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Relation of renal function to risk for incident atrial fibrillation in women.
Am J Cardiol 2012; 109(4):538-42AJ

Abstract

Few prospective studies have explored the association between renal function and risk for incident atrial fibrillation (AF) in apparently healthy populations. A total of 24,746 women participating in the Women's Health Study who were free of cardiovascular disease and AF and provided blood samples at baseline were prospectively followed for incident AF from 1993 to 2010. AF events were confirmed by medical chart review. Estimated glomerular filtration rate (eGFR) was calculated from baseline creatinine using the Chronic Kidney Disease Epidemiology (CKD-EPI) equation. Cox models were used to estimate hazard ratios and 95% confidence intervals (CIs) for incident AF across eGFR categories controlling for AF risk factors. During a median of 15.4 years of follow-up, 786 incident AF events occurred. The multivariate-adjusted hazard ratios for incident AF across eGFR categories (<60, 60 to 74.9, 75 to 89, and ≥90 ml/min/1.73 m(2)) were 1.36 (95% CI 1.00 to 1.84), 0.90 (95% CI 0.71 to 1.14), 0.99 (95% CI 0.84 to 1.18) and 1.00, respectively, without evidence of a linear association (P for trend = 0.48). Similarly, there was no significant curvilinear association (quadratic p = 0.10) in multivariate analysis across categories. Compared to women with eGFRs ≥60 ml/min/1.73 m(2), the 1,008 women with eGFRs <60 ml/min/1.73 m(2) had a multivariate-adjusted hazard ratio for AF of 1.39 (95% CI 1.04 to 1.86, p = 0.03). In conclusion, no significant linear or curvilinear relation was observed between incident AF and less severe impairment of renal function in this large prospective cohort of women. However, a significant elevation in AF risk was observed at a threshold eGFR of <60 ml/min/1.73 m(2).

Authors+Show Affiliations

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. rsandhu2@ualberta.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22100025

Citation

Sandhu, Roopinder K., et al. "Relation of Renal Function to Risk for Incident Atrial Fibrillation in Women." The American Journal of Cardiology, vol. 109, no. 4, 2012, pp. 538-42.
Sandhu RK, Kurth T, Conen D, et al. Relation of renal function to risk for incident atrial fibrillation in women. Am J Cardiol. 2012;109(4):538-42.
Sandhu, R. K., Kurth, T., Conen, D., Cook, N. R., Ridker, P. M., & Albert, C. M. (2012). Relation of renal function to risk for incident atrial fibrillation in women. The American Journal of Cardiology, 109(4), pp. 538-42. doi:10.1016/j.amjcard.2011.10.006.
Sandhu RK, et al. Relation of Renal Function to Risk for Incident Atrial Fibrillation in Women. Am J Cardiol. 2012 Feb 15;109(4):538-42. PubMed PMID: 22100025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of renal function to risk for incident atrial fibrillation in women. AU - Sandhu,Roopinder K, AU - Kurth,Tobias, AU - Conen,David, AU - Cook,Nancy R, AU - Ridker,Paul M, AU - Albert,Christine M, Y1 - 2011/11/17/ PY - 2011/07/18/received PY - 2011/10/07/revised PY - 2011/10/07/accepted PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2012/4/5/medline SP - 538 EP - 42 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 109 IS - 4 N2 - Few prospective studies have explored the association between renal function and risk for incident atrial fibrillation (AF) in apparently healthy populations. A total of 24,746 women participating in the Women's Health Study who were free of cardiovascular disease and AF and provided blood samples at baseline were prospectively followed for incident AF from 1993 to 2010. AF events were confirmed by medical chart review. Estimated glomerular filtration rate (eGFR) was calculated from baseline creatinine using the Chronic Kidney Disease Epidemiology (CKD-EPI) equation. Cox models were used to estimate hazard ratios and 95% confidence intervals (CIs) for incident AF across eGFR categories controlling for AF risk factors. During a median of 15.4 years of follow-up, 786 incident AF events occurred. The multivariate-adjusted hazard ratios for incident AF across eGFR categories (<60, 60 to 74.9, 75 to 89, and ≥90 ml/min/1.73 m(2)) were 1.36 (95% CI 1.00 to 1.84), 0.90 (95% CI 0.71 to 1.14), 0.99 (95% CI 0.84 to 1.18) and 1.00, respectively, without evidence of a linear association (P for trend = 0.48). Similarly, there was no significant curvilinear association (quadratic p = 0.10) in multivariate analysis across categories. Compared to women with eGFRs ≥60 ml/min/1.73 m(2), the 1,008 women with eGFRs <60 ml/min/1.73 m(2) had a multivariate-adjusted hazard ratio for AF of 1.39 (95% CI 1.04 to 1.86, p = 0.03). In conclusion, no significant linear or curvilinear relation was observed between incident AF and less severe impairment of renal function in this large prospective cohort of women. However, a significant elevation in AF risk was observed at a threshold eGFR of <60 ml/min/1.73 m(2). SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/22100025/Relation_of_renal_function_to_risk_for_incident_atrial_fibrillation_in_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(11)03041-4 DB - PRIME DP - Unbound Medicine ER -