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Effects of Ω-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study.
Int J Cardiol 2013; 166(2):340-6IJ

Abstract

BACKGROUND

Smoking is associated with endothelial dysfunction and arterial stiffness. Supplementation of Ω-3 PUFAs is associated with better prognosis. Aim of this study was to evaluate the effects of Ω-3 polyunsaturated fatty acids (PUFAs) supplementation on smoking-induced impairment of arterial function.

METHODS

We studied the effect of a 12 weeks oral treatment with 2gr/day of Ω-3 PUFAs in 20 healthy smokers on three occasions (day 0:baseline, day 28 and day 84). The study was carried out on two separate arms (Ω-3 fatty acids and placebo), according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before (pSm), immediately and 20min after cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. Circulating levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) were measured.

RESULTS

Compared with placebo, Ω-3 PUFAs treatment resulted in a significant improvement in pSm values of FMD (p<0.05), AIx (p<0.001) and PWV (p<0.01). Although, acute cigarette smoking decreased FMD and caused an increase in AIx and PWV, Ω-3 PUFAs treatment blunted the acute smoking-induced impairment of FMD (p<0.001), AIx (p<0.05) and PWV (p<0.05) and significantly decreased levels of TNFα (p<0.05) and IL-6 (p=0.01) and increased levels of PAI-1 (p=0.05).

CONCLUSIONS

Ω-3 PUFAs improved endothelial function and the elastic properties of the arterial tree in healthy smokers, with a parallel anti-inflammatory effect.

Authors+Show Affiliations

Department of Biological Chemistry, University of Athens Medical School, Athens Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22100606

Citation

Siasos, Gerasimos, et al. "Effects of Ω-3 Fatty Acids On Endothelial Function, Arterial Wall Properties, Inflammatory and Fibrinolytic Status in Smokers: a Cross Over Study." International Journal of Cardiology, vol. 166, no. 2, 2013, pp. 340-6.
Siasos G, Tousoulis D, Oikonomou E, et al. Effects of Ω-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study. Int J Cardiol. 2013;166(2):340-6.
Siasos, G., Tousoulis, D., Oikonomou, E., Zaromitidou, M., Verveniotis, A., Plastiras, A., ... Papavassiliou, A. G. (2013). Effects of Ω-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study. International Journal of Cardiology, 166(2), pp. 340-6. doi:10.1016/j.ijcard.2011.10.081.
Siasos G, et al. Effects of Ω-3 Fatty Acids On Endothelial Function, Arterial Wall Properties, Inflammatory and Fibrinolytic Status in Smokers: a Cross Over Study. Int J Cardiol. 2013 Jun 20;166(2):340-6. PubMed PMID: 22100606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Ω-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study. AU - Siasos,Gerasimos, AU - Tousoulis,Dimitris, AU - Oikonomou,Evangelos, AU - Zaromitidou,Marina, AU - Verveniotis,Aleksis, AU - Plastiras,Aris, AU - Kioufis,Stamatios, AU - Maniatis,Konstantinos, AU - Miliou,Antigoni, AU - Siasou,Zoi, AU - Stefanadis,Christodoulos, AU - Papavassiliou,Athanasios G, Y1 - 2011/11/17/ PY - 2011/09/06/received PY - 2011/10/18/accepted PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2014/2/14/medline SP - 340 EP - 6 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 166 IS - 2 N2 - BACKGROUND: Smoking is associated with endothelial dysfunction and arterial stiffness. Supplementation of Ω-3 PUFAs is associated with better prognosis. Aim of this study was to evaluate the effects of Ω-3 polyunsaturated fatty acids (PUFAs) supplementation on smoking-induced impairment of arterial function. METHODS: We studied the effect of a 12 weeks oral treatment with 2gr/day of Ω-3 PUFAs in 20 healthy smokers on three occasions (day 0:baseline, day 28 and day 84). The study was carried out on two separate arms (Ω-3 fatty acids and placebo), according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before (pSm), immediately and 20min after cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. Circulating levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) were measured. RESULTS: Compared with placebo, Ω-3 PUFAs treatment resulted in a significant improvement in pSm values of FMD (p<0.05), AIx (p<0.001) and PWV (p<0.01). Although, acute cigarette smoking decreased FMD and caused an increase in AIx and PWV, Ω-3 PUFAs treatment blunted the acute smoking-induced impairment of FMD (p<0.001), AIx (p<0.05) and PWV (p<0.05) and significantly decreased levels of TNFα (p<0.05) and IL-6 (p=0.01) and increased levels of PAI-1 (p=0.05). CONCLUSIONS: Ω-3 PUFAs improved endothelial function and the elastic properties of the arterial tree in healthy smokers, with a parallel anti-inflammatory effect. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/22100606/Effects_of_Ω_3_fatty_acids_on_endothelial_function_arterial_wall_properties_inflammatory_and_fibrinolytic_status_in_smokers:_a_cross_over_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(11)01955-3 DB - PRIME DP - Unbound Medicine ER -