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Vaccine effectiveness in preventing influenza hospitalizations in Navarre, Spain, 2010-2011: cohort and case-control study.
Vaccine 2012; 30(2):195-200V

Abstract

We evaluated the 2010-2011 seasonal influenza vaccine effectiveness in preventing hospitalizations. Using healthcare databases we defined the target population for vaccination in Navarre, Spain, consisting of 217,320 people with major chronic conditions or aged 60 years and older. All hospitalized patients with influenza-like illness (ILI) were swabbed for influenza testing. A total of 269 patients with ILI were hospitalized and 61 of them were found positive for influenza virus: 58 for A(H1N1)2009 and 3 for B virus. The incidence rates of hospitalization with laboratory-confirmed influenza were compared by vaccination status. In the Cox regression model adjusted for sex, age, children in the household, urban/rural residence, comorbidity, pandemic vaccination, pneumococcal vaccination, outpatient visits and hospitalization in the previous year, the seasonal vaccine effectiveness was 58% (95% CI: 16-79%). The nested test-negative case-control analysis gave an adjusted estimate of 59% (95% CI: 4-83%). These results suggest a moderate effect of the 2010-2011 seasonal influenza vaccine in preventing hospitalization in a risk population. The close estimates obtained in the cohort and the test-negative case-control analyses suggest good control of biases.

Authors+Show Affiliations

Instituto de Salud Pública de Navarra, Pamplona, Spain. jcastilc@navarra.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22100636

Citation

Castilla, Jesús, et al. "Vaccine Effectiveness in Preventing Influenza Hospitalizations in Navarre, Spain, 2010-2011: Cohort and Case-control Study." Vaccine, vol. 30, no. 2, 2012, pp. 195-200.
Castilla J, Martínez-Artola V, Salcedo E, et al. Vaccine effectiveness in preventing influenza hospitalizations in Navarre, Spain, 2010-2011: cohort and case-control study. Vaccine. 2012;30(2):195-200.
Castilla, J., Martínez-Artola, V., Salcedo, E., Martínez-Baz, I., Cenoz, M. G., Guevara, M., ... Barricarte, A. (2012). Vaccine effectiveness in preventing influenza hospitalizations in Navarre, Spain, 2010-2011: cohort and case-control study. Vaccine, 30(2), pp. 195-200. doi:10.1016/j.vaccine.2011.11.024.
Castilla J, et al. Vaccine Effectiveness in Preventing Influenza Hospitalizations in Navarre, Spain, 2010-2011: Cohort and Case-control Study. Vaccine. 2012 Jan 5;30(2):195-200. PubMed PMID: 22100636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccine effectiveness in preventing influenza hospitalizations in Navarre, Spain, 2010-2011: cohort and case-control study. AU - Castilla,Jesús, AU - Martínez-Artola,Víctor, AU - Salcedo,Esther, AU - Martínez-Baz,Iván, AU - Cenoz,Manuel García, AU - Guevara,Marcela, AU - Alvarez,Nerea, AU - Irisarri,Fátima, AU - Morán,Julio, AU - Barricarte,Aurelio, AU - ,, Y1 - 2011/11/18/ PY - 2011/07/22/received PY - 2011/10/31/revised PY - 2011/11/07/accepted PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2012/3/22/medline SP - 195 EP - 200 JF - Vaccine JO - Vaccine VL - 30 IS - 2 N2 - We evaluated the 2010-2011 seasonal influenza vaccine effectiveness in preventing hospitalizations. Using healthcare databases we defined the target population for vaccination in Navarre, Spain, consisting of 217,320 people with major chronic conditions or aged 60 years and older. All hospitalized patients with influenza-like illness (ILI) were swabbed for influenza testing. A total of 269 patients with ILI were hospitalized and 61 of them were found positive for influenza virus: 58 for A(H1N1)2009 and 3 for B virus. The incidence rates of hospitalization with laboratory-confirmed influenza were compared by vaccination status. In the Cox regression model adjusted for sex, age, children in the household, urban/rural residence, comorbidity, pandemic vaccination, pneumococcal vaccination, outpatient visits and hospitalization in the previous year, the seasonal vaccine effectiveness was 58% (95% CI: 16-79%). The nested test-negative case-control analysis gave an adjusted estimate of 59% (95% CI: 4-83%). These results suggest a moderate effect of the 2010-2011 seasonal influenza vaccine in preventing hospitalization in a risk population. The close estimates obtained in the cohort and the test-negative case-control analyses suggest good control of biases. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22100636/Vaccine_effectiveness_in_preventing_influenza_hospitalizations_in_Navarre_Spain_2010_2011:_cohort_and_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)01791-9 DB - PRIME DP - Unbound Medicine ER -