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Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial.
Clin Infect Dis. 2012 Feb 01; 54(3):340-6.CI

Abstract

BACKGROUND

Cranberry juice prevents recurrences of urinary tract infections (UTIs) in adult women. The objective of this study was to evaluate whether cranberry juice is effective in preventing UTI recurrences in children.

METHODS

A double-blind randomized placebo-controlled trial was performed in 7 hospitals in Finland. A total of 263 children treated for UTI were randomized to receive either cranberry juice (n = 129) or placebo (n = 134) for 6 months. Eight children were omitted because of protocol violations, leaving 255 children for the final analyses. The children were monitored for 1 year, and their recurrent UTIs were recorded.

RESULTS

Twenty children (16%) in the cranberry group and 28 (22%) in the placebo group had at least 1 recurrent UTI (difference, -6%; 95% confidence interval [CI], -16 to 4%; P = .21). There were no differences in timing between these first recurrences (P = .32). Episodes of UTI totaled 27 and 47 in the cranberry and placebo groups, respectively, and the UTI incidence density per person-year at risk was 0.16 episodes lower in the cranberry group (95% CI, -.31 to -.01; P = .035). The children in the cranberry group had significantly fewer days on antimicrobials (-6 days per patient-year; 95% CI, -7 to -5; P < .001).

CONCLUSIONS

The intervention did not significantly reduce the number of children who experienced a recurrence of UTI, but it was effective in reducing the actual number of recurrences and related antimicrobial use.

Authors+Show Affiliations

Department of Paediatrics, Oulu University Hospital, University of Oulu, Finland. jarmo.salo@oulu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22100577

Citation

Salo, Jarmo, et al. "Cranberry Juice for the Prevention of Recurrences of Urinary Tract Infections in Children: a Randomized Placebo-controlled Trial." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 54, no. 3, 2012, pp. 340-6.
Salo J, Uhari M, Helminen M, et al. Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. Clin Infect Dis. 2012;54(3):340-6.
Salo, J., Uhari, M., Helminen, M., Korppi, M., Nieminen, T., Pokka, T., & Kontiokari, T. (2012). Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 54(3), 340-6. https://doi.org/10.1093/cid/cir801
Salo J, et al. Cranberry Juice for the Prevention of Recurrences of Urinary Tract Infections in Children: a Randomized Placebo-controlled Trial. Clin Infect Dis. 2012 Feb 1;54(3):340-6. PubMed PMID: 22100577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. AU - Salo,Jarmo, AU - Uhari,Matti, AU - Helminen,Merja, AU - Korppi,Matti, AU - Nieminen,Tea, AU - Pokka,Tytti, AU - Kontiokari,Tero, Y1 - 2011/11/18/ PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2012/5/10/medline SP - 340 EP - 6 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 54 IS - 3 N2 - BACKGROUND: Cranberry juice prevents recurrences of urinary tract infections (UTIs) in adult women. The objective of this study was to evaluate whether cranberry juice is effective in preventing UTI recurrences in children. METHODS: A double-blind randomized placebo-controlled trial was performed in 7 hospitals in Finland. A total of 263 children treated for UTI were randomized to receive either cranberry juice (n = 129) or placebo (n = 134) for 6 months. Eight children were omitted because of protocol violations, leaving 255 children for the final analyses. The children were monitored for 1 year, and their recurrent UTIs were recorded. RESULTS: Twenty children (16%) in the cranberry group and 28 (22%) in the placebo group had at least 1 recurrent UTI (difference, -6%; 95% confidence interval [CI], -16 to 4%; P = .21). There were no differences in timing between these first recurrences (P = .32). Episodes of UTI totaled 27 and 47 in the cranberry and placebo groups, respectively, and the UTI incidence density per person-year at risk was 0.16 episodes lower in the cranberry group (95% CI, -.31 to -.01; P = .035). The children in the cranberry group had significantly fewer days on antimicrobials (-6 days per patient-year; 95% CI, -7 to -5; P < .001). CONCLUSIONS: The intervention did not significantly reduce the number of children who experienced a recurrence of UTI, but it was effective in reducing the actual number of recurrences and related antimicrobial use. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/22100577/Cranberry_juice_for_the_prevention_of_recurrences_of_urinary_tract_infections_in_children:_a_randomized_placebo_controlled_trial_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cir801 DB - PRIME DP - Unbound Medicine ER -