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Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation.
Eur J Cancer Prev 2012; 21(4):350-9EJ

Abstract

Inconsistent results on the relationship between alcohol drinking and prostate cancer have been found. In order to provide a definite quantification of the dose-risk relation, we investigated the risk of prostate cancer at different levels of alcohol consumption, by conducting a meta-analysis of epidemiological studies. We performed a literature search using PubMed of all case-control and cohort studies published as original articles in English up to December 2010. We identified 50 case-control and 22 cohort studies, including a total of 52 899 prostate cancer cases. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates. We performed a dose-risk analysis using nonlinear random-effects meta-regression models. The overall relative risk for any alcohol drinking compared with non/occasional drinking was 1.06 [95% confidence interval (CI), 1.01-1.10]. The relative risks were 1.05 (95% CI, 1.02-1.08), 1.06 (95% CI, 1.01-1.11), and 1.08 (95% CI, 0.97-1.20) for light (≤1 drink/day), moderate (>1 to <4 drinks/day), and heavy alcohol drinking (≥4 drinks/day), respectively. This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and prostate cancer, even at high doses.

Authors+Show Affiliations

Departments of Clinical Medicine and Prevention, Centre of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Via Cadore 48, Monza, Italy. m.rota9@campus.unimib.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22095143

Citation

Rota, Matteo, et al. "Alcohol Consumption and Prostate Cancer Risk: a Meta-analysis of the Dose-risk Relation." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 21, no. 4, 2012, pp. 350-9.
Rota M, Scotti L, Turati F, et al. Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. Eur J Cancer Prev. 2012;21(4):350-9.
Rota, M., Scotti, L., Turati, F., Tramacere, I., Islami, F., Bellocco, R., ... Bagnardi, V. (2012). Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 21(4), pp. 350-9. doi:10.1097/CEJ.0b013e32834dbc11.
Rota M, et al. Alcohol Consumption and Prostate Cancer Risk: a Meta-analysis of the Dose-risk Relation. Eur J Cancer Prev. 2012;21(4):350-9. PubMed PMID: 22095143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. AU - Rota,Matteo, AU - Scotti,Lorenza, AU - Turati,Federica, AU - Tramacere,Irene, AU - Islami,Farhad, AU - Bellocco,Rino, AU - Negri,Eva, AU - Corrao,Giovanni, AU - Boffetta,Paolo, AU - La Vecchia,Carlo, AU - Bagnardi,Vincenzo, PY - 2011/11/19/entrez PY - 2011/11/19/pubmed PY - 2012/9/27/medline SP - 350 EP - 9 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 21 IS - 4 N2 - Inconsistent results on the relationship between alcohol drinking and prostate cancer have been found. In order to provide a definite quantification of the dose-risk relation, we investigated the risk of prostate cancer at different levels of alcohol consumption, by conducting a meta-analysis of epidemiological studies. We performed a literature search using PubMed of all case-control and cohort studies published as original articles in English up to December 2010. We identified 50 case-control and 22 cohort studies, including a total of 52 899 prostate cancer cases. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates. We performed a dose-risk analysis using nonlinear random-effects meta-regression models. The overall relative risk for any alcohol drinking compared with non/occasional drinking was 1.06 [95% confidence interval (CI), 1.01-1.10]. The relative risks were 1.05 (95% CI, 1.02-1.08), 1.06 (95% CI, 1.01-1.11), and 1.08 (95% CI, 0.97-1.20) for light (≤1 drink/day), moderate (>1 to <4 drinks/day), and heavy alcohol drinking (≥4 drinks/day), respectively. This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and prostate cancer, even at high doses. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/22095143/Alcohol_consumption_and_prostate_cancer_risk:_a_meta_analysis_of_the_dose_risk_relation_ L2 - http://Insights.ovid.com/pubmed?pmid=22095143 DB - PRIME DP - Unbound Medicine ER -