Tags

Type your tag names separated by a space and hit enter

Local recurrence as immunoglobulin G4 (IgG4)-related disease 10 years after radiotherapy to ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.
J Clin Exp Hematop. 2011; 51(2):125-33.JC

Abstract

In 2000, a 48-year-old woman developed a left orbital mass with lacrimal gland involvement and then, in 2003, a right orbital mass with lacrimal gland involvement, both of which were diagnosed as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). She underwent 30 Gy external beam radiation to bilateral orbital lesions. The lymphoma cells in both lesions did not share the same clonality, as shown by amplification by polymerase chain reaction of the immunoglobulin heavy chain gene. Immunoglobulin light chain analysis by immunohistochemistry and messenger RNA in situ hybridization showed λ chain monotype in the left orbital lesion but κ chain monotype in the right orbital lesion. She developed recurrent left orbital mass with high uptake on fluorodeoxyglucose positron emission tomography fused with computed tomography in 2010, and excisional biopsy disclosed the formation of follicles and infiltration with immunoglobulin G4 (IgG4)-positive plasma cells mainly in interfollicular areas. The immunoglobulin light chain analysis showed the λ chain and κ chain bitype. With the immunohistopathological diagnosis of IgG4-related disease, the serum IgG4 level was found to show elevation at 376 mg/dL, and the patient chose observation. This is the first reported case of development of IgG4-related disease after bilataral orbital MALT lymphoma with external beam radiotherapy.

Authors+Show Affiliations

Department of Ophthalmology, Okayama University Medical School, and Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama City, Japan. matsuot@cc.okayama-u.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22104312

Citation

Matsuo, Toshihiko, et al. "Local Recurrence as Immunoglobulin G4 (IgG4)-related Disease 10 Years After Radiotherapy to Ocular Adnexal Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue." Journal of Clinical and Experimental Hematopathology : JCEH, vol. 51, no. 2, 2011, pp. 125-33.
Matsuo T, Ichimura K, Yoshino T. Local recurrence as immunoglobulin G4 (IgG4)-related disease 10 years after radiotherapy to ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. J Clin Exp Hematop. 2011;51(2):125-33.
Matsuo, T., Ichimura, K., & Yoshino, T. (2011). Local recurrence as immunoglobulin G4 (IgG4)-related disease 10 years after radiotherapy to ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Journal of Clinical and Experimental Hematopathology : JCEH, 51(2), 125-33.
Matsuo T, Ichimura K, Yoshino T. Local Recurrence as Immunoglobulin G4 (IgG4)-related Disease 10 Years After Radiotherapy to Ocular Adnexal Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue. J Clin Exp Hematop. 2011;51(2):125-33. PubMed PMID: 22104312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local recurrence as immunoglobulin G4 (IgG4)-related disease 10 years after radiotherapy to ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. AU - Matsuo,Toshihiko, AU - Ichimura,Kouichi, AU - Yoshino,Tadashi, PY - 2011/11/23/entrez PY - 2011/11/23/pubmed PY - 2012/6/5/medline SP - 125 EP - 33 JF - Journal of clinical and experimental hematopathology : JCEH JO - J Clin Exp Hematop VL - 51 IS - 2 N2 - In 2000, a 48-year-old woman developed a left orbital mass with lacrimal gland involvement and then, in 2003, a right orbital mass with lacrimal gland involvement, both of which were diagnosed as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). She underwent 30 Gy external beam radiation to bilateral orbital lesions. The lymphoma cells in both lesions did not share the same clonality, as shown by amplification by polymerase chain reaction of the immunoglobulin heavy chain gene. Immunoglobulin light chain analysis by immunohistochemistry and messenger RNA in situ hybridization showed λ chain monotype in the left orbital lesion but κ chain monotype in the right orbital lesion. She developed recurrent left orbital mass with high uptake on fluorodeoxyglucose positron emission tomography fused with computed tomography in 2010, and excisional biopsy disclosed the formation of follicles and infiltration with immunoglobulin G4 (IgG4)-positive plasma cells mainly in interfollicular areas. The immunoglobulin light chain analysis showed the λ chain and κ chain bitype. With the immunohistopathological diagnosis of IgG4-related disease, the serum IgG4 level was found to show elevation at 376 mg/dL, and the patient chose observation. This is the first reported case of development of IgG4-related disease after bilataral orbital MALT lymphoma with external beam radiotherapy. SN - 1880-9952 UR - https://www.unboundmedicine.com/medline/citation/22104312/Local_recurrence_as_immunoglobulin_G4__IgG4__related_disease_10_years_after_radiotherapy_to_ocular_adnexal_extranodal_marginal_zone_B_cell_lymphoma_of_mucosa_associated_lymphoid_tissue_ L2 - http://japanlinkcenter.org/JST.JSTAGE/jslrt/51.125?from=PubMed DB - PRIME DP - Unbound Medicine ER -