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Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study.
Photodermatol Photoimmunol Photomed. 2011 Dec; 27(6):294-6.PP

Abstract

BACKGROUND

Combination of topical methoxsalen and narrowband ultraviolet B (NBUVB) was shown to be more effective than NBUVB alone in treating plaque-type psoriasis.

OBJECTIVE

To find out whether topical methoxsalen and NBUVB had any benefit in induction of remission on treatment-resistant plaques of psoriasis on the legs in comparison with NBUVB alone.

METHODS

Ten patients were included. Two symmetric lesions with similar Psoriasis Severity Index score on the lower legs were randomly assigned to be treated with cold cream as placebo or 0.1% 8-methoxypsoralen (8MOP) cream 15 min before phototherapy with NBUVB. Phototherapy was given three times per week for up to three months. Severity scores were recorded each week and side effects were observed before each session.

RESULTS

Significant decrease in the severity score was observed in both groups (P-value < 0.001), but none of the lesions cleared completely at the end of the study. The decrease of the score in the 8MOP arm was greater than the control arm; however, the difference was not significant. The only side effect was pigmentation that occurred in all of the 8MOP-treated patients after 2 weeks.

CONCLUSION

We could not confirm any significant benefit of topical methoxsalen and NBUVB in comparison to NBUVB alone in treating resistant plaques of psoriasis on the legs.

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Authors+Show Affiliations

Ehsani AH
Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
Ghaninejad H
No affiliation info available
Kiani A
No affiliation info available
Daneshpazhooh M
No affiliation info available
Hosseini SH
No affiliation info available
Noormohammadpoor P
No affiliation info available

MeSH

AdultAgedFemaleHumansMaleMethoxsalenMiddle AgedPhotosensitizing AgentsPsoriasisSeverity of Illness IndexSkin PigmentationTime FactorsUltraviolet RaysUltraviolet Therapy

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22092732

Citation

Ehsani, Amir-Houshang, et al. "Comparison of Topical 8-methoxypsoralen and Narrowband Ultraviolet B With Narrowband Ultraviolet B Alone in Treatment-resistant Sites in Plaque-type Psoriasis: a Placebo-controlled Study." Photodermatology, Photoimmunology & Photomedicine, vol. 27, no. 6, 2011, pp. 294-6.
Ehsani AH, Ghaninejad H, Kiani A, et al. Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study. Photodermatol Photoimmunol Photomed. 2011;27(6):294-6.
Ehsani, A. H., Ghaninejad, H., Kiani, A., Daneshpazhooh, M., Hosseini, S. H., & Noormohammadpoor, P. (2011). Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study. Photodermatology, Photoimmunology & Photomedicine, 27(6), 294-6. https://doi.org/10.1111/j.1600-0781.2011.00615.x
Ehsani AH, et al. Comparison of Topical 8-methoxypsoralen and Narrowband Ultraviolet B With Narrowband Ultraviolet B Alone in Treatment-resistant Sites in Plaque-type Psoriasis: a Placebo-controlled Study. Photodermatol Photoimmunol Photomed. 2011;27(6):294-6. PubMed PMID: 22092732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study. AU - Ehsani,Amir-Houshang, AU - Ghaninejad,Haydeh, AU - Kiani,Amin, AU - Daneshpazhooh,Maryam, AU - Hosseini,S Hamed, AU - Noormohammadpoor,Pedram, PY - 2011/11/19/entrez PY - 2011/11/19/pubmed PY - 2012/3/16/medline SP - 294 EP - 6 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 27 IS - 6 N2 - BACKGROUND: Combination of topical methoxsalen and narrowband ultraviolet B (NBUVB) was shown to be more effective than NBUVB alone in treating plaque-type psoriasis. OBJECTIVE: To find out whether topical methoxsalen and NBUVB had any benefit in induction of remission on treatment-resistant plaques of psoriasis on the legs in comparison with NBUVB alone. METHODS: Ten patients were included. Two symmetric lesions with similar Psoriasis Severity Index score on the lower legs were randomly assigned to be treated with cold cream as placebo or 0.1% 8-methoxypsoralen (8MOP) cream 15 min before phototherapy with NBUVB. Phototherapy was given three times per week for up to three months. Severity scores were recorded each week and side effects were observed before each session. RESULTS: Significant decrease in the severity score was observed in both groups (P-value < 0.001), but none of the lesions cleared completely at the end of the study. The decrease of the score in the 8MOP arm was greater than the control arm; however, the difference was not significant. The only side effect was pigmentation that occurred in all of the 8MOP-treated patients after 2 weeks. CONCLUSION: We could not confirm any significant benefit of topical methoxsalen and NBUVB in comparison to NBUVB alone in treating resistant plaques of psoriasis on the legs. SN - 1600-0781 UR - https://www.unboundmedicine.com/medline/citation/22092732/Comparison_of_topical_8_methoxypsoralen_and_narrowband_ultraviolet_B_with_narrowband_ultraviolet_B_alone_in_treatment_resistant_sites_in_plaque_type_psoriasis:_a_placebo_controlled_study_ L2 - https://doi.org/10.1111/j.1600-0781.2011.00615.x DB - PRIME DP - Unbound Medicine ER -