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Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa.
Emerg Infect Dis. 2011 Nov; 17(11):2113-21.EI

Abstract

Cholera was absent from the island of Hispaniola at least a century before an outbreak that began in Haiti in the fall of 2010. Pulsed-field gel electrophoresis (PFGE) analysis of clinical isolates from the Haiti outbreak and recent global travelers returning to the United States showed indistinguishable PFGE fingerprints. To better explore the genetic ancestry of the Haiti outbreak strain, we acquired 23 whole-genome Vibrio cholerae sequences: 9 isolates obtained in Haiti or the Dominican Republic, 12 PFGE pattern-matched isolates linked to Asia or Africa, and 2 nonmatched outliers from the Western Hemisphere. Phylogenies for whole-genome sequences and core genome single-nucleotide polymorphisms showed that the Haiti outbreak strain is genetically related to strains originating in India and Cameroon. However, because no identical genetic match was found among sequenced contemporary isolates, a definitive genetic origin for the outbreak in Haiti remains speculative.

Authors+Show Affiliations

Public Health Agency of Canada, Winnipeg, Manitoba, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22099115

Citation

Reimer, Aleisha R., et al. "Comparative Genomics of Vibrio Cholerae From Haiti, Asia, and Africa." Emerging Infectious Diseases, vol. 17, no. 11, 2011, pp. 2113-21.
Reimer AR, Van Domselaar G, Stroika S, et al. Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa. Emerging Infect Dis. 2011;17(11):2113-21.
Reimer, A. R., Van Domselaar, G., Stroika, S., Walker, M., Kent, H., Tarr, C., Talkington, D., Rowe, L., Olsen-Rasmussen, M., Frace, M., Sammons, S., Dahourou, G. A., Boncy, J., Smith, A. M., Mabon, P., Petkau, A., Graham, M., Gilmour, M. W., & Gerner-Smidt, P. (2011). Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa. Emerging Infectious Diseases, 17(11), 2113-21. https://doi.org/10.3201/eid1711.110794
Reimer AR, et al. Comparative Genomics of Vibrio Cholerae From Haiti, Asia, and Africa. Emerging Infect Dis. 2011;17(11):2113-21. PubMed PMID: 22099115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa. AU - Reimer,Aleisha R, AU - Van Domselaar,Gary, AU - Stroika,Steven, AU - Walker,Matthew, AU - Kent,Heather, AU - Tarr,Cheryl, AU - Talkington,Deborah, AU - Rowe,Lori, AU - Olsen-Rasmussen,Melissa, AU - Frace,Michael, AU - Sammons,Scott, AU - Dahourou,Georges Anicet, AU - Boncy,Jacques, AU - Smith,Anthony M, AU - Mabon,Philip, AU - Petkau,Aaron, AU - Graham,Morag, AU - Gilmour,Matthew W, AU - Gerner-Smidt,Peter, AU - ,, PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2012/4/28/medline SP - 2113 EP - 21 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 17 IS - 11 N2 - Cholera was absent from the island of Hispaniola at least a century before an outbreak that began in Haiti in the fall of 2010. Pulsed-field gel electrophoresis (PFGE) analysis of clinical isolates from the Haiti outbreak and recent global travelers returning to the United States showed indistinguishable PFGE fingerprints. To better explore the genetic ancestry of the Haiti outbreak strain, we acquired 23 whole-genome Vibrio cholerae sequences: 9 isolates obtained in Haiti or the Dominican Republic, 12 PFGE pattern-matched isolates linked to Asia or Africa, and 2 nonmatched outliers from the Western Hemisphere. Phylogenies for whole-genome sequences and core genome single-nucleotide polymorphisms showed that the Haiti outbreak strain is genetically related to strains originating in India and Cameroon. However, because no identical genetic match was found among sequenced contemporary isolates, a definitive genetic origin for the outbreak in Haiti remains speculative. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/22099115/Comparative_genomics_of_Vibrio_cholerae_from_Haiti_Asia_and_Africa_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22099115/ DB - PRIME DP - Unbound Medicine ER -