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Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study.
Int J Obstet Anesth 2012; 21(1):24-8IJ

Abstract

BACKGROUND

Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby. Animal studies suggest that in the presence of decreased blood volume, 5-HT may be an important factor inducing the Bezold Jarisch reflex via 5-HT3 receptors located in intracardiac vagal nerve endings. In this study, we evaluated the effect of ondansetron, as a 5-HT3 receptor antagonist, on the haemodynamic response following subarachnoid block in parturients undergoing elective caesarean section.

METHODS

Fifty-two parturients scheduled for elective caesarean section were randomly allocated into two groups. Before induction of spinal anaesthesia Group O (n=26) received intravenous ondansetron 4 mg; Group S (n=26) received normal saline. Blood pressure, heart rate and vasopressor requirements were assessed.

RESULTS

Decreases in mean arterial pressure were significantly lower in Group O than Group S from 14 min until 35 min. Patients in Group O required significantly less vasopressor (P=0.009) and had significantly lower incidences of nausea and vomiting (P=0.049).

CONCLUSION

Ondansetron 4 mg, given intravenously 5 min before subarachnoid block reduced hypotension and vasopressor use in parturients undergoing elective caesarean section.

Authors+Show Affiliations

Department of Anaesthesiology, Institute of Post Graduate Medical Education & Research, Kolkata, India.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22100822

Citation

Sahoo, T, et al. "Reduction in Spinal-induced Hypotension With Ondansetron in Parturients Undergoing Caesarean Section: a Double-blind Randomised, Placebo-controlled Study." International Journal of Obstetric Anesthesia, vol. 21, no. 1, 2012, pp. 24-8.
Sahoo T, SenDasgupta C, Goswami A, et al. Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. Int J Obstet Anesth. 2012;21(1):24-8.
Sahoo, T., SenDasgupta, C., Goswami, A., & Hazra, A. (2012). Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. International Journal of Obstetric Anesthesia, 21(1), pp. 24-8. doi:10.1016/j.ijoa.2011.08.002.
Sahoo T, et al. Reduction in Spinal-induced Hypotension With Ondansetron in Parturients Undergoing Caesarean Section: a Double-blind Randomised, Placebo-controlled Study. Int J Obstet Anesth. 2012;21(1):24-8. PubMed PMID: 22100822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. AU - Sahoo,T, AU - SenDasgupta,C, AU - Goswami,A, AU - Hazra,A, Y1 - 2011/11/18/ PY - 2009/07/18/received PY - 2011/07/28/revised PY - 2011/08/28/accepted PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2012/5/12/medline SP - 24 EP - 8 JF - International journal of obstetric anesthesia JO - Int J Obstet Anesth VL - 21 IS - 1 N2 - BACKGROUND: Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby. Animal studies suggest that in the presence of decreased blood volume, 5-HT may be an important factor inducing the Bezold Jarisch reflex via 5-HT3 receptors located in intracardiac vagal nerve endings. In this study, we evaluated the effect of ondansetron, as a 5-HT3 receptor antagonist, on the haemodynamic response following subarachnoid block in parturients undergoing elective caesarean section. METHODS: Fifty-two parturients scheduled for elective caesarean section were randomly allocated into two groups. Before induction of spinal anaesthesia Group O (n=26) received intravenous ondansetron 4 mg; Group S (n=26) received normal saline. Blood pressure, heart rate and vasopressor requirements were assessed. RESULTS: Decreases in mean arterial pressure were significantly lower in Group O than Group S from 14 min until 35 min. Patients in Group O required significantly less vasopressor (P=0.009) and had significantly lower incidences of nausea and vomiting (P=0.049). CONCLUSION: Ondansetron 4 mg, given intravenously 5 min before subarachnoid block reduced hypotension and vasopressor use in parturients undergoing elective caesarean section. SN - 1532-3374 UR - https://www.unboundmedicine.com/medline/citation/22100822/Reduction_in_spinal_induced_hypotension_with_ondansetron_in_parturients_undergoing_caesarean_section:_a_double_blind_randomised_placebo_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-289X(11)00091-4 DB - PRIME DP - Unbound Medicine ER -