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Seroprevalence of pandemic H1N1 antibody among health care workers in Hong Kong following receipt of monovalent 2009 H1N1 influenza vaccine.

Abstract

BACKGROUND

Healthcare workers in many countries are recommended to receive influenza vaccine to protect themselves as well as patients. A monovalent H1N1 vaccine became available in Hong Kong in December 2009 and around 10% of local healthcare workers had received the vaccine by February 2010.

METHODS

We conducted a cross-sectional study of the prevalence of antibody to pandemic (H1N1) 2009 among HCWs in Hong Kong in February-March 2010 following the first pandemic wave and the pH1N1 vaccination campaign. In this study we focus on the subset of healthcare workers who reported receipt of non-adjuvanted monovalent 2009 H1N1 vaccine (Panenza, Sanofi Pasteur). Sera collected from HCWs were tested for antibody against the pH1N1 virus by hemagglutination inhibition (HI) and viral neutralization (VN) assays.

RESULTS

We enrolled 703 HCWs. Among 104 HCWs who reported receipt of pH1N1 vaccine, 54% (95% confidence interval (CI): 44%-63%) had antibody titer ≥1∶40 by HI and 42% (95% CI: 33%-52%) had antibody titer ≥1∶40 by VN. The proportion of HCWs with antibody titer ≥1∶40 by HI and VN significantly decreased with age, and the proportion with antibody titer ≥1∶40 by VN was marginally significantly lower among HCWs who reported prior receipt of 2007-08 seasonal influenza vaccine (odds ratio: 0.43; 95% CI: 0.19-1.00). After adjustment for age, the effect of prior seasonal vaccine receipt was not statistically significant.

CONCLUSIONS

Our findings suggest that monovalent H1N1 vaccine may have had suboptimal immunogenicity in HCWs in Hong Kong. Larger studies are required to confirm whether influenza vaccine maintains high efficacy and effectiveness in HCWs.

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  • Authors+Show Affiliations

    ,

    Infectious Disease Epidemiology Group, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.

    , , , , , , , ,

    Source

    PloS one 6:11 2011 pg e27169

    MeSH

    Adult
    Antibodies, Viral
    Cross-Sectional Studies
    Female
    Health Personnel
    Hemagglutination Inhibition Tests
    Hong Kong
    Humans
    Influenza A Virus, H1N1 Subtype
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Neutralization Tests
    Occupational Exposure
    Pandemics
    Seroepidemiologic Studies
    Vaccination
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22102878

    Citation

    Zhou, Ying, et al. "Seroprevalence of Pandemic H1N1 Antibody Among Health Care Workers in Hong Kong Following Receipt of Monovalent 2009 H1N1 Influenza Vaccine." PloS One, vol. 6, no. 11, 2011, pp. e27169.
    Zhou Y, Ng DM, Seto WH, et al. Seroprevalence of pandemic H1N1 antibody among health care workers in Hong Kong following receipt of monovalent 2009 H1N1 influenza vaccine. PLoS ONE. 2011;6(11):e27169.
    Zhou, Y., Ng, D. M., Seto, W. H., Ip, D. K., Kwok, H. K., Ma, E. S., ... Cowling, B. J. (2011). Seroprevalence of pandemic H1N1 antibody among health care workers in Hong Kong following receipt of monovalent 2009 H1N1 influenza vaccine. PloS One, 6(11), pp. e27169. doi:10.1371/journal.pone.0027169.
    Zhou Y, et al. Seroprevalence of Pandemic H1N1 Antibody Among Health Care Workers in Hong Kong Following Receipt of Monovalent 2009 H1N1 Influenza Vaccine. PLoS ONE. 2011;6(11):e27169. PubMed PMID: 22102878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Seroprevalence of pandemic H1N1 antibody among health care workers in Hong Kong following receipt of monovalent 2009 H1N1 influenza vaccine. AU - Zhou,Ying, AU - Ng,Diane M W, AU - Seto,Wing-Hong, AU - Ip,Dennis K M, AU - Kwok,Henry K H, AU - Ma,Edward S K, AU - Ng,Sophia, AU - Lau,Lincoln L H, AU - Peiris,J S Malik, AU - Cowling,Benjamin J, Y1 - 2011/11/10/ PY - 2011/05/13/received PY - 2011/10/11/accepted PY - 2011/11/22/entrez PY - 2011/11/22/pubmed PY - 2012/5/9/medline SP - e27169 EP - e27169 JF - PloS one JO - PLoS ONE VL - 6 IS - 11 N2 - BACKGROUND: Healthcare workers in many countries are recommended to receive influenza vaccine to protect themselves as well as patients. A monovalent H1N1 vaccine became available in Hong Kong in December 2009 and around 10% of local healthcare workers had received the vaccine by February 2010. METHODS: We conducted a cross-sectional study of the prevalence of antibody to pandemic (H1N1) 2009 among HCWs in Hong Kong in February-March 2010 following the first pandemic wave and the pH1N1 vaccination campaign. In this study we focus on the subset of healthcare workers who reported receipt of non-adjuvanted monovalent 2009 H1N1 vaccine (Panenza, Sanofi Pasteur). Sera collected from HCWs were tested for antibody against the pH1N1 virus by hemagglutination inhibition (HI) and viral neutralization (VN) assays. RESULTS: We enrolled 703 HCWs. Among 104 HCWs who reported receipt of pH1N1 vaccine, 54% (95% confidence interval (CI): 44%-63%) had antibody titer ≥1∶40 by HI and 42% (95% CI: 33%-52%) had antibody titer ≥1∶40 by VN. The proportion of HCWs with antibody titer ≥1∶40 by HI and VN significantly decreased with age, and the proportion with antibody titer ≥1∶40 by VN was marginally significantly lower among HCWs who reported prior receipt of 2007-08 seasonal influenza vaccine (odds ratio: 0.43; 95% CI: 0.19-1.00). After adjustment for age, the effect of prior seasonal vaccine receipt was not statistically significant. CONCLUSIONS: Our findings suggest that monovalent H1N1 vaccine may have had suboptimal immunogenicity in HCWs in Hong Kong. Larger studies are required to confirm whether influenza vaccine maintains high efficacy and effectiveness in HCWs. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22102878/Seroprevalence_of_pandemic_H1N1_antibody_among_health_care_workers_in_Hong_Kong_following_receipt_of_monovalent_2009_H1N1_influenza_vaccine_ L2 - http://dx.plos.org/10.1371/journal.pone.0027169 DB - PRIME DP - Unbound Medicine ER -