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Surgical treatment of macroglossia in patients with Beckwith-Wiedemann syndrome: a 20-year experience and review of the literature.
Int J Oral Maxillofac Surg. 2012 Mar; 41(3):300-8.IJ

Abstract

Macroglossia is observed in the majority of paediatric patients diagnosed with Beckwith-Wiedemann syndrome and surgical treatment may be indicated. A 20-year retrospective study was performed to evaluate all patients with Beckwith-Wiedemann syndrome who underwent tongue reduction surgery at the authors' institution. A literature review was performed. Surgical treatment was indicated and carried out in 23 patients with a yearly average varying from 0 to 3 subjects. The mean follow-up time was 7 years. Primary indications for surgical treatment of macroglossia included significant tongue protrusion in 30% (n=7), and a combination of clinical problems in 70% (n=16). In all cases, the procedure was performed by the same surgeon using an anterior, V-shaped, wedge resection technique. Two patients had direct postoperative complications. No recurrence of macroglossia was observed in this study. Reported clinical outcome during follow-up demonstrated a satisfactory resting tongue position in all patients. Review of the literature demonstrated variability in surgical indications and techniques, and postoperative outcome. The results of this study indicate that the anterior wedge resection is a simple, effective and safe technique in the surgical treatment of paediatric patients, diagnosed with Beckwith-Wiedemann syndrome, suffering from macroglossia.

Authors+Show Affiliations

Department of Plastic and Reconstructive Surgery, Academic Medical Center, Amsterdam, The Netherlands. d.j.kadouch@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22104000

Citation

Kadouch, D J M., et al. "Surgical Treatment of Macroglossia in Patients With Beckwith-Wiedemann Syndrome: a 20-year Experience and Review of the Literature." International Journal of Oral and Maxillofacial Surgery, vol. 41, no. 3, 2012, pp. 300-8.
Kadouch DJ, Maas SM, Dubois L, et al. Surgical treatment of macroglossia in patients with Beckwith-Wiedemann syndrome: a 20-year experience and review of the literature. Int J Oral Maxillofac Surg. 2012;41(3):300-8.
Kadouch, D. J., Maas, S. M., Dubois, L., & van der Horst, C. M. (2012). Surgical treatment of macroglossia in patients with Beckwith-Wiedemann syndrome: a 20-year experience and review of the literature. International Journal of Oral and Maxillofacial Surgery, 41(3), 300-8. https://doi.org/10.1016/j.ijom.2011.10.021
Kadouch DJ, et al. Surgical Treatment of Macroglossia in Patients With Beckwith-Wiedemann Syndrome: a 20-year Experience and Review of the Literature. Int J Oral Maxillofac Surg. 2012;41(3):300-8. PubMed PMID: 22104000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical treatment of macroglossia in patients with Beckwith-Wiedemann syndrome: a 20-year experience and review of the literature. AU - Kadouch,D J M, AU - Maas,S M, AU - Dubois,L, AU - van der Horst,C M A M, Y1 - 2011/11/21/ PY - 2011/06/16/received PY - 2011/08/18/revised PY - 2011/10/20/accepted PY - 2011/11/23/entrez PY - 2011/11/23/pubmed PY - 2012/8/14/medline SP - 300 EP - 8 JF - International journal of oral and maxillofacial surgery JO - Int J Oral Maxillofac Surg VL - 41 IS - 3 N2 - Macroglossia is observed in the majority of paediatric patients diagnosed with Beckwith-Wiedemann syndrome and surgical treatment may be indicated. A 20-year retrospective study was performed to evaluate all patients with Beckwith-Wiedemann syndrome who underwent tongue reduction surgery at the authors' institution. A literature review was performed. Surgical treatment was indicated and carried out in 23 patients with a yearly average varying from 0 to 3 subjects. The mean follow-up time was 7 years. Primary indications for surgical treatment of macroglossia included significant tongue protrusion in 30% (n=7), and a combination of clinical problems in 70% (n=16). In all cases, the procedure was performed by the same surgeon using an anterior, V-shaped, wedge resection technique. Two patients had direct postoperative complications. No recurrence of macroglossia was observed in this study. Reported clinical outcome during follow-up demonstrated a satisfactory resting tongue position in all patients. Review of the literature demonstrated variability in surgical indications and techniques, and postoperative outcome. The results of this study indicate that the anterior wedge resection is a simple, effective and safe technique in the surgical treatment of paediatric patients, diagnosed with Beckwith-Wiedemann syndrome, suffering from macroglossia. SN - 1399-0020 UR - https://www.unboundmedicine.com/medline/citation/22104000/Surgical_treatment_of_macroglossia_in_patients_with_Beckwith_Wiedemann_syndrome:_a_20_year_experience_and_review_of_the_literature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0901-5027(11)01476-7 DB - PRIME DP - Unbound Medicine ER -