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Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after the surgery and various phases of the chemotherapy.
Fitoterapia 2012; 83(2):310-7F

Abstract

Since the extract from berries of Aronia melanocarpa presents antioxidative properties in plasma and in blood platelets, not only from healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer before surgery, the aim of our present study was to evaluate the oxidative stress by measuring the level of various biomarkers of this process such as the generation of superoxide anion radicals (O(2)(-·)), the amount of carbonyl groups and 3-nitrotyrosine in proteins or the amount of glutathione in blood platelets isolated from breast cancer patients after the surgery and after various phases of the chemotherapy in the presence of A. melanocarpa extract (Aronox) in vitro. We demonstrated in platelet proteins from patients with invasive breast cancer (after the surgery and after various phases of the chemotherapy) higher level of carbonyl groups than in control healthy group. The level of 3-nitrotyrosine in platelet proteins from patients with invasive breast cancer was also significantly higher than in healthy subject group. We observed an increase of other biomarkers of oxidative stress such as O(2)(-·) and a decrease of GSH in platelets from patients with breast cancer (after the surgery and after various phases of the chemotherapy) compared to the healthy group. In model system in vitro our results showed that the commercial extract from berries of A. melanocarpa due to antioxidant action, significantly reduced the oxidative/nitrative stress in platelets from patients with invasive breast cancer caused by the surgery and various phases of the chemotherapy.

Authors+Show Affiliations

Department of General Biochemistry, University of Lodz, Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22101070

Citation

Kedzierska, Magdalena, et al. "Effects of the Commercial Extract of Aronia On Oxidative Stress in Blood Platelets Isolated From Breast Cancer Patients After the Surgery and Various Phases of the Chemotherapy." Fitoterapia, vol. 83, no. 2, 2012, pp. 310-7.
Kedzierska M, Olas B, Wachowicz B, et al. Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after the surgery and various phases of the chemotherapy. Fitoterapia. 2012;83(2):310-7.
Kedzierska, M., Olas, B., Wachowicz, B., Glowacki, R., Bald, E., Czernek, U., ... Jeziorski, A. (2012). Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after the surgery and various phases of the chemotherapy. Fitoterapia, 83(2), pp. 310-7. doi:10.1016/j.fitote.2011.11.007.
Kedzierska M, et al. Effects of the Commercial Extract of Aronia On Oxidative Stress in Blood Platelets Isolated From Breast Cancer Patients After the Surgery and Various Phases of the Chemotherapy. Fitoterapia. 2012;83(2):310-7. PubMed PMID: 22101070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after the surgery and various phases of the chemotherapy. AU - Kedzierska,Magdalena, AU - Olas,Beata, AU - Wachowicz,Barbara, AU - Glowacki,Rafal, AU - Bald,Edward, AU - Czernek,Urszula, AU - Szydłowska-Pazera,Katarzyna, AU - Potemski,Piotr, AU - Piekarski,Janusz, AU - Jeziorski,Arkadiusz, Y1 - 2011/11/12/ PY - 2011/11/02/received PY - 2011/11/04/accepted PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2013/4/10/medline SP - 310 EP - 7 JF - Fitoterapia JO - Fitoterapia VL - 83 IS - 2 N2 - Since the extract from berries of Aronia melanocarpa presents antioxidative properties in plasma and in blood platelets, not only from healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer before surgery, the aim of our present study was to evaluate the oxidative stress by measuring the level of various biomarkers of this process such as the generation of superoxide anion radicals (O(2)(-·)), the amount of carbonyl groups and 3-nitrotyrosine in proteins or the amount of glutathione in blood platelets isolated from breast cancer patients after the surgery and after various phases of the chemotherapy in the presence of A. melanocarpa extract (Aronox) in vitro. We demonstrated in platelet proteins from patients with invasive breast cancer (after the surgery and after various phases of the chemotherapy) higher level of carbonyl groups than in control healthy group. The level of 3-nitrotyrosine in platelet proteins from patients with invasive breast cancer was also significantly higher than in healthy subject group. We observed an increase of other biomarkers of oxidative stress such as O(2)(-·) and a decrease of GSH in platelets from patients with breast cancer (after the surgery and after various phases of the chemotherapy) compared to the healthy group. In model system in vitro our results showed that the commercial extract from berries of A. melanocarpa due to antioxidant action, significantly reduced the oxidative/nitrative stress in platelets from patients with invasive breast cancer caused by the surgery and various phases of the chemotherapy. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/22101070/Effects_of_the_commercial_extract_of_aronia_on_oxidative_stress_in_blood_platelets_isolated_from_breast_cancer_patients_after_the_surgery_and_various_phases_of_the_chemotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(11)00283-8 DB - PRIME DP - Unbound Medicine ER -