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Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes.
J Diabetes. 2012 Jun; 4(2):164-71.JD

Abstract

BACKGROUND

Moringa oleifera, a widely cultivated species in India, is an exceptionally nutritious vegetable with a variety of potential uses in treating rheumatism, venomous bites, and microbial infections. In the present study, we investigated the antidiabetic and antioxidant effects of methanol extracts of M. oleifera pods (MOMtE) in streptozotocin (STZ)-induced diabetic albino rats.

METHODS

Diabetic rats were treated with 150 or 300 mg/kg MOMtE for 21 days and the antidiabetic effects of the extract were evaluated by measuring changes in biochemical parameters in the serum and pancreatic tissue. Two phytoconstituents, namely quercetin and kaempferol, were isolated from the MOMtE extract and their structures were determined using nuclear magnetic resonance and infrared spectroscopy.

RESULTS

The progression of diabetes was significantly reduced after MOMtE treatment. In treated rats, both doses of MOMtE induced a significant reduction in serum glucose and nitric oxide, with concomitant increases in serum insulin and protein levels. Furthermore, MOMtE treatment increased antioxidant levels in pancreatic tissue, with concomitant decreases in levels of thiobarbituric acid-reactive substances. Histologic examination of the pancreas from diabetic rats showed degenerative changes in β-cells; MOMtE treatment significantly reversed the histoarchitectural damage to the islets cells.

CONCLUSION

In conclusion, M. oleifera exerts protective effects against STZ-induced diabetes. The MOMtE exhibited significant antidiabetic and antioxidant activity and active constituents may be isolated from the extract for evaluation in future clinical studies.

Authors+Show Affiliations

Reproductive Physiology Section, Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India. gupta_rs@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22103446

Citation

Gupta, Rajnish, et al. "Evaluation of Antidiabetic and Antioxidant Activity of Moringa Oleifera in Experimental Diabetes." Journal of Diabetes, vol. 4, no. 2, 2012, pp. 164-71.
Gupta R, Mathur M, Bajaj VK, et al. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J Diabetes. 2012;4(2):164-71.
Gupta, R., Mathur, M., Bajaj, V. K., Katariya, P., Yadav, S., Kamal, R., & Gupta, R. S. (2012). Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. Journal of Diabetes, 4(2), 164-71. https://doi.org/10.1111/j.1753-0407.2011.00173.x
Gupta R, et al. Evaluation of Antidiabetic and Antioxidant Activity of Moringa Oleifera in Experimental Diabetes. J Diabetes. 2012;4(2):164-71. PubMed PMID: 22103446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. AU - Gupta,Rajnish, AU - Mathur,Manas, AU - Bajaj,Vijay K, AU - Katariya,Pawan, AU - Yadav,Sunita, AU - Kamal,Raka, AU - Gupta,Radhey S, PY - 2011/11/23/entrez PY - 2011/11/23/pubmed PY - 2012/9/21/medline SP - 164 EP - 71 JF - Journal of diabetes JO - J Diabetes VL - 4 IS - 2 N2 - BACKGROUND: Moringa oleifera, a widely cultivated species in India, is an exceptionally nutritious vegetable with a variety of potential uses in treating rheumatism, venomous bites, and microbial infections. In the present study, we investigated the antidiabetic and antioxidant effects of methanol extracts of M. oleifera pods (MOMtE) in streptozotocin (STZ)-induced diabetic albino rats. METHODS: Diabetic rats were treated with 150 or 300 mg/kg MOMtE for 21 days and the antidiabetic effects of the extract were evaluated by measuring changes in biochemical parameters in the serum and pancreatic tissue. Two phytoconstituents, namely quercetin and kaempferol, were isolated from the MOMtE extract and their structures were determined using nuclear magnetic resonance and infrared spectroscopy. RESULTS: The progression of diabetes was significantly reduced after MOMtE treatment. In treated rats, both doses of MOMtE induced a significant reduction in serum glucose and nitric oxide, with concomitant increases in serum insulin and protein levels. Furthermore, MOMtE treatment increased antioxidant levels in pancreatic tissue, with concomitant decreases in levels of thiobarbituric acid-reactive substances. Histologic examination of the pancreas from diabetic rats showed degenerative changes in β-cells; MOMtE treatment significantly reversed the histoarchitectural damage to the islets cells. CONCLUSION: In conclusion, M. oleifera exerts protective effects against STZ-induced diabetes. The MOMtE exhibited significant antidiabetic and antioxidant activity and active constituents may be isolated from the extract for evaluation in future clinical studies. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/22103446/Evaluation_of_antidiabetic_and_antioxidant_activity_of_Moringa_oleifera_in_experimental_diabetes_ L2 - https://doi.org/10.1111/j.1753-0407.2011.00173.x DB - PRIME DP - Unbound Medicine ER -