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Alcohol-associated haemolysis in Zieve's syndrome: a clinical and laboratory study of five cases.
Clin Lab Haematol. 1990; 12(2):159-67.CL

Abstract

In 1958 Zieve described a syndrome of jaundice, hyperlipidaemia, and transient haemolytic anaemia associated with alcohol abuse. The clinical and laboratory features of five cases are reviewed. All patients presented with acute abdominal pain and fever. Four had a history of a recent alcohol binge. Hyperlipidaemia was present in two patients; this subsided before the onset of haemolysis. The red cells showed features of an acquired pyruvate kinase deficiency: an increased autohaemolysis with only partial correction with glucose, low red cell ATP, and instability of pyruvate kinase when haemolysate was heated to 55 degrees C. These changes were not observed in a control group of chronic alcoholics without haemolysis.

Authors+Show Affiliations

Department of Haematology, Royal Hospital, Hobart, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2208946

Citation

Melrose, W D., et al. "Alcohol-associated Haemolysis in Zieve's Syndrome: a Clinical and Laboratory Study of Five Cases." Clinical and Laboratory Haematology, vol. 12, no. 2, 1990, pp. 159-67.
Melrose WD, Bell PA, Jupe DM, et al. Alcohol-associated haemolysis in Zieve's syndrome: a clinical and laboratory study of five cases. Clin Lab Haematol. 1990;12(2):159-67.
Melrose, W. D., Bell, P. A., Jupe, D. M., & Baikie, M. J. (1990). Alcohol-associated haemolysis in Zieve's syndrome: a clinical and laboratory study of five cases. Clinical and Laboratory Haematology, 12(2), 159-67.
Melrose WD, et al. Alcohol-associated Haemolysis in Zieve's Syndrome: a Clinical and Laboratory Study of Five Cases. Clin Lab Haematol. 1990;12(2):159-67. PubMed PMID: 2208946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol-associated haemolysis in Zieve's syndrome: a clinical and laboratory study of five cases. AU - Melrose,W D, AU - Bell,P A, AU - Jupe,D M, AU - Baikie,M J, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 159 EP - 67 JF - Clinical and laboratory haematology JO - Clin Lab Haematol VL - 12 IS - 2 N2 - In 1958 Zieve described a syndrome of jaundice, hyperlipidaemia, and transient haemolytic anaemia associated with alcohol abuse. The clinical and laboratory features of five cases are reviewed. All patients presented with acute abdominal pain and fever. Four had a history of a recent alcohol binge. Hyperlipidaemia was present in two patients; this subsided before the onset of haemolysis. The red cells showed features of an acquired pyruvate kinase deficiency: an increased autohaemolysis with only partial correction with glucose, low red cell ATP, and instability of pyruvate kinase when haemolysate was heated to 55 degrees C. These changes were not observed in a control group of chronic alcoholics without haemolysis. SN - 0141-9854 UR - https://www.unboundmedicine.com/medline/citation/2208946/Alcohol-associated_haemolysis_in_Zieve's_syndrome:_a_clinical_and_laboratory_study_of_five_cases. L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0141-9854&date=1990&volume=12&issue=2&spage=159 DB - PRIME DP - Unbound Medicine ER -