Tags

Type your tag names separated by a space and hit enter

Family history of liver cancer and hepatocellular carcinoma.
Hepatology 2012; 55(5):1416-25Hep

Abstract

Familial clustering of hepatocellular carcinoma (HCC) has been frequently reported in eastern Asiatic countries, where hepatitis B infection is common. Little is known about the relationship between family history of liver cancer and HCC in Western populations. We carried out a case-control study in Italy, involving 229 HCC cases and 431 hospital controls. Data on family history were summarized through a binary indicator (yes/no) and a family history score (FHscore), considering selected family characteristics. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from unconditional multiple logistic regression models, including terms for age, sex, study center, education, tobacco smoking, alcohol drinking, hepatitis B surface antigen, and/or anti-hepatitis C virus positivity. We also performed a meta-analysis on family history of liver cancer and liver cancer updated to April 2011 using random-effects models. After adjustment for chronic infection with hepatitis B/C viruses, family history of liver cancer was associated with HCC risk, when using both the binary indicator (OR, 2.38; 95% CI, 1.01-5.58) and the FHscore, with increasing ORs for successive score categories. Compared to subjects without family history and no chronic infection with hepatitis B/C viruses, the OR for those exposed to both risk factors was 72.48 (95% CI, 21.92-239.73). In the meta-analysis, based on nine case-control and four cohort studies, for a total of approximately 3,600 liver cancer cases, the pooled relative risk for family history of liver cancer was 2.50 (95% CI, 2.06-3.03).

CONCLUSION

A family history of liver cancer increases HCC risk, independently of hepatitis. The combination of family history of liver cancer and hepatitis B/C serum markers is associated with an over 70-fold elevated HCC risk.

Authors+Show Affiliations

Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22095619

Citation

Turati, Federica, et al. "Family History of Liver Cancer and Hepatocellular Carcinoma." Hepatology (Baltimore, Md.), vol. 55, no. 5, 2012, pp. 1416-25.
Turati F, Edefonti V, Talamini R, et al. Family history of liver cancer and hepatocellular carcinoma. Hepatology. 2012;55(5):1416-25.
Turati, F., Edefonti, V., Talamini, R., Ferraroni, M., Malvezzi, M., Bravi, F., ... Decarli, A. (2012). Family history of liver cancer and hepatocellular carcinoma. Hepatology (Baltimore, Md.), 55(5), pp. 1416-25. doi:10.1002/hep.24794.
Turati F, et al. Family History of Liver Cancer and Hepatocellular Carcinoma. Hepatology. 2012;55(5):1416-25. PubMed PMID: 22095619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of liver cancer and hepatocellular carcinoma. AU - Turati,Federica, AU - Edefonti,Valeria, AU - Talamini,Renato, AU - Ferraroni,Monica, AU - Malvezzi,Matteo, AU - Bravi,Francesca, AU - Franceschi,Silvia, AU - Montella,Maurizio, AU - Polesel,Jerry, AU - Zucchetto,Antonella, AU - La Vecchia,Carlo, AU - Negri,Eva, AU - Decarli,Adriano, Y1 - 2012/03/21/ PY - 2011/07/18/received PY - 2011/10/27/accepted PY - 2011/11/19/entrez PY - 2011/11/19/pubmed PY - 2012/6/20/medline SP - 1416 EP - 25 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 55 IS - 5 N2 - UNLABELLED: Familial clustering of hepatocellular carcinoma (HCC) has been frequently reported in eastern Asiatic countries, where hepatitis B infection is common. Little is known about the relationship between family history of liver cancer and HCC in Western populations. We carried out a case-control study in Italy, involving 229 HCC cases and 431 hospital controls. Data on family history were summarized through a binary indicator (yes/no) and a family history score (FHscore), considering selected family characteristics. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from unconditional multiple logistic regression models, including terms for age, sex, study center, education, tobacco smoking, alcohol drinking, hepatitis B surface antigen, and/or anti-hepatitis C virus positivity. We also performed a meta-analysis on family history of liver cancer and liver cancer updated to April 2011 using random-effects models. After adjustment for chronic infection with hepatitis B/C viruses, family history of liver cancer was associated with HCC risk, when using both the binary indicator (OR, 2.38; 95% CI, 1.01-5.58) and the FHscore, with increasing ORs for successive score categories. Compared to subjects without family history and no chronic infection with hepatitis B/C viruses, the OR for those exposed to both risk factors was 72.48 (95% CI, 21.92-239.73). In the meta-analysis, based on nine case-control and four cohort studies, for a total of approximately 3,600 liver cancer cases, the pooled relative risk for family history of liver cancer was 2.50 (95% CI, 2.06-3.03). CONCLUSION: A family history of liver cancer increases HCC risk, independently of hepatitis. The combination of family history of liver cancer and hepatitis B/C serum markers is associated with an over 70-fold elevated HCC risk. SN - 1527-3350 UR - https://www.unboundmedicine.com/medline/citation/22095619/Family_history_of_liver_cancer_and_hepatocellular_carcinoma_ L2 - https://doi.org/10.1002/hep.24794 DB - PRIME DP - Unbound Medicine ER -