors+Show Affiliations

Institute of Nutraceuticals and Functional Foods, Laval University, QC G1V 0A6, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22087795

Citation

Paradis, Marie-Eve, et al. "A Randomised Crossover Placebo-controlled Trial Investigating the Effect of Brown Seaweed (Ascophyllum Nodosum and Fucus Vesiculosus) On Postchallenge Plasma Glucose and Insulin Levels in Men and Women." Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, vol. 36, no. 6, 2011, pp. 913-9.
Paradis ME, Couture P, Lamarche B. A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. Appl Physiol Nutr Metab. 2011;36(6):913-9.
Paradis, M. E., Couture, P., & Lamarche, B. (2011). A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 36(6), pp. 913-9. doi:10.1139/h11-115.
Paradis ME, Couture P, Lamarche B. A Randomised Crossover Placebo-controlled Trial Investigating the Effect of Brown Seaweed (Ascophyllum Nodosum and Fucus Vesiculosus) On Postchallenge Plasma Glucose and Insulin Levels in Men and Women. Appl Physiol Nutr Metab. 2011;36(6):913-9. PubMed PMID: 22087795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. AU - Paradis,Marie-Eve, AU - Couture,Patrick, AU - Lamarche,Benoît, Y1 - 2011/11/16/ PY - 2011/11/18/entrez PY - 2011/11/18/pubmed PY - 2012/3/9/medline SP - 913 EP - 9 JF - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JO - Appl Physiol Nutr Metab VL - 36 IS - 6 N2 - This study examined the impact of brown seaweed on post-load plasma glucose and insulin concentrations in men and women. Twenty-three participants (11 men, 12 women) aged 19-59 years were recruited in this double-blind, randomized, placebo-controlled crossover study. The test product consisted of a commercially available blend of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) with known inhibitory action on α-amylase and α-glucosidase activities (InSea²). Two 250 mg seaweed capsules and 2 placebo capsules were consumed on each occasion 30 min prior to the consumption of 50 g of carbohydrates from bread. Plasma glucose and insulin concentrations were measured over a period of 3 h postcarbohydrate ingestion at predetermined time points. Both treatments were separated by a 1-week washout period. Data were analysed using mixed models for repeated measures. Compared with placebo, consumption of seaweed was associated with a 12.1% reduction in the insulin incremental area under the curve (p = 0.04, adjusted for baseline) and a 7.9% increase in the Cederholm index of insulin sensitivity (p < 0.05). The single ingestion of 500 mg of brown seaweed had no significant effect on the glucose response (p = 0.24, adjusted for baseline). Glucose and insulin responses were similar between men and women. Consumption of the seaweed capsules was not associated with any adverse event. These data suggest that brown seaweed may alter the insulin homeostasis in response to carbohydrate ingestion. SN - 1715-5312 UR - https://www.unboundmedicine.com/medline/citation/22087795/A_randomised_crossover_placebo_controlled_trial_investigating_the_effect_of_brown_seaweed__Ascophyllum_nodosum_and_Fucus_vesiculosus__on_postchallenge_plasma_glucose_and_insulin_levels_in_men_and_women_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/h11-115?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -